2,4,6-Trimethoxy chalcone derivatives: an integrated study for redesigning novel chemical entities as anticancer agents through QSAR, molecular docking, ADMET prediction, and computational simulation [0.03%]
2,4,6-三甲氧基查耳酮衍生物：通过QSAR，分子对接，ADMET预测和计算机模拟的集成研究以重新设计新型抗癌剂化学实体
Trupti S Chitre,Aayush M Mandot,Ramali D Bhagwat et al.
Trupti S Chitre et al.
QSAR, an efficient and successful approach for optimizing lead compounds in drug design, was employed to study a reported series of compounds derived from 2,4,6-trimethoxy chalcone derivatives. The ability of these compounds to inhibit CDK1...
Molecular interaction studies of P3CL on bovine serum albumin through biophysical approach [0.03%]
通过生物物理方法研究P3CL与牛血清白蛋白的分子相互作用
Malasree Lakshmanan,Sangilimuthu Alagar Yadav,Manjunath Meti et al.
Malasree Lakshmanan et al.
In the fields of pharmacology and life sciences, it is essential to study how prescribed drugs interact with carrier proteins in human serum albumin. The current study has evaluated the binding properties of rhodanine derivative; (z)-2-(4-(...
Computational study of the piperidine and FtsZ interaction in Salmonella Typhi: implications for disrupting cell division machinery [0.03%]
鼠李碱和FtsZ在伤寒沙门氏菌中的相互作用的计算研究:对破坏细胞分裂装置的意义
Hithesh Kumar,Anand Manoharan,Anand Anbarasu et al.
Hithesh Kumar et al.
FtsZ, a bacterial cell division protein, is essential for assembling the contractile Z-ring crucial in bacterial cytokinesis. Consequently, inhibiting FtsZ could impede proto-filaments, disrupting FtsZ and other associated proteins vital fo...
Insights into the crystal structure investigation and virtual screening approach of quinoxaline derivatives as potent against c-Jun N-terminal kinases 1 [0.03%]
喹唑啉衍生物的晶体结构研究和虚拟筛选方法的见解，可有效针对c-Jun氨基末端激酶1
Shaaban K Mohamed,Subramani Karthikeyan,Omran A Omran et al.
Shaaban K Mohamed et al.
Quinoxaline derivatives are an important class of heterocyclic compounds in which N replaces one or more carbon atoms of the naphthalene ring and exhibit a wide spectrum of biological activities and therapeutic applications. As a result, we...
Mutational analysis of consanguineous families and their targeted therapy against dwarfism [0.03%]
consanguineous家族的突变分析及矮小症的针对性治疗
Feroz Khan,Sarmir Khan,Nehal Rana et al.
Feroz Khan et al.
Dwarfism is a medical term used to describe individuals with a height-vertex measurement that falls below two standard deviations (-2SD) or the third percentile for their gender and age. Normal development of growth is a complicated dynamic...
Insight into carbohydrate metabolism, protein quantification and mineral regulation in wheat (Triticum aestivum L.) by the action of green synthesized silver nanoparticles (AgNPs) against heat stress [0.03%]
银纳米粒子(AgNPs)对小麦(Triticum aestivum L.)抗热应力的碳水化合物代谢、蛋白质定量和矿物调节的机理分析
注：此翻译虽然忠实于原文，但略显冗长。在实际应用中，可以考虑简化为“绿色合成银纳米粒子对抗热应激的小麦代谢效应研究”，以更好地符合中文标题的习惯。
Muhammad Iqbal,Naveed Iqbal Raja,Zia-Ur-Rehman Mashwani et al.
Muhammad Iqbal et al.
In the present investigation, the role of GS-AgNPs treatment in wheat plants was carried out in reducing heat stress with the aim of facilitating scientists on this topic. The effect of GS-AgNPs against heat stress has rarely been deliberat...
In-silico and in-vitro evaluation of antifungal bioactive compounds from Streptomyces sp. strain 130 against Aspergillus flavus [0.03%]
链霉菌130株抗曲霉属真菌的抗真菌生物活性化合物的体外和计算机模拟评估
Munendra Kumar,Parveen,Nafis Raj et al.
Munendra Kumar et al.
Streptomyces spp. are considered excellent reservoirs of natural bioactive compounds. The study evaluated the bioactive potential of secondary metabolites from Streptomyces sp. strain 130 through PKS-I and NRPS gene-clusters screening. GC-M...
The potential of some functional group compounds substituted 8-Manzamine A as RSK1 inhibitors: molecular docking and molecular dynamics simulations [0.03%]
某些含功能团的8-曼扎胺A衍生物作为RSK1抑制剂的潜力：分子对接和分子动力学模拟研究
Ala&#x; Omar Hasan Zayed,Mousa Altarabeen,Ehab AlShamaileh et al.
Ala&#x; Omar Hasan Zayed et al.
Cancer, an incurable global disease, demands urgent anti-cancer drug development. Marine alkaloids like Manzamine and its derivatives show promise as RSK inhibitors against cancer cell invasion. Replacing the hydrogen at the 8-position of M...
Structure-based evaluation of the envelope domain III-nonstructural protein 1 (EDIII-NS1) fusion as a dengue virus vaccine candidate [0.03%]
基于结构的包膜蛋白III-非结构蛋白1(EDIII-NS1)融合体作为登革热病毒疫苗候选者的评估
Mohammad Shoushtari,Elham Rismani,Mostafa Salehi-Vaziri et al.
Mohammad Shoushtari et al.
The lack of effective medicines or vaccines, combined with climate change and other environmental factors, annually subjects a significant proportion of the world's inhabitants to the risk of dengue virus (DENV) infection. These conditions ...
Mechanistic influence of discreet conformation of human telomerase linker region [0.03%]
人类端粒酶连接区离散构象的机制影响
Varun P Talati,Vamika Karn,Nikhil Gadewal et al.
Varun P Talati et al.
Approximately 90% of malignancies have been shown to have human telomerase activity, establishing it as a viable therapeutic target. The crystal structure of telomerase was determined recently. However, the tertiary structure of the non-con...