Behenic Acid as a multi-target inhibiting antibacterial phytochemical against Vibrio parahaemolyticus and Aeromonas hydrophila for effective management of aquaculture infections: an in-silico, in-vitro & in-vivo experimentation [0.03%]
月桂二酸作为多目标抑制抗菌植化物对抗副溶血弧菌和嗜水气单胞菌以有效管理水产养殖感染：一种计算机模拟、体外和体内实验
Lokesh Ravi,Ajith Kumar K,Shree Kumari G R et al.
Lokesh Ravi et al.
Multi-Target Inhibitors are the upcoming frontrunners of the antibiotic world as they provide significant advantage over drug resistance development. Antibacterial drug discovery research, requires more robust and innovative approaches such...
Benzoic acid, 4-hydroxy-, methyl ester from Smilax zeylanica Linn emerges as a potent inhibitor of CD27/CD70 signaling pathway [0.03%]
来自Smilax zeylanica Linn的4-羟基苯甲酸甲酯作为CD27 / CD70信号通路的强大抑制剂出现
K Deepa Deva,B Vanitha Bose,Cardiliya A P
K Deepa Deva
Smilax zeylanica Linn is explored as a natural solution to inhibit the CD27/CD70 interaction crucial in T and B cell responses. This plant-based approach offers a cost-effective and promising drug candidate for overcoming challenges associa...
Design, synthesis, in-vitro biological profiling and molecular docking of some novel oxazolones and imidazolones exhibiting good inhibitory potential against acetylcholine esterase [0.03%]
一些新型的oxazolones和imidazolones的设计，合成，体外生物检测和分子对接，这些物质对乙酰胆碱酯酶有良好的抑制作用
Iqra Saleem Naz Babari,Muhammad Islam,Hamid Saeed et al.
Iqra Saleem Naz Babari et al.
Heterocyclic compounds with oxazole and imidazole rings in their structure have disclosed momentous biological aptitudes. Taking into account their superlative attributes, the present study was designed to introduce a new synthetic scheme t...
Structural, functional, molecular docking analysis of a hypothetical protein from Talaromyces marneffei and its molecular dynamic simulation: an in-silico approach [0.03%]
马内菲青霉假定蛋白的结构、功能及分子对接分析：一种基于计算机模拟的方法
Md Masudur Rahman Munna,Md Ariful Islam,Saima Sajnin Shanta et al.
Md Masudur Rahman Munna et al.
Telaromyces marneffei (formerly Penicillium marneffei) is an endemic pathogenic fungus in Southern China and Southeast Asia. It can cause disease in patients with travel-related exposure to this organism and high morbidity and mortality in ...
Probing the interaction behavior of Nano-Resveratrol with α-lactalbumin in the presence of β-lactoglobulin and β-casein: spectroscopy and molecular simulation studies [0.03%]
β-乳球蛋白和β-酪蛋白存在条件下，纳米白藜芦醇与α-乳清蛋白相互作用行为的光谱及分子模拟研究
Zahra Ghadamgahi,Alireza Motavalizadehkakhky,Jamshid Mehrzad et al.
Zahra Ghadamgahi et al.
The main purpose of this research was to evaluate the role of α-lactalbumin (α-LA), β-lactoglobulin (β-LG), and β-Caseins (β-CN) in the binding interaction between Nano Resveratrol (Nano Res), as binary and ternary systems. This inves...
Chinese herb couple against diabetes: integrating network pharmacology and mechanism study [0.03%]
抗糖尿病的中药药对：网络药理学与机制研究的结合
Jing Li,Nini Jia,Mengyao Cui et al.
Jing Li et al.
Cassia twig is a dry twig of Cinnamomum cassia Presl, a Lauraceae plant. Astragalus L is one of the largest genuses of flowering plants in the Leguminosae family. Roots of A. membranaceus Bge. var. mongholicus (Bge.) Hsiao, A. membranaceus ...
EIF4A3 targeted therapeutic intervention in glioblastoma multiforme using phytochemicals from Indian medicinal plants - an integration of phytotherapy into precision onco-medicine [0.03%]
来自印度药用植物的药用化学成分对胶质母细胞瘤中的EIF4A3靶向治疗干预-将植物疗法与精准肿瘤医学相结合
Sohini Kulavi,Debajit Dhar,Izaz Monir Kamal et al.
Sohini Kulavi et al.
Glioblastoma Multiforme (GBM), an aggressive brain tumor (grade-IV astrocytoma), poses treatment challenges. Poor prognosis results from the rapid growth, highlighting the role of EIF4A3 in regulating non-coding RNAs. EIF4A3 promotes the ex...
EDLNet: ensemble deep learning network model for automatic brain tumor classification and segmentation [0.03%]
EDLNet：用于自动脑肿瘤分类和分割的集成深度学习网络模型
Surendra Reddy Vinta,Phaneendra Varma Chintalapati,Gurujukota Ramesh Babu et al.
Surendra Reddy Vinta et al.
The brain's abnormal and uncontrollable cell partitioning is a severe cancer disease. The tissues around the brain or the skull induce this tumor to develop spontaneously. For the treatment of a brain tumor, surgical techniques are typicall...
Discovery of anticancer compound possessing potential to bind γ-secretase catalytic subunit and inhibit notch promoter activity [0.03%]
具有结合γ-分泌酶催化亚基和抑制Notch启动子活性潜力的抗癌化合物的发现
Atul Kumar Singh,Kumari Sunita Prajapati,Shashank Kumar
Atul Kumar Singh
Gamma secretase (GS) is an important therapeutic target in anticancer drug discovery. Increased GS activity activates notch signaling pathway which is associated with cancer stemness and drug resistance in cancer cells. A total of 69,075 na...
Allosteric mechanism of MntR transcription factor from alkalophilic bacterium Halalkalibacterium halodurans [0.03%]
嗜碱菌Halalkalibacterium halodurans的MntR转录因子的别构机制
Ana Marija Knez,Martina Manenica,Zoe Jelić Matošević et al.
Ana Marija Knez et al.
Bacterium Halalkalibacterium halodurans is an industrially important alkalophilic bacteria. It is recognized as a producer of enzymes such as β-galactosidase, xylanase, amylase and protease which are able to function at higher pH values an...