MMV method: a new approach to compare protein sequences under binary representation [0.03%]
二进制表示下比较蛋白质序列的新方法：MMV方法
Jayanta Pal,Soumen Ghosh,Bansibadan Maji et al.
Jayanta Pal et al.
In the present work, a new form of descriptor using minimal moment vector (MMV) is introduced to compare protein sequences in the frequency domain under their component wise binary representations. From every sequence, 20 different binary c...
Discovery of novel inhibitor via molecular dynamics simulations against D-alanyl-D-alanine carboxypeptidase of Enterobacter cloacae [0.03%]
分子动力学模拟发现新型D- Ala-D- Ala羧肽酶抑制剂
Faisal Ahmad,Saba Ismail,Syed Sikander Azam
Faisal Ahmad
Antibiotics resistance by bacterial pathogens is a major concern to public health worldwide resulting in high health care costs and rising mortality. Subtractive proteomics prioritized D-alanyl-D-alanine carboxypeptidas (DacB) enzyme from E...
Revealing the binding mechanism of BACE1 inhibitors through molecular dynamics simulations [0.03%]
分子动力学模拟揭示BACE1抑制剂的作用机制
Yanjun Zhang,Dongqiang Miao,Senchen Liu et al.
Yanjun Zhang et al.
Alzheimer's disease is a debilitating neurodegenerative disorder, and the Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) is a key therapeutic target in its treatment. This study employs molecular dynamics simulations and bind...
Unlocking therapeutic potential: computational insights into TREM2 protein targeting with FDA-approved drugs for neurodegeneration [0.03%]
解锁治疗潜力：计算洞察TREM2蛋白通过FDA批准药物针对神经退行性疾病的可能性
Mohammed Alrouji,Sabina Yasmin,Fahad A Alhumaydhi et al.
Mohammed Alrouji et al.
Neurodegenerative diseases such as Alzheimer's disease (AD) pose a significant global health challenge that requires the exploration of innovative therapeutic strategies. Triggering receptor expressed on myeloid cells-2 (TREM2) is one of th...
Srijan Banerjee,Antara Sengupta,Shankar Kumar Ghosh et al.
Srijan Banerjee et al.
Breast cancer is considered to be happened due to genetic aberration. Out of several genes expressed, it is found that cadherin 1, type 1 (CDH1) is responsible in several ways to control the metabolic order in human. Deregulation of the fun...
A novel deep learning model for diabetic retinopathy detection in retinal fundus images using pre-trained CNN and HWBLSTM [0.03%]
使用预训练CNN和HWBLSTM进行眼底图像糖尿病视网膜病变检测的新深度学习模型
S V Hemanth,Saravanan Alagarsamy,T Dhiliphan Rajkumar
S V Hemanth
Diabetic retinopathy (DR) is a global visual indicator of diabetes that leads to blindness and loss of vision. Manual testing presents a more difficult task when attempting to detect DR due to the complexity and variances of DR. Early detec...
Novel cyanochalcones as potential anticancer agents: apoptosis, cell cycle arrest, DNA binding, and molecular docking studies [0.03%]
新型的氰基查尔酮作为潜在抗癌剂：细胞凋亡，细胞周期阻滞，DNA结合和分子对接研究
Mohamed A Ragheb,Hanan E Abdelrashid,Emad M Elzayat et al.
Mohamed A Ragheb et al.
In the light of anticancer drug discovery and development, a new series of cyanochalcones incorporating indole moiety (5a-g) were efficiently synthesized and characterized by different spectral analysis. MTT assay was used to evaluate the a...
Discovery of small molecules from natural compound databases as potent retinoid X alpha receptor agonists to treat Alzheimer's disease [0.03%]
从天然化合物数据库中发现作为强力视黄醇X受体激动剂治疗阿尔茨海默症的小分子化合物
Alireza Rahimpour,Behzad Shahbazi,Ladan Mafakher
Alireza Rahimpour
Alzheimer's is characterized as a progressive neurodegenerative disease due to beta-amyloid accumulation in the brain. Some previous studies reported that RXR agonists could be effective in the treatment of Alzheimer's disease. There are cu...
Inhibition of NS2B-NS3 protease from all four serotypes of dengue virus by punicalagin, punicalin and ellagic acid identified from Punica granatum [0.03%]
石榴中提取的punicalagin、punicalin和ellagic酸对四型登革热病毒NS2B-NS3蛋白酶的抑制作用
Fouzia Ismat,Anam Tariq,Aqsa Shaheen et al.
Fouzia Ismat et al.
Despite a major threat to the public health in tropical and subtropical regions, dengue virus (DENV) infections are untreatable. Therefore, efforts are needed to investigate cost-effective therapeutic agents that could cure DENV infections ...
Virtual screening of natural products targeting ubiquitin-specific protease 7 [0.03%]
针对泛素特异性蛋白酶7靶点的天然药物虚拟筛选研究
Hongju Li,Yujie Sun,Hua Yin et al.
Hongju Li et al.
Ubiquitin-specific protease 7 (USP7) is a promising prognostic and druggable target for cancer therapy. Inhibition of USP7 can activate the MDM2-P53 signaling pathway, thereby promoting cancer cell apoptosis. This study based on watvina mol...