Multi-spectroscopic and in silico investigation of gambogic acid-calf thymus DNA interactions [0.03%]
多光谱和计算机模拟探究 gambogic酸-小牛胸腺DNA 相互作用
Boddapati Kalyani Bhardwaj,Arsha James,Jiya Tomy et al.
Boddapati Kalyani Bhardwaj et al.
Gambogic acid (GA), a xanthanoid compound, is derived from Garcinia Hanbury gamboge resin. Studying GA's DNA binding and targeting processes is crucial to understanding its tumor-targeting potentiality. This study used spectroscopic and in ...
Biochemical and computational inhibition of α-glucosidase by novel metronidazole-linked 1 H-1,2,3-triazole and carboxylate moieties: kinetics and dynamic investigations [0.03%]
新型甲硝唑接头的1H-1,2,3-三氮唑和羧酸基序对α-葡萄糖苷酶的生化及计算抑制作用：动力学与动态研究
Saeed Ullah,Sobia Ahsan Halim,Muhammad Waqas et al.
Saeed Ullah et al.
In the current study, metronidazole derivatives containing 1H-1,2,3-triazole and carboxylate moieties were evaluated in vitro and by computational methods for their anti-diabetic potential to insight into their medicinal use for the managem...
Nano-gel formulation of polyphenolic fraction of tobacco stem for wound healing and its inhibitory efficacies against the receptors of chronic wound development [0.03%]
用于伤口愈合的烟草茎多酚纳米凝胶制剂及其对慢性伤口受体发育的抑制功效
Yash Sharma,Rohit Bhardwaj,Amritpal Kaur et al.
Yash Sharma et al.
Current investigation deals with the gel formulation of purified polyphenol loaded nanoparticles for enhanced wound healing. Polyphenols purified using column chromatography an were characterized using HPLC in fractions. Silver nanoparticle...
Computational and in vitro screening validates the repositioning potential of Coxibs as anti-fibrotic agents [0.03%]
计算和体外筛选验证了Coxibs作为抗纤维化药物的再定位潜力
Shraddha Karande,Biswajit Das,Sushree Subhadra Acharya et al.
Shraddha Karande et al.
Idiopathic pulmonary fibrosis (IPF) is a life-threatening disease with a survival rate of
Cracking a cancer code DNA methylation in epigenetic modification: an in-silico approach on efficacy assessment of Sri Lanka-oriented nutraceuticals [0.03%]
破解癌症代码：表观遗传修饰中的DNA甲基化：对以斯里兰卡为导向的营养保健品疗效评估的计算机模拟方法
Dushanan R,Weerasinghe S,Dissanayake D P et al.
Dushanan R et al.
DNA methyltransferase (DNMTs) are essential epigenetic modifiers that play a critical role in gene regulation. These enzymes add a methyl group to cytosine's 5'-carbon, specifically within CpG dinucleotides, using S-adenosyl-L-methionine. A...
Discovery of novel bromodomain-containing protein 4 (BRD4-BD1) inhibitors combined with 3d-QSAR, molecular docking and molecular dynamics in silico [0.03%]
基于三维定量结构活性关系、分子对接及分子动力学的新型溴域蛋白4（BRD4-BD1）抑制剂的发现
Rong Liu,Xiaodie Chen,Jiali Li et al.
Rong Liu et al.
Bromine-containing domain protein 4 (BRD4) plays a crucial role in regulating transcription and genome stability. Selective inhibitors of BRD4-BD1 can specifically target specific bromine domains to affect cell proliferation, apoptosis, and...
Toxoplasma gondii aspartic protease 5: structural basis of substrate binding and inhibition mechanism [0.03%]
刚地弓形虫天冬氨酸蛋白酶5：底物结合及抑制机制的结构基础
Satadru Chakraborty,Anuradha Deshmukh,Pooja Kesari et al.
Satadru Chakraborty et al.
Toxoplasma gondii, a worldwide prevalent parasite is responsible for causing toxoplasmosis in almost all warm-blooded animals, including humans. Golgi-resident T. gondii aspartic protease 5 (TgASP5) plays an essential role in the maturation...
C-30 analogues of betulinic acid as potent cytotoxic agents: design, synthesis, biological evaluation and in-silico studies [0.03%]
齐墩果酸C-30类似物作为潜在的细胞毒性药物：设计、合成、生物评价和计算机模拟研究
Santosh K Rath,Rakesh K Nagar,Sanjib Das et al.
Santosh K Rath et al.
In an endeavour to improve the anti-cancer activity of betulinic acid (BA), a series of C-30 derivatives were envisaged and synthesized with a novel synthetic approach. All the derivatives were evaluated for cytotoxic activity by MTT assay ...
Understanding the basis of thermostability for enzyme "Nanoluc" towards designing industry-competent engineered variants [0.03%]
理解酶"Nanoluc"的热稳定性基础以设计具有工业竞争力的工程变体
Adwaita S R Nair,Arup Samanta,Saugata Hazra
Adwaita S R Nair
As a leading contender in the study of luminescence, nanoluciferase has recently attracted attention and proven effective in a wide variety of research areas. Although numerous attempts have been made to improve activity, there has yet to b...
Natural compounds inhibit Monkeypox virus methyltransferase VP39 in silico studies [0.03%]
天然化合物抑制猴痘病毒甲基转移酶VP39的计算机模拟研究
Quynh Mai Thai,Huong T T Phung,Ngoc Quynh Anh Pham et al.
Quynh Mai Thai et al.
VP39, an essential 2'-O-RNA methyltransferase enzyme discovered in Monkeypox virus (MPXV), plays a vital role in viral RNA replication and transcription. Inhibition of the enzyme may prevent viral replication. In this context, using a combi...