Guideline directed medical therapy induced nephrotoxicity in HFrEF patients; an insight to its mechanism [0.03%]
指南导向的药物治疗在HFrEF患者中引起的肾毒性；对其机制的洞察
Anu Philip,Prarambh S R Dwivedi,C S Shastry et al.
Anu Philip et al.
Guideline Directed Medical Therapy (GDMT) has been the standard pharmacotherapy for the treatment of Heart Failure patients with reduced Ejection Fraction (HFrEF) recommended by the European Society of Cardiology (ESC). However, patients on...
Potential bioactive compound and hub gene identification of endometrial carcinoma using systems biology [0.03%]
内膜癌潜在生物活性化合物和枢纽基因的系统生物学鉴定
Shanmugapriya Rishikesan,Parthiban Brindhadevi,Rajakumari K et al.
Shanmugapriya Rishikesan et al.
Endometrial carcinoma is a frequent cancer of the female genital tract. Endometrial carcinoma accounts for 97% of all uterine malignancies and 3 % of sarcomas that develop from the endometrium's glands. Endometrial cancer is frequently foun...
Sakuranetin ameliorates streptozotocin-induced diabetes in rodents by inhibiting caspase-3 activity, modulating hematological parameters, and suppressing inflammatory cytokines: a molecular docking and dynamics study [0.03%]
樱草素通过抑制半胱天冬酶-3活性，调节血液参数和抑制炎症细胞因子来改善由链脲佐菌素引起的啮齿动物糖尿病：分子对接及动力学研究
Hassan H Almasoudi,Mohammed H Nahari,Abdulkarim S Binshaya et al.
Hassan H Almasoudi et al.
Diabetes affects people of all ages, regardless of gender and background. To date, there is no evidence for the effect of sakuranetin against the streptozotocin (STZ)-induced diabetes paradigm. The research was directed to evaluate the anti...
A network pharmacological approach for the identification of potential therapeutic targets of Brahmi Nei - a complex traditional Siddha formulation [0.03%]
Brahmi Nei-复杂传统锡德哈配方潜在治疗靶标的网络药理学研究方法
Agnes Preethy H,Yanamandram Balasubramanian Venkatakrishnan,Vigneshwar Ramakrishnan et al.
Agnes Preethy H et al.
Brahmi Nei (BN), a traditional Indian polyherbal formulation has been described in classical texts for the treatment of anxiety and depression, as well as to fortify the immune system. The individual herbs of BN have been used for treatment...
The effect of phosphorylation on the conformational dynamics and allostery of the association of death-associated protein kinase with calmodulin [0.03%]
磷酸化对死亡相关蛋白激酶与钙调素结合的构象动力学和变构作用的影响
Xiaolong Li,Canglong Hou,Mingyuan Yang et al.
Xiaolong Li et al.
Protein phosphorylation plays an important role in the signal transduction and is capable of regulation of cell activity. The death-associated protein kinase 1 (DAPK1), as a Ser/Thr kinase, interacts with calmodulin (CaM) to regulate apopto...
Exploration of novel hydroxamate zinc binding group inhibitors against HDAC-1-3 enzymes by AI-based virtual screening: atomistic insights from steered molecular dynamics [0.03%]
基于AI虚拟筛选探索新型羟肟酸锌结合基团抑制剂对HDAC-1-3酶的抑制作用：从受控分子动力学中获得的原子视角分析
S M Esther Rubavathy,V Rajapandian,M Prakash
S M Esther Rubavathy
Overexpression of histone deacetylase (HDAC) enzymes is linked to a wide variety of illnesses, including malignancies and neurological disorders, which makes HDAC inhibitors potentially therapeutic. However, most HDAC inhibitors lack subcla...
Identification of a novel drug molecule for neurodegenerative disease from marine algae through in-silico analysis [0.03%]
通过计算机模拟分析从海洋藻类中鉴定出用于神经退行性疾病的新型药物分子
Anantha Krishnan Dhanabalan,Praveen Kumar,Saranya Vasudevan et al.
Anantha Krishnan Dhanabalan et al.
Cognitive functions are lost due to the rapid hydrolysis of acetylcholine including Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). Marine algae-derived compounds were reported for their neuroprotective activities and hence th...
Distinct characteristics of putative archaeal 5-methylcytosine RNA methyltransferases unveil their substrate specificities and evolutionary ancestries [0.03%]
假定的古菌5-甲基胞嘧啶RNA甲基转移酶的独特特征揭示了它们的底物特异性和进化祖先
Sayan Saha,Suraj Kumar Mandal,Shankar Prasad Kanaujia
Sayan Saha
5-Methylcytosine methyltransferases (m5C MTases) are known to be involved in the modification of RNA. Although these enzymes have been relatively well characterized in bacteria and eukarya, a complete understanding of the archaeal counterpa...
In silico development of a novel anti-mutation, multi-epitope mRNA vaccine against MPXV variants of emerging lineage and sub-lineages by using immunoinformatics approaches [0.03%]
使用免疫信息学方法开发新型抗变异多表位mRNA疫苗以对抗新兴谱系和亚谱系的MPXV的计算机模拟研究
Caixia Tan,Jingxiang Zhou,Anhua Wu et al.
Caixia Tan et al.
Over the past year, an unexpected surge in human monkeypox (hMPX) cases has been observed. This outbreak differs from previous ones, displaying distinct epidemiological characteristics and transmission patterns, believed to be influenced by...
Deep-VEGF: deep stacked ensemble model for prediction of vascular endothelial growth factor by concatenating gated recurrent unit with two-dimensional convolutional neural network [0.03%]
Deep-VEGF：通过门循环单元和二维卷积神经网络串联进行血管内皮生长因子预测的深度堆叠集成模型
Raed Alsini,Abdullah Almuhaimeed,Farman Ali et al.
Raed Alsini et al.
Vascular endothelial growth factor (VEGF) is involved in the development and progression of various diseases, including cancer, diabetic retinopathy, macular degeneration and arthritis. Understanding the role of VEGF in various disorders ha...