A novel stacking-based predictor for accurate prediction of antimicrobial peptides [0.03%]
一种新颖的基于堆叠模型的抗菌肽预测方法
Sameera Kanwal,Roha Arif,Saeed Ahmed et al.
Sameera Kanwal et al.
Antimicrobial peptides (AMPs) are gaining acceptance and support as a chief antibiotic substitute since they boost human immunity. They retain a wide range of actions and have a low risk of developing resistance, which are critical properti...
A review on expression and regulatory mechanisms of miR-337-3p in cancer [0.03%]
miR-337-3p在癌症中的表达及调控机制研究进展
Ghafour Yarahmadi,Sadegh Tavakoli Ataabadi,Zahra Dashti et al.
Ghafour Yarahmadi et al.
A group of diseases generally referred to as cancer represents a serious threat to people's health all over the world and has a significant negative influence on every aspect of the lives of patients. The development of cancer is influenced...
Enhanced sensing of bacteria biomarkers by ZnO and graphene oxide decorated PEDOT film [0.03%]
用于细菌生物标记物检测的ZnO和氧化石墨烯掺杂PEDOT膜传感器性能研究
Victor Malachy Udowo,Tomsmith O Unimuke,Hitler Louis et al.
Victor Malachy Udowo et al.
Developing a biofilm biomarker detector and inhibitor will immensely benefit efforts geared at curbing infectious diseases and microbiologically induced corrosion of medical implants, marine vessels and buried steel pipelines. N-Acyl homose...
Effect of Cu(II) compound containing dipicolinic acid on DNA damage: a study of antiproliferative activity and DNA interaction properties by spectroscopic, molecular docking and molecular dynamics approaches [0.03%]
含二吡啶甲酸的Cu(II)化合物对DNA损伤的影响：通过光谱、分子对接和分子动力学方法研究其抗增殖活性及DNA相互作用性质
Ameneh Heidari,Effat Dehghanian,Zohreh Razmara et al.
Ameneh Heidari et al.
A polymeric compound formulized as [Cu(µ-dipic)2{Na2(µ-H2O)4]n.2nH2O (I), where dipic is 2,6-pyridine dicarboxylic acid (dipicolinic acid, H2dipic), was synthesized by sonochemical irradiation. The initial in-vitro cytotoxic activity of t...
In silico screening of selective ATP mimicking inhibitors targeting the Plasmodium falciparum Grp94 [0.03%]
计算筛选抗疟药人工合成的ATP类似物抑制剂
Melissa Louise Stofberg,Florence Lisa Muzenda,Ikechukwu Achilonu et al.
Melissa Louise Stofberg et al.
Plasmodium falciparum parasites export more than 400 proteins to remodel the host cell environment and increase its chances of surviving and reproducing. The endoplasmic reticulum (ER) plays a central role in protein export by facilitating ...
An ensemble computational model for prediction of clathrin protein by coupling machine learning with discrete cosine transform [0.03%]
基于机器学习与离散余弦变换组合预测氯碱蛋白的集成计算模型
Majdi Khalid,Farman Ali,Wajdi Alghamdi et al.
Majdi Khalid et al.
Clathrin protein (CP) plays a pivotal role in numerous cellular processes, including endocytosis, signal transduction, and neuronal function. Dysregulation of CP has been associated with a spectrum of diseases. Given its involvement in vari...
Discovery of novel IDO1/TDO2 dual inhibitors: a consensus Virtual screening approach with molecular dynamics simulations, and binding free energy analysis [0.03%]
基于虚拟筛选及分子动力学模拟和结合自由能分析的新型IDO1/TDO2双靶点抑制剂的发现
Naufa Hanif,Suat Sari
Naufa Hanif
The pursuit of effective cancer immunotherapy drugs remains challenging, with overexpression of indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2) allowing cancer cells to evade immune attacks. While several IDO1 i...
Molecular insights into inhibiting effects of lignin on cellulase investigated by molecular dynamics simulation [0.03%]
分子模拟研究木质素抑制纤维素酶解的作用机制
Zhenjuan Chen,Qingwen Shi,Tengfei Zhao et al.
Zhenjuan Chen et al.
The hydrolysis of lignocellulose into fermentable monosaccharides using cellulases represents a critical stage in lignocellulosic bioconversion. However, the inactivation of cellulase in the presence of lignin is attributed to the high cost...
Unveiling therapeutic prospects: targeting MDM-2 in non-muscle invasive bladder cancer [0.03%]
揭示治疗前景：靶向非肌层浸润性膀胱癌中的MDM-2
Hongjian Wu,Hui Jin,Yongjian Cai
Hongjian Wu
Non-muscle invasive bladder cancer (NMIBC) is considered one of the most costly malignancies, requiring significant surgical and therapeutic measures. However, progression and non-responsiveness to immunotherapy are common outcomes of treat...
Unraveling the ligand specificity and promiscuity of the Staphylococcus aureus NorA efflux pump: a computational study [0.03%]
计算研究解开金黄色葡萄球菌NorA外排泵配体特异性及泛素性
Esra Büşra Işık,Onur Serçinoğlu
Esra Büşra Işık
Staphylococcus aureus, a gram-positive bacterial pathogen, develops antibiotic resistance partly through enhanced activity of transmembrane multi-drug efflux pump proteins like NorA. Being a prominent member of the Major Facilitator Superfa...