Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells [0.03%]
白细胞介素2介导的卵巢癌相关CD4+调节性T细胞向促炎症白细胞介素17产生型辅助性T细胞的转化
Lucie Leveque,Florence Deknuydt,Gilles Bioley et al.
Lucie Leveque et al.
Epithelial ovarian cancer (EOC) is a highly inflammatory malignancy, characterized by the presence, at the tumor site, of regulatory T cells (Treg) that suppress antitumor immunity. Recently, a new lineage of CD4+ T cells producing the proi...
Anna Karolina Palucka,Hideki Ueno,Joseph Fay et al.
Anna Karolina Palucka et al.
Cancer immunotherapy seeks to mobilize a patient's immune system for therapeutic benefit. It can be passive, that is, transfer of immune effector cells (T cells) or proteins (antibodies), or active, that is, vaccination. Early clinical tria...
Donor regulatory T cells identified by FoxP3 expression but also by the membranous CD4+CD127low/neg phenotype influence graft-versus-tumor effect after donor lymphocyte infusion [0.03%]
供体调节性T细胞通过FoxP3表达以及膜型CD4+CD127low/neg表型影响输注供体淋巴细胞后的移植物抗肿瘤效应
Yosr Hicheri,Abdelghani Bouchekioua,Yamina Hamel et al.
Yosr Hicheri et al.
Regulatory T cells (Treg) play a pivotal role in the control of graft-versus-host disease (GVHD) and might also influence the graft-versus-tumor effect after allogeneic stem cell transplantation. We assessed this role after donor lymphocyte...
A phase 1/2 study of autologous neuroblastoma tumor cells genetically modified to secrete IL-2 in patients with high-risk neuroblastoma [0.03%]
自体基因修饰的分泌IL-2神经母细胞瘤肿瘤细胞治疗高危神经母细胞瘤患者的I/II期临床试验
Heidi V Russell,Douglas Strother,Zhuyong Mei et al.
Heidi V Russell et al.
Autologous neuroblastoma (NB) tumor cells modified to secrete interleukin (IL)-2 (auto-IL-2) can be safely given to patients with advanced neuroblastoma and generate antitumor immune responses. As the benefits of tumor immunization may be g...
An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases [0.03%]
一种针对肿瘤胚胎抗原5T4的MVA疫苗在结直肠癌肝转移瘤患者手术治疗中的应用研究
Eyad Elkord,Adam Dangoor,Noel L Drury et al.
Eyad Elkord et al.
We investigated the use of a therapeutic vaccine, TroVax in patients undergoing surgical resection of colorectal cancer liver metastases. Systemic immunity generated by vaccination before and after resection of metastases was measured in ad...
Clinical-scale lentiviral vector transduction of PBL for TCR gene therapy and potential for expression in less-differentiated cells [0.03%]
临床规模的 Lentiviral 基因转移体系及在早期T细胞中的表达研究
Shicheng Yang,Steven A Rosenberg,Richard A Morgan
Shicheng Yang
In human gene therapy applications, lentiviral vectors may have advantages over gamma-retroviral vectors because of their ability to transduce nondividing cells, their resistance to gene silencing, and a lack of integration site preference....
Tumor antigen-specific T-cells are Present in the CD8alphaalpha+ T-cell effector-memory pool [0.03%]
肿瘤抗原特异性的T细胞存在于CD8alphalineagealpha效应记忆T细胞池中
Isabelle Magalhaes,Nalini Kumar Vudattu,Elke Jäger et al.
Isabelle Magalhaes et al.
CD8+ T-cell memory formation has recently been demonstrated to be associated with CD8alphaalpha homodimer expression by T-cells in mice. Up to now, the knowledge about the clinical significance of CD8alphaalpha+ T-cells in humans is limited...
Immune responses detected in urothelial carcinoma patients after vaccination with NY-ESO-1 protein plus BCG and GM-CSF [0.03%]
NY-ESO-1蛋白联合BCG和GM-CSF疫苗诱导膀胱癌患者产生免疫应答
Padmanee Sharma,Dean F Bajorin,Achim A Jungbluth et al.
Padmanee Sharma et al.
Urothelial carcinoma of the bladder is a solid tumor entity for which the immunomodulatory agent Bacillus-Calmette Guerin (BCG) has been shown to have substantial efficacy with approximately 90% cure rates in select patients with superficia...
Anisomycin inhibits the behaviors of T cells and the allogeneic skin transplantation in mice [0.03%]
安丝霉素通过抑制T细胞功能而削弱小鼠的移植排斥反应
Feiyue Xing,Zhe Yu,Jing Liu et al.
Feiyue Xing et al.
There is still a lack of a high potent and low toxic immunosuppressive drug. We accidentally found that a quite low dose of anisomycin was sufficient to block proliferation of T cells. In this study, carboxy-fluorescein diacetate-succinimid...
A novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells [0.03%]
一种新型的针对CD19的重组双特异性抗体衍生物可增强人类白血病细胞的免疫效应功能
Christian Kellner,Joerg Bruenke,Julia Stieglmaier et al.
Christian Kellner et al.
A novel bispecific antibody-derived recombinant protein targeting leukemias and lymphomas was designed, a single-chain Fv triple body (sctb) consisting of 1 polypeptide chain with 3 scFvs connected in tandem. The distal scFvs were specific ...