Infection-related Hospitalizations During Immune Checkpoint Inhibitor Treatment Without Immunosuppressants [0.03%]
未使用免疫抑制剂的免疫检查点抑制治疗期间与感染相关的住院治疗
Ye Sul Jeung,June Young Chun,Beom Kyu Choi et al.
Ye Sul Jeung et al.
Immunosuppressants are increasingly being used in the clinic to manage immune-related adverse effects. Consequently, the incidence of secondary infections associated with immunosuppression is increasing. However, little is known about prima...
Mucin-1-Targeted Chimeric Antigen Receptor T Cells Are Effective and Safe in Controlling Solid Tumors in Immunocompetent Host [0.03%]
针对粘蛋白-1的嵌合抗原受体T细胞在免疫功能正常的宿主中控制实体瘤是有效和安全的
Ru Zhou,Shu-Ta Wu,Mahboubeh Yazdanifar et al.
Ru Zhou et al.
The chimeric antigen receptor (CAR) T-cell therapy in solid epithelial tumors has been explored, however, with limited success. As much of the preclinical work has relied on xenograft models in immunocompromised animals, the immune-related ...
Nivolumab in Squamous Cell Carcinomas of the Head and Neck (SCCHN): A Real-world Outcome Study in Ontario, Canada [0.03%]
尼伏单抗在头颈部鳞状细胞癌（SCCHN）中的应用：来自加拿大安大略省的一项真实世界结果研究
Arman Zereshkian,Ruaa Shafi,Gregory R Pond et al.
Arman Zereshkian et al.
The CheckMate-141 trial led to the approval of nivolumab in platinum-resistant metastatic/advanced squamous cell carcinomas of the head and neck (SCCHN). We evaluated the outcomes of SCCHN patients in Ontario, Canada, treated with nivolumab...
Clinical Outcomes of PD-1/PD-L1 Inhibitors Among Patients With Advanced or Metastatic Non-Small Cell Lung Cancer With BRAF, ERBB2/HER2, MET , or RET Alterations: A Systematic Literature Review [0.03%]
程序性死亡配体1免疫检查点抑制剂治疗携带BRAF、ERBB2/HER2、MET或RET改变的晚期非小细胞肺癌患者的临床疗效：系统文献综述
Katherine G Akers,Sabine Oskar,Bin Zhao et al.
Katherine G Akers et al.
The therapeutic landscape for patients with advanced or metastatic non-small cell lung cancer (NSCLC) is rapidly evolving due to advances in molecular testing and the development of new targeted therapies and immunotherapies. However, the e...
The Proportion of Myeloid-derived Suppressor Cells in the Graft as a Potential Predictor of Acute Graft-versus-host Disease in Haploid Allogeneic Hematopoietic Stem Cell Transplantation [0.03%]
半相合造血干细胞移植中移植物来源的髓系抑制细胞预测急性移植物抗宿主病的价值探究
Junjie Cao,Renzhi Pei,Ying Lu et al.
Junjie Cao et al.
Myeloid-derived suppressor cells (MDSC) are powerful immunomodulatory cells that play an important role in infectious and inflammatory disorders, but the correlation between graft MDSC amount and early transplant outcomes remains unknown in...
LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis [0.03%]
肿瘤细胞来源的外泌体递送LOXL4通过激活STAT1/PD-L1轴促进肝癌免疫逃逸
Le Zhao,Ruifeng Pei,Yiren Ding et al.
Le Zhao et al.
Emerging evidence has validated that extracellular vesicles (EVs) regulate hepatocellular carcinoma (HCC) progression, while its role in HCC immune escape remains to be elucidated. This study investigates the role of EVs-encapsulated lysyl ...
Pathologic Complete Response After Gastric Artery Chemoembolization Combined With Tislelizumab for Neoadjuvant Therapy of Locally Advanced Gastric Cancer: A Case Report [0.03%]
局部晚期胃癌新辅助化疗联合替雷利珠单抗的病理完全缓解一例报告
Yufu Lin,Yabo Chen,Shenggan Lin et al.
Yufu Lin et al.
Gastric cancer is the most common type of gastrointestinal cancer in China which about 80% of patients are locally advanced or advanced when diagnosed. Surgery along brings high recurrence rate for locally advanced gastric cancer (LAGC), an...
Multiple Eruptive Keratoacanthomas Secondary to Nivolumab Immunotherapy [0.03%]
尼伏单抗免疫治疗诱发的多发性爆发性角弁瘤病病例报告
Eric Olsen,Steven A Svoboda,Marjorie Montanez-Wiscovich et al.
Eric Olsen et al.
Immune checkpoint inhibitors are increasingly being utilized for the treatment of advanced neoplastic disease and have been associated with wide-ranging cutaneous adverse effects. Though exceedingly rare, eruptive keratoacanthomas have been...
Core Needle Biopsies as an Alternative Source for Ex Vivo Expanded TIL for Adoptive Cell Therapy in Triple-Negative Breast Cancer [0.03%]
核心针活检作为三阴性乳腺癌适应性细胞治疗的体外扩增TILs的替代来源
Magdalena M Coman,Lajos Pusztai,Regina Hooley et al.
Magdalena M Coman et al.
Adoptive transfer of ex vivo expanded tumor-infiltrating lymphocytes (TILs) have produced long-term response in metastatic cancers. TILs have traditionally been expanded from surgically resected specimens. Ultrasound-guided core needle biop...
A New Method for Constructing Macrophage-Associated Predictors of Treatment Efficacy Based on Single-Cell Sequencing Analysis [0.03%]
基于单细胞测序分析的构建与巨噬细胞相关疗效预测因子的新方法
Jianxiu Lin,Yang Ran,Tengfei Wu et al.
Jianxiu Lin et al.
Tumor-associated macrophages (TAMs) are highly infiltrated in the tumor microenvironment (TME) of colorectal cancer (CRC) and play a vital role in CRC's development as well as prognosis. The required data were obtained from the Gene Express...