Wide diversity and complex evolution of M42 aminopeptidases with contrasted functional properties in Archaea [0.03%]
考古菌中功能迥异的M42氨基肽酶的广泛多样性和复杂进化历史
Emilie Chagny,Najwa Taib,Daphna Fenel et al.
Emilie Chagny et al.
M42 peptidases (TET) are ubiquitous, giant self-compartmentalized aminopeptidases forming unique tetrahedral structures. TETs may participate in protein homeostasis and amino acid recycling by processing peptides downstream of the proteasom...
Multiomic analyses reveal the molecular mechanisms of arid adaptation in a desert rodent species [0.03%]
多组学分析揭示了沙漠啮齿动物适应干旱的分子机制
Shuai Yuan,Rong Zhang,Yongling Jin et al.
Shuai Yuan et al.
Organisms living in desert habitats face multiple simultaneous pressures, such as high temperatures and arid, and the population dynamics and community diversity of small rodents are strongly affected by climate extremes. However, the poten...
Seasonal influenza viruses show distinct adaptive dynamics during growth in chicken eggs [0.03%]
季节性流感病毒在鸡胚中生长时表现出明显不同的适应性动态
Kathryn Kistler,Trevor Bedford
Kathryn Kistler
Human influenza viruses are grown in chicken eggs for vaccine production. Sequences of these egg-passaged viruses give us the opportunity to examine the evolution that occurs when these human viruses are subjected to the selective pressure ...
Functional determinants and evolutionary consequences of pleiotropy in complex and Mendelian traits [0.03%]
复杂性和单基因性状中的功能决定因子及遗传相关性的进化后果
Yury A Barbitoff,Polina M Bogaichuk,Nadezhda S Pavlova et al.
Yury A Barbitoff et al.
Pleiotropy, a phenomenon of multiple phenotypic effects of the same genetic alteration, is one of the most important features of genotype-to-phenotype networks. Over the last century, biologists have actively debated the prevalence, mechani...
Chromosome-level genome assembly of Eden's whale clarifies the taxonomy and speciation of Bryde's whale complex [0.03%]
基因组级别的 Eden 栖鸭鲸染色体装配弄清了 Bryde 浮游生物复杂分类学和物种形成的问题
Yi-Tao Lin,Fan Hui,Wentao Han et al.
Yi-Tao Lin et al.
Eden's whale (Balaenoptera edeni), a poorly understood baleen cetacean, has long been shrouded in taxonomic ambiguity due to limited genomic resources, obscuring its distinction from closely related species and its position within the cetac...
Tales of a Super Butterfly: Is Vanessa carye a Truly Migrant Species? Unraveling Migration Using Morphological and Genomics Approaches [0.03%]
超蝴蝶的故事：Vanessa carye真的是迁徙物种吗？利用形态学和基因组方法解开迁徙之谜
Amado Villalobos-Leiva,Enrique Rodriguez-Serrano,Franco Cruz-Jofré et al.
Amado Villalobos-Leiva et al.
Among movement strategies, migratory behavior is particularly intriguing in insects. Home-breeding is often permanent, and return journeys can take several generations. Although migration is crucial to the ecological and evolutionary proces...
From binding to catalysis: emergence of a rudimentary enzyme conferring intrinsic antibiotic resistance [0.03%]
从结合到催化：内在抗性抗生素的初级酶原型的出现
Claudèle Lemay-St-Denis,Stella Cellier-Goetghebeur,Maxime St-Aubin et al.
Claudèle Lemay-St-Denis et al.
How does enzymatic activity emerge? To shed light on this fundamental question, we study type B dihydrofolate reductases (DfrB), which were discovered for their role in antibiotic resistance. These rudimentary enzymes are evolutionarily dis...
Deciphering the impact of temperature on pleiotropic consequences of RNA polymerase mutations [0.03%]
揭秘RNA聚合酶突变多效性的温度效应
Deniz Ozbilek,Jake K Soley,Danna R Gifford et al.
Deniz Ozbilek et al.
Despite occurring in an essential molecule, mutations in RNA polymerase readily emerge and elicit complex pleiotropic effects across different levels of biological organization, which are all modulated by environment. We investigated the im...
MyESL: A software for evolutionary sparse learning in molecular phylogenetics and genomics [0.03%]
基于分子系统发育和基因组学的进化稀疏学习软件MYSL
Maxwell Sanderford,Sudip Sharma,Glen Stecher et al.
Maxwell Sanderford et al.
Evolutionary sparse learning (ESL) uses supervised machine learning to build evolutionary models where genomic sites and loci are parameters. It uses the Least Absolute Shrinkage and Selection Operator (LASSO) with bi-level sparsity to conn...
eccDNABase: a comprehensive and high-quality database for extrachromosomal circular DNA [0.03%]
eccDNA基底：一个全面且高质量的细胞外环状DNA数据库
Jin-Hao Zhang,Chang-Lin Yang,Chang-Yuan Ren et al.
Jin-Hao Zhang et al.
Extrachromosomal circular DNA (eccDNA) refers to small, circular DNA molecules that originate from chromosomal sequences and are prevalent across nearly all eukaryotic organisms. In humans, eccDNAs are widely distributed in normal tissues, ...