Palliative Chemotherapy is Well Tolerated in a Patient With Metastatic Colorectal Cancer Due to Bloom Syndrome With a Novel BLM Mutation [0.03%]
一例布卢姆综合征合并新型BLM基因突变结直肠癌患者的姑息性化疗治疗副词较小
Jacqueline Baca,Katherine Anderson,Thomas Lahiri et al.
Jacqueline Baca et al.
Background: Bloom syndrome is an autosomal recessive condition of genomic instability caused by increased sister-chromatid exchange, which results in a predisposition to a variety of cancers at a young age. The molecular ...
Autologous Cord Blood Transplantation for Idiopathic Severe Aplastic Anemia [0.03%]
自体脐血移植治疗难治性重型再生障碍性贫血
Anselm Chi-Wai Lee
Anselm Chi-Wai Lee
Cord blood units are seldom used for autologous transplantation and selection criteria have not been defined. A 6-year-old male with severe aplastic anemia received an autologous cord blood transplantation containing total nucleated cells (...
Standardized Neurologic Assessment Documentation for Daily Nelarabine Administration: A Bedside Questionnaire [0.03%]
用于nelarabeine日常给药的标准神经评估记录：一种床边问卷表
Andrew Wahba,Anil George,Eric S Schafer et al.
Andrew Wahba et al.
Nelarabine is an essential component in the treatment of pediatric T-cell lymphoblastic malignancies. Rare high-grade neurologic toxicities have been reported, but nelarabine discontinuation when early symptoms arise mitigates poor outcomes...
Hepatitis-Associated Aplastic Anemia in Children: Unraveling Clinical Mysteries in a Single-Center Case Series-More Questions Than Answers! [0.03%]
儿童肝炎相关再生障碍性贫血的临床特点及预后分析——单中心病例系列研究：更多疑问待解！
Muayad Alali,Kiet Tat,Kathleen Overholt
Muayad Alali
Hepatitis-associated aplastic anemia (HAAA) is a rare but potentially life-threatening form of acquired aplastic anemia. Since 2022, our center has observed an increase in HAAA cases. This study examines pediatric HAAA cases to enhance unde...
Moving the Needle Forward for Low-Risk and Intermediate-Risk Pediatric Rhabdomyosarcoma in LMIC: Outcomes From a Cancer Center in Pakistan [0.03%]
低危和中危儿童横纹肌肉瘤的治疗进展——来自巴基斯坦癌症中心的研究成果
Alina Sadaf,Sadia Anjum,Sana B Rizvi et al.
Alina Sadaf et al.
Pediatric rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. In low- and middle-income countries (LMIC) such as Pakistan, several challenges in the diagnosis and treatment of RMS may lead to poor outcomes. A retrospe...
Concomitant Azole Initiation Decreases Time to Stable Goal Sirolimus Concentrations in Pediatric Allogeneic Transplant Recipients [0.03%]
联合使用唑类药物可缩短儿科同种异体移植受者西罗莫司浓度达稳定的时长
Diana Wu,Megan R Williams,Akshay A Patwardhan et al.
Diana Wu et al.
Variability of sirolimus pharmacokinetics, often compounded by interactions with azole antifungal therapy, leads to concentrations outside the goal range and increased risk of related complications. We assessed the time to initial attainmen...
Naxitamab-combination Therapy for the Treatment of Patients With Refractory and/or Relapsed High-risk Neuroblastoma [0.03%]
纳西塔马布联合疗法治疗复发/难治高危神经母细胞瘤患者的疗效
Erin Murphy Trovillion,Meghan Michael,Lauren Brown et al.
Erin Murphy Trovillion et al.
Approved treatments for patients with refractory and/or relapsed (R/R) high-risk (HR) neuroblastoma are limited, and there is a need for new treatment combinations. In this case series, 4 patients were treated with the anti-GD2 monoclonal a...
Longitudinal Assessment of Health-Related Quality of Life in Childhood Acute Lymphoblastic Leukemia During Active Treatment in Indonesia [0.03%]
印度尼西亚儿童急性淋巴细胞白血病活动性治疗期间与健康相关的生活质量纵向评估
Braghmandita W Indraswari,Eddy Supriyadi,Gertjan J L Kaspers et al.
Braghmandita W Indraswari et al.
Children with acute lymphoblastic leukemia (ALL) are at risk for poor health-related quality of life (HRQOL) due to the treatment and disease itself. This study presents a serial measurement of the HRQOL of children with ALL during cancer t...
Clara Guilbault,Arnaud Bonnefoy,Georges-Étienne Rivard et al.
Clara Guilbault et al.
We report on a 10-year-old female diagnosed with severe congenital FV deficiency who developed anti-FV inhibitory antibody 3 weeks following dental procedure hemorrhage treated with FFP. The patient presented a large spontaneous gluteal hem...
The ETV6::NCOA2 Fusion, a Recurrent Cytogenetic Abnormality in Childhood Leukemia With Defining Properties [0.03%]
ETV6::NCOA2融合是一种具有特征性属性的儿童急性淋巴细胞白血病反复出现的染色体异常
Zayan Safi,Mahdi Fakhouri,Carla Monsef et al.
Zayan Safi et al.
t(8;12)(q13;p13)(ETV6::NCOA2) is a rare but recurrent cytogenetic abnormality in childhood leukemia with mixed myeloid/T-cell lineage. We hereby present the first pediatric B-ALL with ETV6::NCOA2. A 5-year-old boy presented with B-ALL resid...