Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major [0.03%]
布鲁西埃锥虫、克鲁齐锥虫和利什曼原鞭毛虫的糖核苷酸群
Daniel C Turnock,Michael A J Ferguson
Daniel C Turnock
The cell surface glycoconjugates of trypanosomatid parasites are intimately involved in parasite survival, infectivity, and virulence in their insect vectors and mammalian hosts. Although there is a considerable body of work describing thei...
Characterization of a novel gene for strain typing reveals substructuring of Aspergillus fumigatus across North America [0.03%]
表型特征的新基因分型方法揭示了北美地区烟曲霉的亚群结构
S Arunmozhi Balajee,Sun T Tay,Brent A Lasker et al.
S Arunmozhi Balajee et al.
Fifty-five epidemiologically linked Aspergillus fumigatus isolates obtained from six nosocomial outbreaks of invasive aspergillosis were subtyped by sequencing the polymorphic region of the gene encoding a putative cell surface protein, Afu...
Unusually low levels of genetic variation among Giardia lamblia isolates [0.03%]
溶组织内阿米巴分离株基因变异的不寻常水平偏高
Smilja Teodorovic,John M Braverman,Heidi G Elmendorf
Smilja Teodorovic
Giardia lamblia, an intestinal pathogen of mammals, including humans, is a significant cause of diarrheal disease around the world. Additionally, the parasite is found on a lineage which separated early from the main branch in eukaryotic ev...
Emma Levdansky,Jacob Romano,Yona Shadkchan et al.
Emma Levdansky et al.
Genes containing multiple coding mini- and microsatellite repeats are highly dynamic components of genomes. Frequent recombination events within these tandem repeats lead to changes in repeat numbers, which in turn alters the amino acid seq...
Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection [0.03%]
鉴定和表征CPS1作为参与新型隐球菌感染发病机制的透明质酸合酶的功能及特性
Ambrose Jong,Chun-Hua Wu,Han-Min Chen et al.
Ambrose Jong et al.
Cryptococcus neoformans is a pathogenic yeast that often causes devastating meningoencephalitis in immunocompromised individuals. We have previously identified the C. neoformans CPS1 gene, which is required for a capsular layer on the outer...
Mutual dependence of Candida albicans Est1p and Est3p in telomerase assembly and activation [0.03%]
端粒酶组装和激活中念珠菌端粒酶亚基Est1与Est3的相互依赖关系
Min Hsu,Eun Young Yu,Sunitha M Singh et al.
Min Hsu et al.
Telomerase is an RNA-protein complex responsible for extending one strand of the telomere terminal repeats. Analysis of the telomerase complex in budding yeasts has revealed the presence of one catalytic protein subunit (Est2p/TERT) and at ...
Trichoderma atroviride PHR1, a fungal photolyase responsible for DNA repair, autoregulates its own photoinduction [0.03%]
哈佐维德霉菌PHR1自身调控其自身的光诱导DNA修复作用
Gloria M Berrocal-Tito,Edgardo U Esquivel-Naranjo,Benjamin A Horwitz et al.
Gloria M Berrocal-Tito et al.
The photolyases, DNA repair enzymes that use visible and long-wavelength UV light to repair cyclobutane pyrimidine dimers (CPDs) created by short-wavelength UV, belong to the larger photolyase-cryptochrome gene family. Cryptochromes (UVA-bl...
Saccharomyces cerevisiae vacuole in zinc storage and intracellular zinc distribution [0.03%]
酿酒酵母锌贮藏和细胞内锌分布的液泡功能研究
Claudia Simm,Brett Lahner,David Salt et al.
Claudia Simm et al.
Previous studies of the yeast Saccharomyces cerevisiae indicated that the vacuole is a major site of zinc storage in the cell. However, these studies did not address the absolute level of zinc that was stored in the vacuole nor did they exa...
New Trypanosoma cruzi repeated element that shows site specificity for insertion [0.03%]
新型的恰加斯病原虫重复元件呈位点特异性插入特征
Renata T Souza,Márcia R M Santos,Fábio M Lima et al.
Renata T Souza et al.
A new family of site-specific repeated elements identified in Trypanosoma cruzi, which we named TcTREZO, is described here. TcTREZO appears to be a composite repeated element, since three subregions may be defined within it on the basis of ...
RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection [0.03%]
体内诱导RNA干扰突变体表明血流感期间锥虫鞭毛功能的必要性
Samantha Griffiths,Neil Portman,Philip R Taylor et al.
Samantha Griffiths et al.
We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure....