MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans [0.03%]
曲霉中的MPKA依赖型和非依赖型细胞壁信号转导路径
Tomonori Fujioka,Osamu Mizutani,Kentaro Furukawa et al.
Tomonori Fujioka et al.
Cell wall integrity signaling (CWIS) maintains cell wall biogenesis in fungi, but only a few transcription factors (TFs) and target genes downstream of the CWIS cascade in filamentous fungi are known. Because a mitogen-activated protein kin...
Capsule structural heterogeneity and antigenic variation in Cryptococcus neoformans [0.03%]
新型隐球菌的壳体结构异质性和抗原变异
Diane C McFadden,Bettina C Fries,Fang Wang et al.
Diane C McFadden et al.
Cryptococcus neoformans is a human pathogenic fungus with a capsule composed primarily of glucuronoxylomannan (GXM) that is important for virulence. Current views of GXM structure postulate a polymer composed of repeating mannose trisacchar...
Regulation of phosphoinositide levels by the phospholipid transfer protein Sec14p controls Cdc42p/p21-activated kinase-mediated cell cycle progression at cytokinesis [0.03%]
磷脂转移蛋白Sec14p通过调节磷脂肌醇水平控制细胞分裂末期Cdc42p/p21活化激酶介导的细胞周期进程
Alicia G Howe,Gregory D Fairn,Kendra MacDonald et al.
Alicia G Howe et al.
Sec14p is an essential phosphatidylcholine/phosphatidylinositol transfer protein with a well-described role in the regulation of Golgi apparatus-derived vesicular transport in yeast. Inactivation of the CDP-choline pathway for phosphatidylc...
Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion attenuates virulence in mice immunosuppressed with hydrocortisone [0.03%]
gliP缺失株菌的致病性降低表明gliotoxin是烟曲霉的主要毒力因子
Janyce A Sugui,Julian Pardo,Yun C Chang et al.
Janyce A Sugui et al.
Gliotoxin is an immunosuppressive mycotoxin long suspected to be a potential virulence factor of Aspergillus fumigatus. Recent studies using mutants lacking gliotoxin production, however, suggested that the mycotoxin is not important for pa...
Intracellular siderophores are essential for ascomycete sexual development in heterothallic Cochliobolus heterostrophus and homothallic Gibberella zeae [0.03%]
半知型Cochliobolus异形变种和同形型Gibberella具铁载体对于子实体分化之重要性研究
Shinichi Oide,Stuart B Krasnoff,Donna M Gibson et al.
Shinichi Oide et al.
Connections between fungal development and secondary metabolism have been reported previously, but as yet, no comprehensive analysis of a family of secondary metabolites and their possible role in fungal development has been reported. In th...
Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei [0.03%]
布鲁西费属衣原体进化上较为保守的蛋白质精氨酸N-甲基转移酶类型II
Deborah A Pasternack,Joyce Sayegh,Steven Clarke et al.
Deborah A Pasternack et al.
Protein arginine methylation is a posttranslational modification that impacts cellular functions, such as RNA processing, transcription, DNA repair, and signal transduction. The majority of our knowledge regarding arginine methylation deriv...
Development of a gene knockout system in Candida parapsilosis reveals a conserved role for BCR1 in biofilm formation [0.03%]
隐球菌模式物种解淀粉芽孢杆菌中基因敲除系统的建立及BCR1在生物被膜形成中的保守作用研究
Chen Ding,Geraldine Butler
Chen Ding
Candida parapsilosis is an important cause of candidiasis, yet few molecular tools are available. We adapted a recyclable nourseothricin resistance marker gene (SAT1) originally developed for use with C. albicans in order to generate gene k...
Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes [0.03%]
与哺乳动物过氧化物酶体和锥虫糖体膜蛋白质靶向有关的PEX19结合基元的保守性研究
Tracy Saveria,André Halbach,Ralf Erdmann et al.
Tracy Saveria et al.
Glycosomes are divergent peroxisomes found in trypanosomatid protozoa, including those that cause severe human diseases throughout much of the world. While peroxisomes are dispensable for both yeast (Saccharomyces cerevisiae and others) and...
Lia1p, a novel protein required during nuclear differentiation for genome-wide DNA rearrangements in Tetrahymena thermophila [0.03%]
参与四膜虫基因组范围DNA重排的核分化新蛋白Lia1p的功能研究
Charles H Rexer,Douglas L Chalker
Charles H Rexer
Extensive genome-wide rearrangements occur during somatic macronuclear development in Tetrahymena thermophila. These events are guided by RNA interference-directed chromatin modification including histone H3 lysine 9 methylation, which mark...
EstB-mediated hydrolysis of the siderophore triacetylfusarinine C optimizes iron uptake of Aspergillus fumigatus [0.03%]
EstB介导的铁载体三乙酰裸枝菌酸C的水解优化了烟曲霉的铁吸收
Claudia Kragl,Markus Schrettl,Beate Abt et al.
Claudia Kragl et al.
Aspergillus fumigatus excretes the fusarinine-type siderophore desferri-triacetylfusarinine C (DF-TafC) to mobilize iron. DF-TafC is a cyclic peptide consisting of three N(5)-cis-anhydromevalonyl-N(5)-hydroxy-N(2)-acetyl-l-ornithine residue...