Jason M Fritzler,Jason J Millership,Guan Zhu
Jason M Fritzler
We report the presence of a new fatty acyl coenzyme A (acyl-CoA) elongation system in Cryptosporidium and the functional characterization of the key enzyme, a single long-chain fatty acid elongase (LCE), in this parasite. This enzyme contai...
Hydrogen production by termite gut protists: characterization of iron hydrogenases of Parabasalian symbionts of the termite Coptotermes formosanus [0.03%]
福建引进散白蚁共生原生动物产氢及铁氢酶特性研究
Jun-Ichi Inoue,Kanako Saita,Toshiaki Kudo et al.
Jun-Ichi Inoue et al.
Cellulolytic flagellated protists in the guts of termites produce molecular hydrogen (H(2)) that is emitted by the termites; however, little is known about the physiology and biochemistry of H(2) production from cellulose in the gut symbiot...
Janine Bauer,Jürgen Wendland
Janine Bauer
Hyphal morphogenesis in Candida albicans is regulated by multiple pathways which act by either inducing or repressing filamentation. Most notably, Tup1, Nrg1, and Rfg1 are transcriptional repressors, while Efg1, Flo8, Cph1, and Czf1 can ind...
Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii [0.03%]
青蒿素通过钙依赖性机制诱导弓形虫蛋白分泌
Kisaburo Nagamune,Wandy L Beatty,L David Sibley
Kisaburo Nagamune
Intracellular calcium controls several crucial cellular events in apicomplexan parasites, including protein secretion, motility, and invasion into and egress from host cells. The plant compound thapsigargin inhibits the sarcoplasmic-endopla...
Transcriptional gene silencing reveals two distinct groups of Entamoeba histolytica Gal/GalNAc-lectin light subunits [0.03%]
转录基因沉默揭示出溶组织内阿米巴半乳糖/半乳糖-N-乙酰氨基葡萄糖低聚糖凝集素轻链亚基分为两个不同的组别
Rivka Bracha,Yael Nuchamowitz,Nomy Wender et al.
Rivka Bracha et al.
The Entamoeba histolytica cell surface Gal/GalNAc-inhibitable lectin is a heterodimer between a heavy (170 kDa) subunit linked via a disulfide bond to a light (31 to 35 kDa) subunit. Five light subunit genes with high homology have been ide...
Down-regulation of the trypanosomatid signal recognition particle affects the biogenesis of polytopic membrane proteins but not of signal peptide-containing proteins [0.03%]
调控沙微生物信号识别颗粒会影响多跨膜蛋白的生成但不影响信号肽包含蛋白质的产生
Yaniv Lustig,Yaron Vagima,Hanoch Goldshmidt et al.
Yaniv Lustig et al.
Protein translocation across the endoplasmic reticulum is mediated by the signal recognition particle (SRP). In this study, the SRP pathway in trypanosomatids was down-regulated by two approaches: RNA interference (RNAi) silencing of genes ...
Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway [0.03%]
histatin 5通过活化有丝分裂原活化蛋白激酶途径激活白色念珠菌的渗透压应答
Slavena Vylkova,Woong Sik Jang,Wansheng Li et al.
Slavena Vylkova et al.
Histatin 5 (Hst 5) is a salivary cationic peptide that has toxicity for Candida albicans by inducing rapid cellular ion imbalance and cell volume loss. Microarray analyses of peptide-treated cells were used to evaluate global gene responses...
Role of actin cytoskeletal dynamics in activation of the cyclic AMP pathway and HWP1 gene expression in Candida albicans [0.03%]
芽生型假丝酵母中环AMP信号途径活化和HWP1基因表达中的肌动蛋白细胞质骨架动态变化的作用研究
Michael J Wolyniak,Paula Sundstrom
Michael J Wolyniak
Changes in gene expression during reversible bud-hypha transitions of the opportunistic fungal pathogen Candida albicans permit adaptation to environmental conditions that are critical for proliferation in host tissues. Our previous work ha...
Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania [0.03%]
含有天冬氨酸的特异性半胱氨酸蛋白酶在致病性原生动物利什曼原虫程序性细胞死亡中的作用
Nancy Lee,Sreenivas Gannavaram,Angamuthu Selvapandiyan et al.
Nancy Lee et al.
In this report, we have characterized two metacaspases of Leishmania donovani, L. donovani metacaspase-1 (LdMC1) and LdMC2. These two proteins show 98% homology with each other, and both contain a characteristic C-terminal proline-rich doma...
Tudor nuclease genes and programmed DNA rearrangements in Tetrahymena thermophila [0.03%]
热转录因子核酸酶基因及四膜虫程序化DNA重排
Rachel A Howard-Till,Meng-Chao Yao
Rachel A Howard-Till
Proteins containing a Tudor domain and domains homologous to staphylococcal nucleases are found in a number of eukaryotes. These "Tudor nucleases" have been found to be associated with the RNA-induced silencing complex (A. A. Caudy, R. F. K...