Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum [0.03%]
潮霉素磷转移酶的表达改变了荚膜组织胞浆菌的致病性
A George Smulian,Reta S Gibbons,Jeffery A Demland et al.
A George Smulian et al.
The Escherichia coli hygromycin phosphotransferase (hph) gene, which confers hygromycin resistance, is commonly used as a dominant selectable marker in genetically modified bacteria, fungi, plants, insects, and mammalian cells. Expression o...
Kailash Gulshan,W Scott Moye-Rowley
Kailash Gulshan
Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes [0.03%]
调控锥虫血流期F-box蛋白mRNA表达的RNA结合蛋白TbUBP1和TbUBP2
Claudia Hartmann,Corinna Benz,Stefanie Brems et al.
Claudia Hartmann et al.
In the African trypanosome Trypanosoma brucei nearly all control of gene expression is posttranscriptional; sequences in the 3'-untranslated regions of mRNAs determine the steady-state mRNA levels by regulation of RNA turnover. Here we inve...
Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei [0.03%]
布氏锥虫鞭毛囊中的一种新的膜结合的eIF2α激酶
Maria Carolina S Moraes,Teresa C L Jesus,Nilce N Hashimoto et al.
Maria Carolina S Moraes et al.
Translational control mediated by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha) is central to stress-induced programs of gene expression. Trypanosomatids, important human pathogens, display different...
A chemogenomic screening of sulfanilamide-hypersensitive Saccharomyces cerevisiae mutants uncovers ABZ2, the gene encoding a fungal aminodeoxychorismate lyase [0.03%]
一种磺胺酸类药物高敏感性的酿酒酵母突变体的化学基因组筛选，发现了一种编码真菌氨脱氧犬尿氨酸裂解酶的ABZ2基因
Javier Botet,Laura Mateos,José L Revuelta et al.
Javier Botet et al.
Large-scale phenotypic analyses have proved to be useful strategies in providing functional clues about the uncharacterized yeast genes. We used here a chemogenomic profiling of yeast deletion collections to identify the core of cellular pr...
Requirement for Candida albicans Sun41 in biofilm formation and virulence [0.03%]
芽生菌白色假丝酵母菌Sun41蛋白在生物被膜形成及致病性中的作用要求
Carmelle T Norice,Frank J Smith Jr,Norma Solis et al.
Carmelle T Norice et al.
The cell wall of Candida albicans lies at the crossroads of pathogenicity and therapeutics. It contributes to pathogenicity through adherence and invasion; it is the target of both chemical and immunological antifungal strategies. We have i...
The fungus-specific HET domain mediates programmed cell death in Podospora anserina [0.03%]
鹤虱菌属特异性HET结构域介导_podospora anserina_程序性细胞死亡
M Paoletti,C Clavé
M Paoletti
Vegetative incompatibility is a programmed cell death reaction that occurs when fungal cells of unlike genotypes fuse. Genes defining vegetative incompatibility (het genes) are highly polymorphic, and most if not all incompatibility systems...
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity [0.03%]
恶性疟原虫Sir2：一种具有组蛋白去乙酰基酶和ADP核糖转移酶活性的非典型Sirtuin蛋白质
Catherine J Merrick,Manoj T Duraisingh
Catherine J Merrick
In the human malaria parasite Plasmodium falciparum, a member of the sirtuin family has been implicated in the epigenetic regulation of virulence genes that are vital to malaria pathogenesis and persistence. This eukaryotic sirtuin, PfSir2,...
Identification of an Entamoeba histolytica serine-, threonine-, and isoleucine-rich protein with roles in adhesion and cytotoxicity [0.03%]
黏附和细胞毒性的丝氨酸-苏氨酸-异亮氨酸富集蛋白的鉴定
Ryan C MacFarlane,Upinder Singh
Ryan C MacFarlane
Entamoeba histolytica is a leading cause of parasitic death globally. However, the molecular framework regulating pathogenesis is poorly understood. We have previously used expression profiling to identify Entamoeba genes whose expressions ...
Multiple modes of chromatin configuration at natural meiotic recombination hot spots in fission yeast [0.03%]
模式生物小核仁酵母中固有减数分裂重组热点的染色体构象分析
Kouji Hirota,Walter W Steiner,Takehiko Shibata et al.
Kouji Hirota et al.
The ade6-M26 meiotic recombination hot spot of fission yeast is defined by a cyclic AMP-responsive element (CRE)-like heptanucleotide sequence, 5'-ATGACGT-3', which acts as a binding site for the Atf1/Pcr1 heterodimeric transcription factor...