The Hottest Critical Care Research in the Blue Journal: Introduction to a Special Section [0.03%]
蓝色杂志最热门的重症监护研究：特刊介绍
Laurent Brochard,Carolyn S Calfee,Niall D Ferguson et al.
Laurent Brochard et al.
Switching to twice-yearly depemokimab from mepolizumab/benralizumab in severe asthma: A multicenter, randomized, double-blind, Phase 3A Clinical Trial (NIMBLE) [0.03%]
重度哮喘患者从美泊利单抗/贝那利尤单抗切换为每半年一次德普莫利单抗：一项多中心、随机、双盲的IIIa期临床试验（NIMBLE研究）
Geoffrey Chupp,Hiroyuki Nagase,Dirk Skowasch et al.
Geoffrey Chupp et al.
Rationale: Depemokimab is the first ultra-long-acting biologic with high interleukin-5 binding affinity, high potency, and an extended half-life enabling twice-yearly dosing. ...
Needle-based Confocal Laser Endomicroscopy-assisted Endobronchial Ultrasound-Guided Transbronchial Mediastinal Cryobiopsy [0.03%]
针式共聚焦激光内镜支气管超声引导经支气管纵隔冷冻活检术
Ziwen Zheng,Yunchao Su,Mingming Deng et al.
Ziwen Zheng et al.
Self-Propagating Nature of Pathogenic Extracellular Vesicles Associated with Smoking and COPD [0.03%]
与吸烟和慢性阻塞性肺疾病相关的病原性细胞外囊泡的自我传播特性
Camilla Margaroli,Kristopher R Genschmer,Ningyong Xu et al.
Camilla Margaroli et al.
Rationale: In chronic obstructive pulmonary disease (COPD), neutrophil (PMN)-derived neutrophil elastase positive (NE+) extracellular vesicles (EVs) induce many of the pathologic features of the disorder, including emphys...
Dandan Li,Min Peng,Zhiwei Wang et al.
Dandan Li et al.
Risk Averse: Assessing Risk as a Surrogate Measure in Pulmonary Arterial Hypertension [0.03%]
谨慎为上：评估肺动脉高压中的风险替代指标
Aparna Balasubramanian,Stephen C Mathai
Aparna Balasubramanian
Recombinant human IGF-1 complex preserves lung development in mechanically ventilated preterm lambs [0.03%]
重组人生长素IGF-1复合物可保持机械通气早产绵羊的肺部发育
Kurt H Albertine,Andrew Rebentisch,Elaine Dawson et al.
Kurt H Albertine et al.
Rationale: Bronchopulmonary dysplasia is associated with low concentrations of insulin-like growth factor-1 (IGF-1) protein in preterm infants. Postnatal replenishment of IGF-1 protein is a potential approach to prevent t...
Fractional Exhaled Nitric Oxide as a Novel Biomarker of Relapse in Eosinophilic Granulomatosis with Polyangiitis [0.03%]
呼出一氧化氮作为肉芽肿性多血管炎复发的新生物标志物
Francesca Cefaloni,Anne-Catherine Maynard-Paquette,Ajerico Del Rosario et al.
Francesca Cefaloni et al.
Study of Risk Assessment Scores as Surrogate Endpoints in Pulmonary Arterial Hypertension Trials [0.03%]
肺动脉高压临床试验中的风险评估评分作为替代终点的研究
Yongqi Liu,R James White,Sang Wan Lee et al.
Yongqi Liu et al.
Rationale: Pulmonary arterial hypertension (PAH) clinical trials largely rely on clinically-relevant intermediate outcomes, as mortality and lung transplant are infrequent and remote outcomes. The change in 6-minute walk ...
Lung stress mapping: An innovative technology to visualize the hidden risk of ventilator-induced lung injury [0.03%]
肺应力成像：一种可视化通气相关性肺损伤风险的创新技术
Takashi Maezawa,Taiki Hoshino,Andi Muhammad Fadlillah Firstiogusran et al.
Takashi Maezawa et al.
Rationale: Conventional monitoring of acute respiratory distress syndrome (ARDS) relies on global parameters, e.g., tidal volume, airway pressure, and driving pressure. These parameters do not capture regional stress hete...