Megan R Miller,Paul Nyirjesy
Megan R Miller
Trichomonas vaginalis, a common pathogen, remains widely unknown to the public. Its clinical consequences include upper genital tract infection, increased risk of preterm delivery, and increased risk of HIV transmission. Diagnostic tests, e...
Lindsay E Nicolle
Lindsay E Nicolle
Urinary tract infection remains a common problem for many populations. Recent studies have expanded our understanding of the host innate immune response and its role in the familial association observed for recurrent uncomplicated urinary t...
Suzanne Zane,Jeannette Guarner
Suzanne Zane
Clostridial toxic shock, caused by Clostridium sordellii or Clostridium perfringens, is a rare and largely fatal syndrome among reproductive-aged women with genital tract infection, and may occur following various pregnancy outcomes or with...
Willize E van der Starre,Jaap T van Dissel,Cees van Nieuwkoop
Willize E van der Starre
Although febrile urinary tract infections (UTIs) are relatively common in adults, data on optimal treatment duration are limited. Randomized controlled trials specifically addressing the elderly and patients with comorbidities have not been...
Subhashis Mitra,George John Alangaden
Subhashis Mitra
Urinary tract infections (UTIs) are the most common infectious complication after kidney transplantation (KT). Recurrent UTIs after KT can contribute to increased morbidity and may also be associated with graft loss and mortality. Though se...
Carolyn Gardella
Carolyn Gardella
Genital herpes is a common sexually transmitted disease that is frequently undiagnosed. Viral shedding occurs frequently and often without symptoms facilitating transmission to sex partners. Genital herpes may impact HIV transmission, and m...
Frederiek D&#x;Hondt,Karel Everaert
Frederiek D&#x;Hondt
Spinal cord injuries (SCI) result in different lower urinary tract dysfunctions. Because of both the disease and the bladder drainage method, urinary tract infections (UTIs) are one of the most frequent conditions seen in SCI patients. Diag...
Early and adequate antibiotic therapy in the treatment of severe sepsis and septic shock [0.03%]
早期充分的抗感染治疗在重症脓毒症及脓毒性休克中的作用
John D Dickinson,Marin H Kollef
John D Dickinson
Severe sepsis and septic shock are conditions that pose difficult challenges to physicians and the health care system. In the past 10 years, a number of retrospective and prospective observational studies have shed light on the importance o...
Appropriate antibiotic dosage levels in the treatment of severe sepsis and septic shock [0.03%]
严重脓毒症和感染性休克抗微生物治疗的抗生素适宜剂量水平分析
Fabio Silvio Taccone,Maya Hites,Marjorie Beumier et al.
Fabio Silvio Taccone et al.
Antibiotic treatment of critically ill patients remains a significant challenge. Optimal antibacterial strategy should achieve therapeutic drug concentration in the blood as well as the infected site. Achieving therapeutic drug concentratio...
When and how to cover for resistant gram-negative bacilli in severe sepsis and septic shock [0.03%]
何时以及如何对抗重度脓毒症和感染性休克中的耐药革兰阴性杆菌进行覆盖抗菌治疗
Håkan Hanberger,Christian G Giske,Helen Giamarellou
Håkan Hanberger
In the 80s and 90s, increasing antibiotic resistance was met by the introduction of new effective agents with broader antibacterial spectra for the empirical treatment of severe infections. In recent years, however, few novel antimicrobials...