Robert C Kalayjian
Robert C Kalayjian
Kidney disease is more prevalent among persons living with HIV, and may arise from a combination of comorbidities, co-infections, and medication-associated toxicities. Additional effects of HIV-1 viral replication, immunodeficiency and gene...
Ana A Weil,Louise C Ivers,Jason B Harris
Ana A Weil
Cholera is an acute, severe diarrheal disease caused by Vibrio cholerae that affects millions of people each year. Without prompt rehydration, death can occur within hours of the onset of symptoms. In October 2010, cholera emerged in Haiti,...
Hemant Kulkarni,Manju Mamtani,Archana Patel
Hemant Kulkarni
Zinc has caught wide scientific attention for the conceptual promise it has to offer for prevention, control and treatment of acute diarrhea. This review focuses on the mechanisms by which zinc might contribute to the pathogenesis of acute ...
Katherine Huppler Hullsiek,Birgit Grund
Katherine Huppler Hullsiek
Selecting the primary endpoint is one of the most important decisions in designing clinical trials. Many HIV trials are powered for surrogate markers, often virologic suppression. Among 49 recently published Phase 3 or higher randomized HIV...
Grazia Anna Niro,Antonina Smedile
Grazia Anna Niro
Hepatitis delta virus (HDV) is a unique human virus, showing similarities with plant viroids. Although impressive knowledge on virus structure and replication has been achieved, several questions like HBV/HDV interaction and post translatio...
Bruce L Gilliam,Devang Patel,Rohit Talwani et al.
Bruce L Gilliam et al.
Africa carries a disproportionate burden of the global HIV endemic, accounting for two thirds of the global 33.3 million people living with HIV. While tremendous advances have been made in addressing the HIV epidemic in Africa, considerable...
The role of innate immunity in the host defense against intestinal bacterial pathogens [0.03%]
先天性免疫在肠道细菌病原体宿主防御中的作用
John Sotolongo,Jose Ruiz,Masayuki Fukata
John Sotolongo
Eradication of infectious disease is our global health challenge. After encountering intestinal infection with a bacterial pathogen, the host defense program is initiated by local antigen-presenting cells (APCs) that eliminate invading path...
Valerie E Stone
Valerie E Stone
The clinical issues affecting women with HIV/AIDS differ little from those affecting men. However, current research shows that treatment and outcome disparities affect many women with HIV, hypothesized to result from a complex interplay of ...
Important Drug-Drug Interactions in HIV-Infected Persons on Antiretroviral Therapy: An Update on New Interactions Between HIV and Non-HIV Drugs [0.03%]
抗逆转录病毒治疗患者的重要药物相互作用：人类免疫缺陷病毒和其他非人类免疫缺陷病毒药物之间新相互作用的更新报告
Alice Tseng,Michelle Foisy
Alice Tseng
Advances in antiretroviral therapy have turned HIV into a chronic, manageable disease. Patients often require treatment for co-morbid conditions as well as HIV, and consequently, pharmacokinetic interactions between antiretrovirals (ARVs) a...
Subhashis Mitra,Lawrence Crane
Subhashis Mitra
Rare in the general population, anal cancer has reached epidemic proportions among HIV-infected men who have sex with men (MSM). These cancers are human papillomavirus (HPV)-associated, usually HPV type16, and are analogous to cervical canc...