Optimizing biologic therapies for inflammatory bowel disease (ulcerative colitis and Crohn's disease) [0.03%]
生物制剂治疗炎症性肠病（溃疡性结肠炎和克罗恩病）的优化
Marc Ferrante,Geert D&#x;Haens,Paul Rutgeerts et al.
Marc Ferrante et al.
The introduction of biologic agents and particularly of anti-tumor necrosis factor antibodies dramatically changed the therapeutic algorithm in patients with inflammatory bowel diseases. Although the efficacy of these agents has been demons...
Miles P Sparrow,Peter M Irving,Stephen B Hanauer
Miles P Sparrow
Conventional therapies remain the mainstay of treatment for most patients with inflammatory bowel disease (IBD), with only a minority of patients requiring biologic therapies. Recently, attention has focused on optimizing dosing strategies ...
Diagnostic advances in inflammatory bowel disease (imaging and laboratory) [0.03%]
炎症性肠病的诊断进展（影像学和实验室检查）
Maria E Moscandrew,Edward V Loftus Jr
Maria E Moscandrew
Autoimmune and antimicrobial antibodies currently play only an adjunctive role in the diagnosis of inflammatory bowel disease (IBD). Their sensitivity and specificity are not high enough to be relied upon alone to secure a diagnosis; howeve...
Morten H Vatn
Morten H Vatn
Inflammatory bowel diseases (IBD), mainly ulcerative colitis and Crohn's disease, are chronic, heterogenic, lifelong illnesses with young age of onset and a great potential for disability. The natural history of these diseases is influenced...
David Q Shih,Stephan R Targan
David Q Shih
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder caused by dysregulated immune responses in a genetically predisposed individual. Recent accumulating data, i...
Kevin A Ghassemi,Thomas O G Kovacs,Dennis M Jensen
Kevin A Ghassemi
Upper gastrointestinal bleeding from peptic ulcer disease is a common clinical event, resulting in considerable patient morbidity and significant health care costs. Inhibiting gastric acid secretion is a key component in improving clinical ...
George Sachs,Yi Wen,David R Scott
George Sachs
Helicobacter pylori infection causes chronic active gastritis, ulcer disease, and gastric cancer. Current eradication regimens use a proton pump inhibitor (PPI) and two antibiotics. Triple therapy now has a success rate less than 80%, below...
Regulation of food intake: the gastric X/A-like endocrine cell in the spotlight [0.03%]
进食调控：胃X/A样内分泌细胞受关注
Andreas Stengel,Yvette Taché
Andreas Stengel
Nutritional status influences hormone secretion from specialized enteroendocrine cells within the gut mucosa. These hormones regulate food intake by mediating information to central neurocircuitries in the brainstem and forebrain (eg, hypot...
Gut sensing mechanisms [0.03%]
肠道感知机制
Arushi deFonseka,Jonathan Kaunitz
Arushi deFonseka
The mechanisms by which the gut senses and responds to nutrients involve the interplay of multiple complex pathways. In addition to regulating digestion and absorption, the pathways stimulated by molecules in the gut lumen mediate gastric m...
Nauramy Osefo,Tetsuhide Ito,Robert T Jensen
Nauramy Osefo
Gastric acid hypersecretory states are characterized by basal hypersecretion of gastric acid and historically include disorders associated with hypergastrinemia, hyperhistaminemia, and those of unknown etiology. Although gastric acid secret...