Sascha Kopic,John P Geibel
Sascha Kopic
Acid-related disorders represent a major healthcare concern. In recent years, our understanding of the physiologic processes underlying gastric acid secretion has improved notably. The identity of several apical ion transport proteins, whic...
Enteric nervous system in the small intestine: pathophysiology and clinical implications [0.03%]
小肠的肠神经系统：病理生理及临床意义
Behtash Ghazi Nezami,Shanthi Srinivasan
Behtash Ghazi Nezami
The digestive system is endowed with its own, local nervous system, referred to as the enteric nervous system (ENS). Given the varied functions of small intestine, its ENS has developed individualized characteristics relating to motility, s...
Joseph H Sellin
Joseph H Sellin
Mast cells [0.03%]
mast细胞
Terez Shea-Donohue,Jennifer Stiltz,Aiping Zhao et al.
Terez Shea-Donohue et al.
Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identi...
Joseph M Pickard,Alexander V Chervonsky
Joseph M Pickard
Sampling of intestinal pathogens and commensals is an important aspect of the gut immune system, and is accomplished through the action of specialized epithelial M cells. Although their sampling abilities have been appreciated for decades, ...
Intestinal goblet cells and mucins in health and disease: recent insights and progress [0.03%]
肠道杯状细胞和黏蛋白的健康与疾病：最新的见解和进展
Young S Kim,Samuel B Ho
Young S Kim
The mucus layer coating the gastrointestinal tract is the front line of innate host defense, largely because of the secretory products of intestinal goblet cells. Goblet cells synthesize secretory mucin glycoproteins (MUC2) and bioactive mo...
Eduardo A Bonin,Todd H Baron
Eduardo A Bonin
Self-expandable metal stent (SEMS) placement is a minimally invasive option for achieving acute colonic decompression in obstructed colorectal cancer. Colorectal stenting offers nonoperative, immediate, and effective colon decompression and...
Noriaki Manabe,Archana S Rao,Banny S Wong et al.
Noriaki Manabe et al.
New therapies are being developed for irritable bowel syndrome (IBS). These advances are based on understanding pathophysiology or the development of medications with greater selectivity in classes of agents with known efficacy. Prucaloprid...
Functional abdominal pain [0.03%]
功能性腹痛
Madhusudan Grover,Douglas A Drossman
Madhusudan Grover
Functional abdominal pain syndrome (FAPS) is a relatively less common functional gastrointestinal (GI) disorder defined by the presence of constant or frequently recurring abdominal pain that is not associated with eating, change in bowel h...
Jason Hemming,Martin Floch
Jason Hemming
Diverticular disease is one of the most prevalent gastrointestinal conditions to afflict Western populations. Although the majority of patients with diverticulosis remain asymptomatic, about one third will develop symptoms at some point in ...