Sunanda Kane
Sunanda Kane
The decision to start immunosuppressive therapy comes with benefits and risks. Patient selection is as important as medication selection, because some patients are not appropriate for certain therapies. The decision is based on many factors...
Udayakumar Navaneethan,Bo Shen
Udayakumar Navaneethan
Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has become the surgical treatment of choice for patients with medically refractory ulcerative colitis (UC) or UC with dysplasia and for the majority of patients with famil...
Poonam Beniwal,Laura Harrell
Poonam Beniwal
Inflammatory bowel disease (IBD), which includes ulcerative colitis, Crohn's disease, and indeterminate colitis, is characterized by chronic inflammation of the digestive tract and has a significant impact on quality of life. Coupled with c...
Brian S Sheridan,Leo Lefrançois
Brian S Sheridan
The mucosal immune system is constantly exposed to a wide range of commensal and potentially pathogenic microbial species. Chronic exposure to foreign organisms makes generation of an appropriate immune response critical in maintaining a ba...
Christina Ha,Asher Kornbluth
Christina Ha
The definition of remission in Crohn's disease and ulcerative colitis has evolved to include mucosal healing as a measure of treatment efficacy. Randomized, controlled trials have demonstrated mucosal healing is attainable with the current ...
Association of long-term proton pump inhibitor therapy with bone fractures and effects on absorption of calcium, vitamin B12, iron, and magnesium [0.03%]
长期使用质子泵抑制剂与骨骨折的关系及其对钙、维生素B12、铁和镁吸收的影响
Tetsuhide Ito,Robert T Jensen
Tetsuhide Ito
Proton pump inhibitors (PPI) are one of the most widely used classes of drugs. PPIs have a very favorable safety profile, and it is unusual for a patient to stop them because of side effects. However, with increasing numbers of patients chr...
The aging colon: the role of enteric neurodegeneration in constipation [0.03%]
老化结肠：肠道神经退行性病变在便秘中的作用
Brandt Wiskur,Beverley Greenwood-Van Meerveld
Brandt Wiskur
Constipation is a common problem in the elderly, and abnormalities in the neural innervation of the colon play a significant role in abnormalities in colonic motility leading to delayed colonic transit. The scope of this review encompasses ...
Charles N Bernstein
Charles N Bernstein
In this article, the recent literature exploring the epidemiology of inflammatory bowel disease (IBD) is reviewed. Epidemiologic studies present data on disease burden, but may also provide clues to disease etiology. The emergence of IBD in...
Clinical trial report: Eradication of Helicobacter pylori reduces the risk for subsequent gastric cancer [0.03%]
根除幽门螺旋杆菌可降低今后患胃癌的风险
Joseph R Pisegna,Bijal Surti,David R Scott
Joseph R Pisegna
Symptoms and reflux in infants: Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R)--utility for symptom tracking and diagnosis [0.03%]
婴幼儿胃食管反流症状与反流：修订版婴儿胃食管反流问卷(I-GERQ-R)在症状监测和诊断中的应用价值
Susan R Orenstein
Susan R Orenstein
Answering a need for a thoroughly validated infant gastroesophageal reflux questionnaire, the Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R) was designed, refined, and validated using state-of-the-art psychometric methods. ...