Amy N Sussman,Thomas D Boyer
Amy N Sussman
One of the most common manifestations of the development of portal hypertension in the patient with cirrhosis is the appearance of ascites. Once ascites develops, the prognosis worsens and the patient becomes susceptible to complications su...
Ben Lawrence,Mark Kidd,Bernhard Svejda et al.
Ben Lawrence et al.
The incidence of gastric neuroendocrine tumors (NETs) has increased exponentially based on widespread use of endoscopy and a greater pathological awareness of the condition. A key concern is the potential association with hypergastrinemia i...
The IL-28 genotype: how it will affect the care of patients with hepatitis C virus infection [0.03%]
IL-28基因分型及其对丙肝患者的临床指导意义
Brian L Pearlman
Brian L Pearlman
The hypothesis that host genetics play an essential role in the ability not only to clear acute hepatitis C infection but also to achieve sustained virologic response (SVR) to interferon (IFN)-based therapy has been proved with the recent d...
Fred Poordad
Fred Poordad
The story of hepatitis C virus (HCV) therapy is about to add one of its biggest chapters. From the serendipitous beginnings in the 1980s when investigators noted that interferon improves liver enzymes in non-A, non-B hepatitis, to the disco...
Haripriya Maddur,Naga Chalasani
Haripriya Maddur
Drug-induced liver injury (DILI) is a rare but potentially devastating adverse drug reaction. Its presentation can range from asymptomatic elevation in liver biochemistries to fulminant liver failure. Over the past decade, clinical and rese...
Prevention and treatment of postoperative Crohn's disease recurrence: an update for a new decade [0.03%]
克罗恩病术后复发的预防和治疗：新十年的更新意见
Marc Schwartz,Miguel Regueiro
Marc Schwartz
Poorly controlled Crohn's disease (CD) often requires surgery for such complications as strictures, fistulas, and abscesses. The goal of postoperative treatment is to suppress or prevent inflammation and maintain mucosal healing. Probiotics...
Tyralee Goo,Yasutada Akiba,Jonathan D Kaunitz
Tyralee Goo
Luminal amino acids and lack of luminal acidity as a result of acid neutralization by intragastric foodstuffs are powerful signals for acid secretion. Although the hormonal and neural pathways underlying this regulatory mechanism are well u...
Elizabeth Mileti,Philip Rosenthal
Elizabeth Mileti
Management of portal hypertension in children has evolved over the past several decades. Portal hypertension can result from intrahepatic or extrahepatic causes. Management should be tailored to the child based on the etiology of the portal...
George Sachs,Jai Moo Shin,Richard Hunt
George Sachs
The gastric H,K-adenosine triphosphatase (ATPase) is the primary target for treatment of acid-related diseases. Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK(a) of about 4.0 ...
Jennifer Y Montgomery,Jasmohan S Bajaj
Jennifer Y Montgomery
Minimal hepatic encephalopathy (MHE) is a neurocognitive disorder that affects up to 80% of cirrhotic patients. Similar to overt hepatic encephalopathy, ammonia and oxidative stress play key roles in the pathogenesis of MHE. However, MHE is...