Lead Poisoning [0.03%]
铅中毒
Bruce Lanphear,Ana Navas-Acien,David C Bellinger
Bruce Lanphear
Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis [0.03%]
重度髋关节骨关节炎患者应进行全髋置换还是抗阻训练？
Thomas Frydendal,Robin Christensen,Inger Mechlenburg et al.
Thomas Frydendal et al.
Background: Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking regarding comparison of the effectiveness of this procedure with that of nonsurgical tr...
Randomized Controlled Trial
The New England journal of medicine. 2024 Oct 31;391(17):1610-1620. DOI:10.1056/NEJMoa2400141 2024
Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer [0.03%]
PIK3CA突变的晚期乳腺癌患者的inavolisib治疗
Nicholas C Turner,Seock-Ah Im,Cristina Saura et al.
Nicholas C Turner et al.
Background: Inavolisib is a highly potent and selective inhibitor of the alpha isoform of the p110 catalytic subunit of the phosphatidylinositol 3-kinase complex (encoded by PIK3CA) that also promotes the degradation of m...
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis [0.03%]
肥胖且患有膝关节骨性关节炎的人群中的每周一次司美格鲁肽疗法
Henning Bliddal,Harold Bays,Sébastien Czernichow et al.
Henning Bliddal et al.
Background: Weight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of glucagon-like peptide-1 receptor agonists on outcomes in knee osteoarthritis among persons wit...
Rebecca T Hahn,Raj Makkar,Vinod H Thourani et al.
Rebecca T Hahn et al.
Background: Severe tricuspid regurgitation is associated with disabling symptoms and an increased risk of death. Data regarding outcomes after percutaneous transcatheter tricuspid-valve replacement are needed. ...
Patrick T O&#x;Gara
Patrick T O&#x;Gara
Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis [0.03%]
无症状重度主动脉瓣狭窄的经导管主动脉瓣植入术
Philippe Généreux,Allan Schwartz,J Bradley Oldemeyer et al.
Philippe Généreux et al.
Background: For patients with asymptomatic severe aortic stenosis and preserved left ventricular ejection fraction, current guidelines recommend routine clinical surveillance every 6 to 12 months. Data from randomized tri...
APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans [0.03%]
西非人群APOL1双等位基因和单等位基因突变与慢性肾脏病的关系
Rasheed A Gbadegesin,Ifeoma Ulasi,Samuel Ajayi et al.
Rasheed A Gbadegesin et al.
Background: Apolipoprotein L1 gene (APOL1) variants are risk factors for chronic kidney disease (CKD) among Black Americans. Data are sparse on the genetic epidemiology of CKD and the clinical association of APOL1 variant...
Zhigang Yang,Jie Deng
Zhigang Yang
Liam G McCoy,Arjun K Manrai,Adam Rodman
Liam G McCoy