Daniela Kroshinsky,Adela Rambi G Cardones,Kimberly G Blumenthal
Daniela Kroshinsky
Jaison Barreto,Patricia Sammarco Rosa,Linda Adams et al.
Jaison Barreto et al.
Background: Standard multidrug therapy for leprosy may be associated with severe side effects, which add to the stigma and discrimination that affect persons with the disease. In addition, the threat posed by drug-resista...
Axillary Surgery in Breast Cancer - Primary Results of the INSEMA Trial [0.03%]
腋窝手术乳腺癌患者的INSEMA试验初步结果
Toralf Reimer,Angrit Stachs,Kristina Veselinovic et al.
Toralf Reimer et al.
Background: Whether surgical axillary staging as part of breast-conserving therapy can be omitted without compromising survival has remained unclear. Meth...
Imlunestrant with or without Abemaciclib in Advanced Breast Cancer [0.03%]
Imlunestrant联合或不联合Abemaciclib治疗晚期乳腺癌
Komal L Jhaveri,Patrick Neven,Monica Lis Casalnuovo et al.
Komal L Jhaveri et al.
Background: Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen-receptor (ER) degrader that delivers continuous ER inhibition, even in cancers with mutations in the gene encoding ERα (ESR1). ...
Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A [0.03%]
HIV- lentiviral 基因治疗CD34+造血细胞治疗甲型血友病临床试验
Alok Srivastava,Aby Abraham,Fouzia Aboobacker et al.
Alok Srivastava et al.
Background: Severe hemophilia A is managed with factor VIII replacement or hemostatic products that stop or prevent bleeding. Data on gene therapy with hematopoietic stem-cell (HSC)-based expression of factor VIII for the...
Could Lentivirus Overcome the AAV Gene-Therapy Challenges in Hemophilia A? [0.03%]
慢病毒能否克服AAV基因疗法在甲型血友病中的挑战？
Johnny Mahlangu
Johnny Mahlangu
Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage [0.03%]
动脉瘤性蛛网膜下腔出血的输血策略宜宽松还是严格
Shane W English,Anthony Delaney,Dean A Fergusson et al.
Shane W English et al.
Background: The effect of a liberal red-cell transfusion strategy as compared with a restrictive strategy in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear. ...
Long-Acting HIV Medicines and the Pandemic Inequality Cycle - Rethinking Access [0.03%]
长效型艾滋药物与疫情不平等循环——重新思考药品可及性问题
Winnie Byanyima,Linda-Gail Bekker,Matthew M Kavanagh
Winnie Byanyima
Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma [0.03%]
达雷妥尤单抗与活动性监测治疗高危冒烟型多发性骨髓瘤的比较效果：3期临床试验
Meletios A Dimopoulos,Peter M Voorhees,Fredrik Schjesvold et al.
Meletios A Dimopoulos et al.
Background: Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma, a precursor d...
Mark Earnest
Mark Earnest