De-escalated Management of HPV-positive Oropharyngeal Carcinoma: Improving Outcomes with Personalized Approaches [0.03%]
HPV阳性口腔癌的降级管理：通过个性化方法改善预后
Irini Yacoub,Achraf Shamseddine,Joshua Qian et al.
Irini Yacoub et al.
Human papilloma virus (HPV)-positive oropharyngeal cancer (OPC) is increasingly prevalent and has a favorable prognosis compared to HPV-negative OPC and other head and neck malignancies associated with smoking and alcohol. De-escalation of ...
Principles and Paradigms of De-Escalated Elective Nodal Irradiation: Boldly Going Towards an Inflection Point in Head and Neck Radiotherapy [0.03%]
降级选择性放疗的原则和范式：大胆迈向头颈部放射治疗的转折点
Amir H Safavi,Nancy Y Lee,C Jillian Tsai
Amir H Safavi
Fundamental axioms of elective nodal irradiation (ENI) for head and neck cancers merit re-examination in contemporary practice. Standard ENI doses to volumes bordering critical organs-at-risk increased during the transition from two-dimensi...
The Future of Head and Neck Radiotherapy: Not Your Father's Three-Field [0.03%]
头颈放射治疗的未来：不再是你父亲的三野时代
David J Sher,Yvonne M Mowery
David J Sher
The Role of Radiotherapy in Lymphoma Patients Undergoing CAR T Therapy: Past, Present, and Future [0.03%]
CAR-T治疗的淋巴瘤患者放疗的作用：过去、现在和未来展望
David G Wallington,Brandon S Imber,Michael Scordo et al.
David G Wallington et al.
Chimeric antigen receptor (CAR) T-cell receptor therapy has transformed outcomes for patients with relapsed and refractory diffuse large B-cell lymphoma (R/R DLBCL). It is currently approved in the third line for all patients and in the sec...
Radiation for Multiple Myeloma in the Era of Novel Agents: Indications, Safety, and Dose Selection [0.03%]
靶向药物时代多发性骨髓瘤放射治疗的指征、安全性及剂量选择
Samuel C Zhang,Leslie K Ballas
Samuel C Zhang
Survival outcomes for multiple myeloma (MM) have drastically improved over the past two decades with the advent of highly effective biologic agents and integration of autologous stem cell transplant (ASCT) for select patients. Despite these...
Radiation as an Immune Modulator: Where We Are With Modern Total Body Irradiation [0.03%]
辐射的免疫调节作用：现代全身照射的现状如何？
Eric Simiele,Savita Dandapani,Chunhui Han et al.
Eric Simiele et al.
Total body irradiation (TBI) has been an important component of myeloablative and nonmyeloablative conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT) for decades. Playing a dual role, both cytotoxic and immu...
Ritesh Kumar,Rahul R Parikh
Ritesh Kumar
Lymphoma in elderly patients has unique treatment challenges due to baseline co-morbidities, nutrition status, impairment in functional capacities and fitness. While geriatric-specific assessment can be used to tailor treatment decisions, l...
The Role of Radiotherapy in Hematologic Malignancies in Children, Adolescents, and Young Adults [0.03%]
儿童、青少年和年轻成人血液系统恶性肿瘤的放射治疗作用
Sarah A Milgrom,Andrea C Lo
Sarah A Milgrom
Hematologic cancers in pediatric, adolescent, and young adult populations include a diverse spectrum of malignancies. The cornerstone of treatment is multiagent chemotherapy. While radiation therapy (RT) is highly effective and played a piv...
Rising to the Top: How Immune-Checkpoint Inhibitors are Changing the Landscape of Treatment for Classic Hodgkin Lymphoma [0.03%]
免疫检查点抑制剂在经典型霍奇金淋巴瘤治疗中的崛起和发展
Ryan C Lynch,Michael Sargent Binkley
Ryan C Lynch
Immune checkpoint inhibitors have transformed the future management of classic Hodgkin lymphoma (CHL) in the frontline and salvage settings. Both nivolumab and pembrolizumab have high efficacy in CHL allowing for reduction of chemotherapy a...
Modern Treatment Delivery of Radiotherapy for Lymphomas and Leukemias: Making Every Gy Count [0.03%]
现代淋巴瘤和白血病放射治疗的实施：分秒必争，精益求精
Chirayu G Patel,Pierre Loap,Youlia M Kirova
Chirayu G Patel
Radiotherapy has a long history in the treatment of lymphoma and leukemia, in which late toxicity outcomes have motivated current goals to improve how radiotherapy is delivered. Contemporary advanced radiotherapy techniques, including inten...