CHEK2 Germline Variants and Their Clinical Implications: Experience from a Turkish Hereditary Cancer Cohort [0.03%]
土耳其遗传性癌症队列中CHEK2基因 germline变异及临床意义
Zehra Manav Yigit,Osman Semih Dikbas,Fatih Mergen et al.
Zehra Manav Yigit et al.
CHEK2 is a moderate-penetrance tumor suppressor gene primarily linked to hereditary breast cancer, yet growing evidence implicates it in a wider tumor spectrum. Data from underrepresented populations, such as Türkiye, remains limited. We r...
Post-Marketing Safety of Tazemetostat in Antitumor Therapy: A Real-World Pharmacovigilance Study of the FDA Adverse Event Reporting System [0.03%]
塔泽梅斯妥用于抗肿瘤治疗的上市后安全性：对美国食品药品管理局不良事件报告系统的药物流行病学研究
Chunyong Xia,Jie Liu,Lanxin Hu et al.
Chunyong Xia et al.
Background: Tazemetostat is an oral inhibitor of enhancer of zeste homolog 2 (EZH2) and is used for the treatment of epithelioid sarcoma (ES) and follicular lymphoma (FL). In this study, we investigated the adverse events...
Risk Factors and Epidemiological Trends (1990-2021) in Esophageal Cancer Across East and South Asia [0.03%]
1990年至2021年东亚和南亚食管癌的危险因素及流行病学趋势
Lovely Jain,Vikas Singh,Shalini Singla
Lovely Jain
Esophageal cancer remains a leading cause of cancer-related morbidity and mortality worldwide, with East and South Asia bearing a disproportionate burden. Despite global declines in age-standardized rates, these regions continue to face cha...
Expression of Transmembrane Glycoprotein TROP2 in Triple-Negative Breast Cancer and It's Potential as a Molecular Classifier for Targeted Therapy [0.03%]
乳腺三阴性癌中跨膜糖蛋白TROP2的表达及其分子分型和靶向治疗价值研究
Roshni Saravanan,Vaishnavi Balasubramanian,Srikanth Swamy Swaroop B et al.
Roshni Saravanan et al.
Trophoblast Cell-surface antigen 2 (TROP2), a calcium signal transducer & a transmembrane glycoprotein expression was studied in Triple-Negative Breast Cancer (TNBC) patients. mRNA expression, immunohistochemical and immunofluorescence anal...
Efficacy and Safety of Different Dosages of Anlotinib Combined with PD-1 Monoclonal Antibody in the Treatment of Advanced Non-Small Cell Lung Cancer [0.03%]
阿帕替尼联合PD-1单抗不同剂量治疗晚期非小细胞肺癌的疗效及安全性
Juan Jiang,Yin Xiao,Shixue Chen et al.
Juan Jiang et al.
Objective: This study investigates the efficacy and safety of anlotinib in combination with PD-1 monoclonal antibody across different dosing regimens for advanced non-small cell lung cancer (NSCLC). It aims to determine w...
Effect of Adjuvant Chemotherapy on Survival Among Patients with Stage IIA Colorectal Cancer Following Radical Surgery: A Propensity Score-Matching Study Using the SEER Database [0.03%]
术后辅助化疗对IIB期结直肠癌患者生存影响的倾向性匹配分析：基于SEER数据库的研究
Qilong Lan,Lanlan Xie,Dongbo Xu et al.
Qilong Lan et al.
To explore the effect of adjuvant chemotherapy on the overall survival (OS) and cancer cause-specific survival (CSS) in patients with AJCC stage IIA colorectal cancer. Date of patients with stage IIA colorectal cancer who underwent radical ...
Prognostic Model Based on NAD+ Metabolism-Related Genes Predicts Breast Cancer Outcomes and Guides Immunotherapy [0.03%]
基于NAD+代谢相关基因的预后模型预测乳腺癌结局和指导免疫治疗
Li Wang,Xi Mao,Jiaqi Ye et al.
Li Wang et al.
Background: Breast cancer (BCa) is a common malignant tumor in women, and the prognostic value of NAD+ metabolism-related genes (NMRGs) in BCa remains to be clarified. ...
Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study [0.03%]
新辅助放化疗后病理完全缓解的局部晚期直肠癌患者的长期肿瘤学结果：土耳其肿瘤学研究小组的一项研究
Mukremin Uysal,Sezer Saglam,İsmail Beypınar et al.
Mukremin Uysal et al.
The goal of this study was to look at the long-term survival outcomes and clinical characteristics of stage II/III locally advanced rectal cancer (LARC) patients who acquired pathological complete response (pCR) following neoadjuvant chemor...
Linking p53 rs1042522 Variant to Thyroid Cancer Risk: Insights from a Comprehensive Meta-Analysis of 2116 Cases [0.03%]
一项关于甲状腺癌的全面meta分析：p53基因多态性与甲状腺癌发病风险的相关性研究（2116事例）
Mohammad Vakili-Ojarood,Ahmad Shirinzadeh-Dastgiri,Mojtaba Meybodian et al.
Mohammad Vakili-Ojarood et al.
This meta-analysis investigates the association between the p53 rs1042522 polymorphism and thyroid cancer, analyzing 18 case-control studies with 2,116 cases and 4,017 controls. It finds that the C allele is linked to a higher cancer risk (...
The Neutrophil-to-Lymphocyte Ratio May be the Best Serological Biomarker in Predicting Longer Survival in Neoadjuvant Treatment of Triple-Negative Breast Cancer [0.03%]
预测新辅助治疗三阴性乳腺癌较长生存期的最佳血清生物标志物可能是中性粒细胞与淋巴细胞比率
Gábor Rubovszky,Norbert Mészáros,Zoltán Mátrai et al.
Gábor Rubovszky et al.
Recently some serologic parameters emerged as potential prognostic factors of triple-negative breast cancer (TNBC). We aimed to establish the most relevant factors and select optimal cutoff points for prospective investigations. Data from 1...