Cancer-Specific Changes in Diagnostic Activity During the COVID-19 Pandemic: An Analysis of Canadian CiNA Data [0.03%]
加拿大CiNA数据的COVID-19大流行期间癌症诊断的特殊变化分析
Omar Abdel-Rahman
Omar Abdel-Rahman
Objective: To analyze the patterns of change in diagnostic activity of different cancers before and after 2020, among Canadian jurisdictions covered in the CiNA dataset. ...
Circulating Tumor DNA in Tracking Minimal Residual Disease and Recurrence in Ovarian Cancer: A Retrospective Cohort [0.03%]
循环肿瘤DNA在追踪卵巢癌残留病灶和复发中的作用：一项回顾性队列研究
Fei Meng,Qingyang Liu,Chenchen Cheng et al.
Fei Meng et al.
Purpose: After radical treatment for ovarian cancer, the presence of minimal residual disease (MRD) remains a major obstacle to achieving cure. We explored the prognostic and translational value of MRD assessment by track...
Association of XPD Gene Polymorphisms with Cutaneous Melanoma Risk: A Meta-Analysis and Trial Sequence Evaluation [0.03%]
XPD基因多态性与皮肤黑色素瘤风险关联的meta分析及试验序列评价
Nazila Farnoush,Amirhossein Rahmani,Mehdi Khosravi-Mashizi et al.
Nazila Farnoush et al.
Background: Conflicting results have emerged regarding the relationship between XPD polymorphisms and cutaneous melanoma (CM) susceptibility. This meta-analysis aims to clarify this association. ...
Current Landscape of Anti-HER2 Targeted Therapy in Breast Cancer: Challenges and Future Perspectives [0.03%]
当前乳腺癌抗HER2靶向治疗现状、挑战及未来展望
Pooja Bharali,Vikrant Mehta,Subhash Chand et al.
Pooja Bharali et al.
HER2-positive breast cancer is an aggressive subtype effectively targeted by monoclonal antibodies such as trastuzumab and pertuzumab, along with ADCs, TKIs, and chemotherapy. Despite clinical success, challenges including therapeutic resis...
Andrezza Moraes Flórido,Catarina Clapis Zordão,Tamires Coelho de Almeida et al.
Andrezza Moraes Flórido et al.
Neoadjuvant chemotherapy is used as a treatment for breast cancer patients due to its potential to enable more conservative surgeries. Chemotherapeutic agents can produce side effects that result in functional impairments. The aim of this s...
The Effect of Group Counselling on Body Image and Sexual Satisfaction Among Women with Breast Cancer: A Randomized Clinical Trial [0.03%]
团体咨询对乳腺癌女性患者身体意象和性满足感影响的随机临床试验
Fatemeh Vakili,Talat Khadivzadeh,Mohsen Asgharinekah et al.
Fatemeh Vakili et al.
Objective: Group counselling (GC) can help people to cope with cancer-induced bodily changes. However, group counselling effects on sexual health of breast cancer patients is largely unknown. The present study aimed at in...
Prognostic Impact of TP53 and RB1 Alterations in Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel [0.03%]
TP53和RB1改变对多西他赛治疗转移性去势抵抗性前列腺癌预后影响的作用
Ja Yoon Heo,Chung Lee,Heesun Shin et al.
Ja Yoon Heo et al.
Background: Docetaxel remains a standard treatment for metastatic castration-resistant prostate cancer (mCRPC), yet reliable prognostic markers are lacking. TP53 and RB1, key tumor suppressor genes regulating cell-cycle c...
Biomarkers for Prognosis in Osteosarcoma: From Molecular Signatures to Clinical Applications [0.03%]
骨肉瘤预后的生物标志物：从分子特征到临床应用
Elias Abboud,Guy Awad,Marc Boutros et al.
Elias Abboud et al.
Osteosarcoma is an aggressive malignancy with a 5-year survival below 30% in metastatic disease, highlighting the need for prognostic tools. A review of 93 studies identified consistent prognostic biomarkers. p53 overexpression was associat...
Treatment Strategies for Biliary Tract Cancer: A Surgical Perspective from Historical Evolution to Neoadjuvant Therapy [0.03%]
从历史演变至新辅助治疗的胆道癌外科治疗策略的观点分析
Takehiro Okabayashi,Motoyasu Tabuchi,Teppei Tokumaru et al.
Takehiro Okabayashi et al.
Background: Biliary tract cancer (BTC) is an aggressive malignancy with poor prognosis despite curative resection, necessitating multidisciplinary treatment strategies beyond surgery alone. ...
Next-Generation Therapies for Meningioma: Overcoming Barriers and Expanding Treatment Options [0.03%]
脑膜瘤下一代疗法：克服障碍和扩大治疗选择
Shayan Sheikhmiri,Elyas Hasanzadeh,Reza Chaman et al.
Shayan Sheikhmiri et al.
Meningioma is the most common primary brain tumor. Surgical resection and, in some cases, adjuvant radiotherapy remain the cornerstone of treatment, offering an exceptionally high cure rate. However, treatment can be challenging, particular...