Concomitant radiation therapy and trastuzumab deruxtecan in metastatic breast cancer: feasibility, safety, and outcomes from a real-life multicentre international cohort [0.03%]
同时放疗和曲妥珠单抗deruxtecan治疗转移性乳腺癌：来自真实世界多中心国际队列的可行性和安全性及疗效分析
Luca Visani,Ivica Ratosa,Rupert Bartsch et al.
Luca Visani et al.
Background and purpose: Radiation therapy (RT) remains a cornerstone of management for metastatic breast cancer (mBC), though systemic therapy drives overall disease control. Administering RT concomitantly with systemic t...
Age-stratified toxicity patterns of CDK4/6 inhibitors in older women with breast cancer: Disproportionality analysis from the FAERS database [0.03%]
来自治疗不良事件报告系统数据库的 disproportionality 分析：老年乳腺癌患者中 CDK4/6 抑制剂的年龄分层毒性反应模式
Bahadır Köylü,Buğra Han Esen,Cevat İlteriş Kıkılı et al.
Bahadır Köylü et al.
Background: Despite their benefits, the safety of cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors in older patients remains underexplored. We aimed to investigate the toxicities associated with CDK4/6 inhibitors in s...
Baseline systemic inflammatory indices predict late radiation-induced fibrosis and toxicity in patients with early breast cancer [0.03%]
基线全身性炎症指标可预测早期乳腺癌患者晚期放射诱导的纤维化和毒性反应
Lorenzo Vinante,Jerry Polesel,Andrea Sacilotto et al.
Lorenzo Vinante et al.
Radiation therapy (RT) is a standard component of treatment for early breast cancer and ductal carcinoma in situ. Although survival is excellent, RT-related side effects can impair long-term quality of life. We aimed to develop models to pr...
How should we manage abemaciclib in the peri-operative period during secondary breast reconstruction: balancing oncologic benefit and surgical safety [0.03%]
围手术期帕博西尼用于二次乳房重建的管理：如何平衡肿瘤学效益和外科安全性
Michel Gabriel Cazenave,Leslie Elahi,Katia Mahiou et al.
Michel Gabriel Cazenave et al.
Abemaciclib, a CDK4/6 inhibitor, has emerged as a pivotal therapy in hormone receptor-positive, HER2-negative breast cancer, including in the adjuvant setting for high-risk early disease. Its integration into long-term oncologic strategies ...
Multidisciplinary meeting for breast cancer care: EUSOMA recommendations for optimization [0.03%]
乳腺癌多学科诊疗会议：EUSOMA优化建议
G Curigliano,L Marotti,C Barrios et al.
G Curigliano et al.
Introduction: In breast cancer care multidisciplinary meetings (MDMs) are fundamental. Recently, the increasing number of patients, the complexity of cancer treatments, the shortages of specialists, and constrained hospit...
Korean nationwide analysis of male breast Cancer: Incidence trends, treatment disparities, and survival compared with female patients [0.03%]
韩国全国男性乳腺癌分析：发病率趋势、治疗差异和与女性患者的生存率比较
Jiyeong Kim,Shin Jeong Pak,Min Sung Chung et al.
Jiyeong Kim et al.
Background: s: Male breast cancer (MBC) accounts for less than 1 % of all breast cancer cases and is considered a rare disease. However, its incidence is steadily increasing. Despite this trend, comprehensive analyses com...
HER2/CEP17 ratio is associated with pCR after HER2-directed neoadjuvant treatment in the phase III NeoALTTO trial [0.03%]
针对HER2的术前新辅助治疗后，HER2/CEP17比率与NeoALTTO三期临床试验中pCR的关系
Christian F Singer,Franz Koenig,Stephanie Kacerovsky-Strobl et al.
Christian F Singer et al.
Purpose: In early breast cancer, HER2-directed therapies are approved for the treatment of patients with HER2-positive invasive breast cancer as defined by HER2 protein overexpression, or HER2 gene amplification with HER2...
A prognostic gene model with psychological stress-related genes captures immune activation in breast cancer [0.03%]
一个与心理压力相关的预后基因模型能够捕捉乳腺癌中的免疫活化现象
Tian Du,Jiayi Tang,Hanqi Zhang et al.
Tian Du et al.
Background: Chronic stress and depression play critical roles in modulating breast cancer oncogenesis. Psychological stress-related genes can regulate tumor behavior and serve as prognostic factors. Here, we constructed a...
Divergence of DNA tumor mutations in cerebrospinal fluid in metastatic breast cancer patients with leptomeningeal metastases [0.03%]
转移性乳腺癌患者脑膜转移瘤中脑脊液肿瘤DNA突变的差异性分析
Peter H Wessels,Sten Cornellisen,Kim Monkhorst et al.
Peter H Wessels et al.
Purpose: To study differences in genetic alterations between primary breast cancer, systemic metastases, and cerebrospinal fluid (CSF) in patients with leptomeningeal metastases (LM). ...