Oxidative stress-driven dysregulation of the MMP-2/TIMP-2 axis in chronic obstructive pulmonary disease: Molecular mechanisms, genetic polymorphisms, and therapeutic implications [0.03%]
慢性阻塞性肺疾病中氧化应激驱动的MMP-2/TIMP-2轴失调：分子机制、遗传多态性及治疗意义
Poonam Sangwan,Jai Gopal Sharma,Md Anwar Habib et al.
Poonam Sangwan et al.
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disorder characterized by persistent airflow limitation, airway remodeling, and irreversible destruction of alveolar structures. Increasing evidence suggests th...
The disease burden of ILD at the global, regional, and national levels from 1990 to 2021, and projections until 2035: Findings from the 2021 global burden of disease study with focus on China [0.03%]
基于全球疾病负担研究的间质性肺病1990至2021年全球、国家和区域疾病负担及2035年前预测：以中国为重点地区的分析
Wei Zhang,Weiwei Chen,Qian Zhang
Wei Zhang
Objectives: Interstitial lung disease (ILD) and pulmonary sarcoidosis are chronic respiratory conditions characterized by progressive inflammation and fibrosis, contributing to significant global health challenges. Unders...
Targeting chronic mucus hypersecretion in respiratory diseases - focus on OPEP devices [0.03%]
针对呼吸系统疾病中慢性痰多症状的治疗——聚焦气道廓清装置(OPEP)
Rajesh Venkitakrishnan,Agam Vora,P K Thomas et al.
Rajesh Venkitakrishnan et al.
Chronic respiratory diseases pose an ever-increasing health burden in India. Chronic mucus hypersecretion (CMH) is a hallmark feature of many chronic obstructive respiratory diseases (CRDs). CMH is associated with impaired mucociliary clear...
Classification of patient-ventilator asynchronies, development of an updated conceptual framework: Scoping review [0.03%]
患者与呼吸机不同步的分类及更新概念框架的发展：综述型研究
Michel Perez-Garzon,Henry Robayo-Amortegui,Jaime Fernandez-Sarmiento et al.
Michel Perez-Garzon et al.
Purpose: Patient-ventilator asynchrony (PVA), a mismatch between a patient's respiratory effort and the ventilator's support, affects up to 85% of patients receiving invasive mechanical ventilation (IMV). It is associated...
Comparison of GLI-Global and PLATINO spirometry equations for disease identification and staging in a Mexican-Hispanic population [0.03%]
GLI全球方程和PLATINO方程在墨西哥裔美国人肺功能识别和分级中的比较研究
Arturo Cortes-Telles,Michele R Schaeffer,Esperanza Figueroa-Hurtado et al.
Arturo Cortes-Telles et al.
Background: The Global Lung Function Initiative updated spirometry reference equations (GLI-Global) to be race-neutral. However, concerns remain that GLI-Global may shift predicted values in underrepresented populations. ...
The impact of benralizumab and dupilumab on exhaled volatile organic compound profiles of severe asthma patients - a preliminary analysis [0.03%]
关于抗I型干扰素药物治疗SLE的研究进展及面临的挑战
S M Vassileva,S Shahbazi Khamas,N Dyhre-Petersen et al.
S M Vassileva et al.
Volatile organic compounds (VOCs) in exhaled breath reflect biological processes in the lungs. Exploring VOC profiles in severe asthma patients starting biologics may reveal treatment-related biological changes over time. This study aimed t...
Viewpoint: Pathway-Sensitive Eligibility for Biologic Therapy in COPD: The Role of Primary Care, Phenotyping, and Eosinophil-Guided Management [0.03%]
观点文章：COPD生物制剂治疗的途径敏感性准入标准：全科医生的作用、表型和以嗜酸性粒细胞为指导的管理策略
Konstantinos Bartziokas,Constantinos Glynos,Andriana I Papaioannou
Konstantinos Bartziokas
There is currently increasing interest in the heterogeneity of airway inflammation in COPD, to implement precision medicine that individualizes treatment based on clinical and biological characteristics. The recognition of T2 inflammation i...
Clinical characteristics and outcomes of people with cystic fibrosis with homozygous minimal function genotypes compared to those with F508del/minimal function genotypes [0.03%]
同工型最小功能基因型和F508del/最小功能基因型囊性纤维化患者的临床特征及预后情况的比较分析
Michael W Konstan,Brandon Lumsden,Prema Menon et al.
Michael W Konstan et al.
This observational, retrospective study compared clinical characteristics and outcomes in people with cystic fibrosis (pwCF) homozygous for minimal function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (M...
Validation of claims-based algorithms for identifying selected interstitial lung disease (idiopathic interstitial pneumonias and drug-induced interstitial lung disease) [0.03%]
基于理赔数据的算法验证在选定间质性肺疾病（特发性间质性肺炎和药物诱发性间质性肺疾病）中的应用
Kensuke Kataoka,Soko Setoguchi,Naoki Nakashima et al.
Kensuke Kataoka et al.
Background: Interstitial lung disease (ILD) is a heterogeneous group of more than 200 diseases that cause fibrosis or inflammation of the pulmonary parenchyma. ILD is a leading cause of death, yet data on its precise inci...
Lung Function after Randomization to Metformin, Lifestyle Intervention or Placebo in the Diabetes Prevention Program Outcomes Study (DPPOS) [0.03%]
糖尿病预防计划结局研究（DPPOS）中随机给予二甲双胍、生活干预或安慰剂后的肺功能变化
Carrie L Pistenmaa,Lindsay Doherty,Emilia A Hermann et al.
Carrie L Pistenmaa et al.
Introduction: Metformin and physical activity have been suggested as beneficial for chronic lung disease; however, there are no prior randomized trials. M...