Unmasking the Genetic Heterogeneity of Cystic Fibrosis in the Torbat Jam Region: From Common Variants to Large Deletions and the Challenge of Missing Heritability [0.03%]
揭开托尔巴特贾姆地区囊性纤维化遗传异质性的面纱：从常见变异到大片段缺失以及遗漏遗传率的挑战
Haleh Ghaneinejad,Hossein Dinparast,Saeideh Tavakoli et al.
Haleh Ghaneinejad et al.
Background: Cystic Fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CFTR gene. The genetic spectrum of CF in Iran is highly heterogeneous due to ethnic diversity and consanguinity, particularly ...
Bridging the global survival gap in cystic fibrosis: Evidence from a 30-year longitudinal Mexican cohort [0.03%]
桥接囊性纤维化全球生存差异：来自墨西哥纵向队列的证据
Magali Reyes-Apodaca,Rodrigo Vázquez-Frias,Isela Núñez-Barrera et al.
Magali Reyes-Apodaca et al.
Background: Survival in cystic fibrosis (CF) has improved markedly in high-income countries over recent decades; however, important disparities persist across regions. Long-term data describing survival patterns and their...
People with Cystic Fibrosis' Experience of Symptom Burden While Taking Elexacaftor/ Tezacaftor/ Ivacaftor [0.03%]
囊性纤维化患者使用Elexacaftor/Tezacaftor/Ivacaftor治疗期间症状负担体验
Emily F Muther,Sidney L Gibson,Christine Ford et al.
Emily F Muther et al.
Background: Despite improvements seen with elexacaftor/tezacaftor/ivacaftor (ETI), many people with CF (PWCF) still experience symptom burden. This study aimed to evaluate current perceived symptom burden and contrast it ...
Sonographic pleural line excursion in children with bronchospasm: a prospective single-center study [0.03%]
儿童支气管痉挛的超声胸膜线移动度变化：一项单中心前瞻性研究
Eric Scheier,Khalil AbuKishk
Eric Scheier
Pediatric asthma scoring relies on subjective findings with poor interrater reliability. We prospectively studied children presenting to a pediatric emergency department with acute wheeze requiring beta-agonist therapy, measuring pleural li...
Mucus plugs in COPD and cardiovascular mortality: An emerging risk pathway and the therapeutic potential of mucolytic strategies [0.03%]
慢性阻塞性肺疾病中的粘液栓与心血管死亡风险：一种新兴的风险途径及溶解粘液的潜在治疗策略
Mario Cazzola,Luigino Calzetta,Vincenzo Parente et al.
Mario Cazzola et al.
Airway mucus plugging is an underrecognized feature of COPD that is increasingly associated with adverse outcomes, including higher mortality rates. Computed tomography studies demonstrate that mucus plugs are prevalent, variable, and frequ...
Hyun Woo Lee,Sang Hyuk Kim,Chin Kook Rhee et al.
Hyun Woo Lee et al.
Background: Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently coexist and share common risk factors. However, the mortality burden associated with their co-occurrence has not been fu...
Acute COPD Exacerbation and long-term cardiopulmonary outcomes: Real-world EXACOS-CP evidence study in Israel [0.03%]
急性COPD加重与长期的心肺结局相关性：以色列EXACOS-CP真实世界证据研究
Samah Hayek,Uri Gottlieb,Nir Treves et al.
Samah Hayek et al.
Background: Chronic obstructive pulmonary disease (COPD) is a common and debilitating respiratory disease. Acute exacerbations of COPD (AECOPD), characterized by a sudden worsening of symptoms, are associated with cardiov...
Association between corticosteroid therapy during acute COVID-19 and Long COVID symptoms: a propensity score overlap-weighted analysis [0.03%]
糖皮质激素治疗与长期新冠肺炎症状的关联：倾向性评分重叠加权分析
Naoki Fukunaga,Takanori Asakura,Hideki Terai et al.
Naoki Fukunaga et al.
Background: The association between acute-phase corticosteroid therapy and subsequent Long COVID symptoms remains uncertain. Therefore, we aimed to evaluate the association between systemic corticosteroid therapy during h...
The co-existence of asthma and neurodevelopmental or mental health disorders and its association with health-related outcomes in a national sample of Canadian children [0.03%]
儿童哮喘与神经发育或精神疾病共病及其对健康结果的影响：基于加拿大全国样本的调查
Joshua A Lawson,Minyoung Kim,Parisa Jandaghi et al.
Joshua A Lawson et al.
Background: Asthma and neurodevelopmental and mental disorders (NMD) are associated. It is important to understand how having both asthma and a NMD is associated with health outcomes. We sought to determine if having both...
Guidance for chest-CT in children and adults with cystic fibrosis: A European perspective (part 2: special situations/respiratory complications) [0.03%]
囊性纤维化患者胸部CT检查指南（下篇：特殊情况/呼吸系统并发症）
Michael Fayon,Kate Hill,Luca Riberi et al.
Michael Fayon et al.
This manuscript covers guidance proposed by The European Cystic Fibrosis Society Clinical Trials Network (ECFS-CTN) for the use of chest computed tomography (CT) scans in special situations such as haemoptysis, aspergillus-related lung dise...