VPAC1 receptor binding site: contribution of photoaffinity labeling approach [0.03%]
光亲和标记法对VPAC1受体结合位点的贡献
A Couvineau,E Ceraudo,Y-V Tan et al.
A Couvineau et al.
The vasoactive intestinal peptide (VIP) is a prominent 28 aminoacid neuropeptide with wide distribution in both central and peripheral nervous systems, where it plays important regulatory role in many physiological processes. VIP has a larg...
Ethanol exposure selectively alters beta-endorphin content but not [3H]-DAMGO binding in discrete regions of the rat brain [0.03%]
乙醇暴露可选择性地改变大鼠脑内特定区域的β-内啡肽含量但不影响[3H]-DAMGO结合力
M Leriche,M Méndez
M Leriche
The dopaminergic mesocorticolimbic system plays an important role in the reinforcing effects of ethanol. Opioid peptides modulate the activity of this system and have been suggested to mediate, at least in part, the reinforcing properties o...
Genome-wide census and expression profiling of chicken neuropeptide and prohormone convertase genes [0.03%]
鸡神经肽和蛋白激素转换酶基因的全基因组普查及表达谱分析
K R Delfino,B R Southey,J V Sweedler et al.
K R Delfino et al.
Neuropeptides regulate cell-cell signaling and influence many biological processes in vertebrates, including development, growth, and reproduction. The complex processing of neuropeptides from prohormone proteins by prohormone convertases, ...
Structural analysis of three peptides related to the transmambranic helix VI of AT1 receptor [0.03%]
与血管紧张素Ⅱ受体AT1跨膜螺旋VI相关的3个肽的结构分析研究
Samuel Marcos Ribeiro de Noronha,Silvana Aparecida Alves Corrêa,Erick Fernando Poletti et al.
Samuel Marcos Ribeiro de Noronha et al.
Introduction: Angiotensin II (AII) is the main active product of the renin angiotensin system. Better known effects of AII are via AT1 receptor (AT1R). Expression of AT1R mutants (L265D and L262D) in CHO cells increased c...
Differential effect of prolonged food restriction and fasting on hypothalamic malonyl-CoA concentration and expression of orexigenic and anorexigenic neuropeptides genes in rats [0.03%]
长期限食与饥饿对大鼠下丘脑丙二酰辅酶a浓度以及摄食肽基因表达的不同时相变化的影响
Elzbieta Sucajtys-Szulc,Jacek Turyn,Elzbieta Goyke et al.
Elzbieta Sucajtys-Szulc et al.
Several lines of evidence suggest that malonyl-CoA in the hypothalamus plays an important role in monitoring and modulating body energy balance. In fasted state the level of malonyl-CoA concentration significantly decreases. Simultaneously,...
Endomorphin-suppressed nitric oxide release from mice peritoneal macrophages [0.03%]
内啡肽抑制小鼠腹腔巨噬细胞释放一氧化氮
Tihomir Balog,Ana Sarić,Sandra Sobocanec et al.
Tihomir Balog et al.
Endomorphins are newly discovered mu-opioid receptor selective immunocompetent opioid peptides. Endomorphin 1 is predominantly distributed in brain, while endomorphin 2 is widely allocated in the spinal cord. Lately, endomorphins have been ...
Bradykinin B(1) receptor antagonist R954 inhibits eosinophil activation/proliferation/migration and increases TGF-beta and VEGF in a murine model of asthma [0.03%]
白三烯B1受体拮抗剂R954抑制小鼠哮喘模型中的嗜酸性细胞活化/增殖/迁移并增加TGF-β和VEGF的产生
Luciana M C Vasquez-Pinto,François Nantel,Pierre Sirois et al.
Luciana M C Vasquez-Pinto et al.
In the present study the effects of bradykinin receptor antagonists were investigated in a murine model of asthma using BALB/c mice immunized with ovalbumin/alum and challenged twice with aerosolized ovalbumin. Twenty four hours later eosin...
Fumiko Takenoya,Michiko Yagi,Haruaki Kageyama et al.
Fumiko Takenoya et al.
Neuropeptide W (NPW), which was recently isolated from the porcine hypothalamus, has been identified as the endogenous ligand of the orphan G protein-coupled receptors GPR7 (NPBWR1) and GPR8 (NPBWR2). Infusion of NPW increases food intake i...
Participation of kinin receptors on memory impairment after chronic infusion of human amyloid-beta 1-40 peptide in mice [0.03%]
人源β淀粉样蛋白1-40慢性输注小鼠后kinin受体参与病理损害的记忆障碍的作用及机制研究
Fabio Agostini Amaral,Mayra Tolentino Resk Lemos,Karis Ester Dong et al.
Fabio Agostini Amaral et al.
Chronic infusion of human amyloid-beta 1-40 (Abeta) in the lateral ventricle (LV) of rats is associated with memory impairment and increase of kinin receptors in cortical and hippocampal areas. Deletion of kinin B1 or B2 receptors abolished...
Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat [0.03%]
大鼠瞬时受体电位通道TRPV1、TRPA1和TRPM8对物质P或血清素的反应不同
Rumi Naono-Nakayama,Natsuki Sunakawa,Tetsuya Ikeda et al.
Rumi Naono-Nakayama et al.
Two tachykinin peptides, substance P (SP) and hemokinin-1 (HK-1), and three transient receptor potential (TRP) channels, TRPV1, TRPA1 and TRPM8, are similarly localized in the spinal dorsal horn and dorsal root ganglion, suggesting that TRP...