Contribution of the central dopaminergic system in the anti-hypertensive effect of kinin B1 receptor antagonists in two rat models of hypertension [0.03%]
中央多巴胺能系统在两种高血压大鼠模型中的激肽B1受体拮抗剂降压效应中的作用贡献
H De Brito Gariepy,P Carayon,B Ferrari et al.
H De Brito Gariepy et al.
Kinins are neuroactive peptides that could play a role in central autonomic control of blood pressure. Whereas kinin B1R binding sites were increased in specific brain areas of spontaneously hypertensive rats (SHR) and Angiotensin II (AngII...
Akt pathway activation and increased neuropeptide Y mRNA expression in the rat hippocampus: implications for seizure blockade [0.03%]
大鼠海马中Akt通路的激活和神经肽Y信使核糖核酸表达增加：对癫痫阻断的意义
Eduardo M Goto,Marcelo de Paula Silva,Sandra R Perosa et al.
Eduardo M Goto et al.
The aim of this study was to analyze the expression of survival-related molecules such Akt and integrin-linked kinase (ILK) to evaluate Akt pathway activation in epileptogenesis process. Furthermore, was also investigated the mRNA expressio...
Plasma Kallikrein and Angiotensin I-converting enzyme N- and C-terminal domain activities are modulated by the insertion/deletion polymorphism [0.03%]
插入/删除多态性通过调节血浆激肽原酶及血管紧张素转换酶N/C末端结构域活性影响心血管疾病风险
S S Almeida,C C Barros,M R Moraes et al.
S S Almeida et al.
Angiotensin I-converting enzyme (ACE) is recognized as one of the main effector molecules involved in blood pressure regulation. In the last few years some polymorphisms of ACE such as the insertion/deletion (I/D) polymorphism have been des...
Role of kinin B1 and B2 receptors in memory consolidation during the aging process of mice [0.03%]
激肽B1和B2受体在小鼠衰老过程中记忆巩固中的作用
Mayra Tolentino Resk Lemos,Fabio Agostini Amaral,Karis Ester Dong et al.
Mayra Tolentino Resk Lemos et al.
Under physiological conditions, elderly people present memory deficit associated with neuronal loss. This pattern is also associated with Alzheimer's disease but, in this case, in a dramatically intensified level. Kinin receptors have been ...
Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors [0.03%]
激肽B1和B2受体对诱导型一氧化氮合酶和内皮型一氧化氮合酶的不同调节作用
F Kuhr,J Lowry,Y Zhang et al.
F Kuhr et al.
Kinins are vasoactive peptides that play important roles in cardiovascular homeostasis, pain and inflammation. After release from their precursor kininogens, kinins or their C-terminal des-Arg metabolites activate two distinct G protein-cou...
Distribution and expression of B2-kinin receptor on human leukocyte subsets in young adults and elderly using flow cytometry [0.03%]
流式细胞仪检测青壮年和老年人外周血各亚群白细胞B2血管紧张素受体分布及表达
Benoit Bourdet,Christiane Pécher,Vincent Minville et al.
Benoit Bourdet et al.
The kallikrein-kinin system has been investigated in many experimental models. Dysregulations of the KKS are likely to be involved in pathologies such as inflammation, cancer and cardiovascular diseases. Previous works on the human KKS most...
Effect of kinin B2 receptor ablation on skeletal muscle development and myostatin gene expression [0.03%]
补体B2受体缺乏对肌营养不良和肌肉生长抑素基因表达的影响
K de Picoli Souza,E C Batista,E D Silva et al.
K de Picoli Souza et al.
Bradykinin (BK) is an active peptide that binds to the kinin B(2) receptor and induces biological events during the development and adult life. In this study we aimed to investigate the effect of kinin B(2) receptor ablation in the postnata...
Modulation of feeding and locomotion through mu and delta opioid receptor signaling in the nucleus accumbens [0.03%]
阿黑皮质核中μ和δ型鸦片受体的信号传导对进食和运动的调节作用
Yoshihiro Katsuura,Sharif A Taha
Yoshihiro Katsuura
Opioid signaling has been strongly implicated in driving palatable food consumption. The nucleus accumbens (NAcc) is one important site of this effect; hyperphagia elicited by administration of exogenous mu opioid receptor (MOR) ligands in ...
Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding [0.03%]
下丘脑通过生长激素分泌促进剂调节进食的神经环路
Haruaki Kageyama,Fumiko Takenoya,Kanako Shiba et al.
Haruaki Kageyama et al.
Ghrelin, an n-octanoylated 28-amino acid brain-gut peptide, was first isolated from extracts of porcine stomach. Ghrelin is an endogenous ligand for the growth hormone secretagogue type 1a receptor (GHS-R1a), the functionally active form of...
Kinins in cardiac inflammation and regeneration: insights from ischemic and diabetic cardiomyopathy [0.03%]
激肽在心脏炎症和再生中的作用：来自缺血性和糖尿病性心肌病的启示
Konstantinos Savvatis,Dirk Westermann,Heinz-Peter Schultheiss et al.
Konstantinos Savvatis et al.
The kallikrein-kinin system (KKS) is a system of vasoactive peptides, the kinins, involved in different aspects of remodeling, inflammation and angiogenesis. Kinins mediate their actions through two receptors, B1R and B2R. It is increasingl...