Influence of tachykinin NK2 receptors on intestinal sensitivity and motility in newborn rats [0.03%]
大鼠速激肽NK2受体对肠道敏感性和运动的影响研究
M Tramontana,S Evangelista,S Giuliani et al.
M Tramontana et al.
The effect of tachykinin neurokinin NK(2) receptors activation on intestinal propulsion and colorectal sensitivity was studied in 7-15 days old newborn rats. In a first set of experiments investigating the intestinal transit, the selective ...
Central litorin injection is associated with primary anorexigenic effects that coincide with activation of the magnocellular division of the paraventricular nucleus [0.03%]
中心给药的利特灵与主要的食欲抑制作用有关，这与视上核巨细胞区的激活同时出现
Mark A Cline,Stuart A Cofield,Tetsuya Tachibana
Mark A Cline
The central mechanism that mediates litorin-induced satiety is poorly understood, and has not been studied in a non-mammalian species. Therefore, the aim of this study was to determine if litorin-induced satiety in an alternative vertebrate...
Wake promoting effects of cocaine and amphetamine-regulated transcript (CART) [0.03%]
柯克调节 transcript(CART)的促觉醒作用
Glenda L Keating,Michael J Kuhar,Donald L Bliwise et al.
Glenda L Keating et al.
Cocaine- and amphetamine-regulated transcript (CART) peptides modulate anxiety, food intake, endocrine function, and mesolimbic dopamine related reward and reinforcement. Each of these disparate behaviors takes place during the state of wak...
Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways [0.03%]
Y4受体和胰腺多肽通过下丘脑食欲素和神经营养因子依赖性通路调节摄食量
Amanda Sainsbury,Yan-Chuan Shi,Lei Zhang et al.
Amanda Sainsbury et al.
Gut-derived peptides are known to regulate food intake by activating specific receptors in the brain, but the target nuclei and neurons influenced are largely unknown. Here we show that peripherally administered pancreatic polypeptide (PP) ...
Correlations between angiotensinase activity asymmetries in the brain and paw preference in rats [0.03%]
关于大脑血管紧张素酶活性不对称性与大鼠爪偏好的相关性研究
He-ming Wu,Chao Wang,Xue-lian Wang et al.
He-ming Wu et al.
The function of angiotensin peptides is dependent upon the action of several aminopeptidases (APs) termed angiotensinases. Soluble (SOL) and membrane (MEM)-bound alanyl-AP (AlaAP) and cystinyl-AP (CysAP) are involved in the metabolism of an...
Acoustic startle response and sensorimotor gating in a genetic mouse model for the Y1 receptor [0.03%]
听觉惊跳反射和感觉运动门控在Y1受体基因型小鼠中的研究
T Karl,R Chesworth,L Duffy et al.
T Karl et al.
Recent research has highlighted a potential role for neuropeptide Y (NPY) and its Y(1) receptor in the development of schizophrenia. Genetic as well as molecular biological studies have demonstrated reduced levels of NPY in schizophrenia pa...
Compensatory mechanisms to maintain blood pressure in paraplegic rats: implication of central tachykinin NK-1 and NK-3 receptors? [0.03%]
脊髓损伤大鼠维持血压的代偿机制及其中枢速激肽NK-1和NK-3受体的作用？
Frank Cloutier,Jenny L Lauschke,Pascal Carrive
Frank Cloutier
People with high level spinal cord injury (SCI) suffer from both hypotension and spontaneous hypertension due to loss of supraspinal control of spinal sympathetic outflow. Few reports have addressed whether any changes occur in central regu...
Brett Alldredge
Brett Alldredge
Anxiety and depression are highly prevalent disorders of mood posing significant challenges to individuals and society. Current evidence indicates no single neurobiological determinant underpins these conditions and an integrated approach i...
Antidiabetic efficacy of bradykinin antagonist R-954 on glucose tolerance test in diabetic type 1 mice [0.03%]
血管紧张素拮抗剂R-954改善1型糖尿病小鼠糖耐量的作用研究
Orlando L Catanzaro,Damian Dziubecki,Pablo Obregon et al.
Orlando L Catanzaro et al.
Insulin-dependent diabetes mellitus (type 1 diabetes) is an inflammatory autoimmune disease associated with many complications including nephropathy, retinopathy, neuropathy and hyperalgesia. Experimental evidence has shown that the bradyki...
Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe(8)psi(CH(2)NH)Arg(9)]-BK in a F98 glioma rat model: an MRI study [0.03%]
选择性地用激肽B2受体激动剂[Few(8)psi(CH(2)NH)Arg(9)]-BK开启F98胶质瘤大鼠模型的肿瘤血脑屏障：磁共振成像研究
Jérôme Côté,Martin Savard,Veronica Bovenzi et al.
Jérôme Côté et al.
Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain barrier (BBB). One approach for transporting drugs across the BBB involves the activation of bradykinin-B2 receptors...