CRF2 null mutation increases sensitivity to isolation rearing effects on locomotor activity in mice [0.03%]
CRF2基因突变增加小鼠因隔离喂养导致运动行为改变的敏感性
Jodi Gresack,Susan Powell,Mark Geyer et al.
Jodi Gresack et al.
Background: Developmental stressors are consistently reported to increase risk for certain neuropsychiatric disorders including schizophrenia, depression, and post-traumatic stress disorder. Recent clinical evidence suppo...
Alarin stimulates food intake in male rats and LH secretion in castrated male rats [0.03%]
阿尔林刺激雄性大鼠摄食和去势雄性大鼠LH分泌
Nicole Van Der Kolk,Farrah N Madison,Margaret Mohr et al.
Nicole Van Der Kolk et al.
Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently ala...
Alma Sanchez,Suchin Wadhwani,Paula Grammas
Alma Sanchez
A large literature demonstrates the multifunctional nature of vascular endothelial growth factor (VEGF). Though initially characterized as an endothelial cell-specific factor, recent studies reveal that VEGF has numerous effects on diverse ...
E Pétervári,A Garami,S Soós et al.
E Pétervári et al.
Long-term regulation of energy balance involves two major trends: first age-related obesity develops in the middle-aged, later it is followed by anorexia of aging (sarcopenia and/or cachexia). A dynamic balance between orexigenic and anorex...
Abeta20-29 peptide blocking apoE/Abeta interaction reduces full-length Abeta42/40 fibril formation and cytotoxicity in vitro [0.03%]
阿贝塔20-29肽通过阻断载脂蛋白E/阿贝塔相互作用减少体外全长阿贝塔42/40纤维形成和细胞毒性
Jian Hao,Wei Zhang,Peng Zhang et al.
Jian Hao et al.
A key event in the pathogenesis of Alzheimer's disease (AD) is the conversion of the peptide beta-amyloid (Abeta) from its soluble monomeric form into various aggregated morphologies in the brain. Apolipoprotein E (apoE) is known to act as ...
Changes in the gene expression of specific G-protein subunits correlate with morphine insensitivity in streptozotocin-induced diabetic rats [0.03%]
链脲佐菌素诱导的糖尿病大鼠中特定G蛋白亚基基因表达的变化与阿片耐受性相关
Zahra Hajializadeh,Saeed Esmaeili-Mahani,Vahid Sheibani et al.
Zahra Hajializadeh et al.
Several animal and human studies have shown a decreased analgesic potency of morphine in diabetic subjects. Since G-protein subunits have an important role in morphine effects at the cellular level and the exact mechanism(s) of diabetes-ind...
Effect of genetic deletion of the vanilloid receptor TRPV1 on the expression of Substance P in sensory neurons of mice with adjuvant-induced arthritis [0.03%]
遗传剔除vanilloid受体TRPV1对完全弗氏佐剂诱导的小鼠类风湿关节炎感觉神经元中SP表达的影响
Helen H Willcockson,Yong Chen,Ji Eun Han et al.
Helen H Willcockson et al.
The neuropeptide Substance P (SP), expressed by nociceptive sensory afferents in joints, plays an important role in the pathogenesis of arthritis. Capsaicin causes neurons in the dorsal root ganglia (DRG) to release SP from their central an...
Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat [0.03%]
脑室内注射人GLP-1对大鼠焦虑及胆碱酶诱导的癫痫发作的影响研究
Guldal Gulec,Naciye Isbil-Buyukcoskun,Nevzat Kahveci
Guldal Gulec
Glucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to i...
Suppressive effects by cysteine protease inhibitors on naloxone-precipitated withdrawal jumping in morphine-dependent mice [0.03%]
半胱氨酸蛋白酶抑制剂对吗啡依赖小鼠纳洛酮戒断跳跃反应的抑制作用
Koichi Tan-No,Tasuku Sato,Masakazu Shimoda et al.
Koichi Tan-No et al.
The effects of various protease inhibitors on naloxone-precipitated withdrawal jumping were examined in morphine-dependent mice. The doses of morphine were subcutaneously given twice daily for 2 days (day 1, 30 mg/kg; day 2, 60 mg/kg). On d...
The amino-terminal region of hemokinin-1 regulates the induction of thermal hyperalgesia in rats [0.03%]
血激肽原酶-1的氨基末端调控区域调节大鼠热性疼痛过敏的诱导作用
N Sunakawa,R Naono,T Ikeda et al.
N Sunakawa et al.
It is known that intrathecal administration of substance P (SP) induces thermal hyperalgesia, whereas hemokinin-1 (HK-1), a member of the same tachykinin family as SP, hardly induces thermal hyperalgesia; however, the underlying mechanism r...