Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1 [0.03%]
神经降压素及其受体在胰腺癌中的高表达及SR 48692能阻断神经降压素所致人胰腺导管癌PANC-1细胞增生作用
Ji-Gang Wang,Ning-Ning Li,Hai-Na Li et al.
Ji-Gang Wang et al.
The presence of neurotensin and neurotensin receptors has been demonstrated in human pancreatic carcinomas using autoradiography and Northern blot analysis. In vitro studies have reported that the neurotensin antagonist SR 48692 could inhib...
Sarah-Jane Smillie,Susan D Brain
Sarah-Jane Smillie
Hypertension is still presently the number one "silent killer" in the Western World, and a major risk factor for the development of secondary diseases contributing to cardiovascular disease (CVD). However, despite a broad range of therapies...
Soon Lee,Brian Braden,Sang Soo Kang et al.
Soon Lee et al.
The synthesis and release of testosterone (T) depends both on circulating luteinizing hormone (LH) and on an array of testicular factors whose role remains incompletely understood. Corticotropin-releasing factor (CRF) had been reported in t...
Treatment with a melanocortin agonist improves abnormal lipid metabolism in streptozotocin-induced diabetic mice [0.03%]
用黑素皮质素受体激动剂治疗可改善链脲佐菌素诱导的糖尿病小鼠异常脂代谢
Arnold Leckstrom,Pei San Lew,Nicole J Poritsanos et al.
Arnold Leckstrom et al.
Impairments in leptin-melanocortin signaling are associated with insulin-deficient diabetes and leptin treatment has been shown to be effective in reversing hyperglycemia in animal models of type 1 diabetes. Therefore, we hypothesized that ...
Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased susceptibility to in vivo renal ischemia/reperfusion injury [0.03%]
缺垂体腺苷酸环化酶激活多肽(PACAP)小鼠对肾缺血再灌注损伤的敏感性增加
Peter Szakaly,Eszter Laszlo,Krisztina Kovacs et al.
Peter Szakaly et al.
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with well-known cytoprotective effects. We have reported earlier that PACAP decreases mortality and the degree of tubular atrophy in a rat model of renal ischemia/...
Extending pharmacological spectrum of opioids beyond analgesia: multifunctional aspects in different pathophysiological states [0.03%]
阿片类药物药理作用的扩展：在不同病理生理状态下的多效性方面超越镇痛作用
Dharmraj Singh Sauriyal,Amteshwar Singh Jaggi,Nirmal Singh
Dharmraj Singh Sauriyal
Opioids are well known to exert potent central analgesic actions. In recent years, the numerous studies have unfolded the critical role of opioids in the pathophysiology of various diseases as well as in biological phenomenon of therapeutic...
Vasopressin induces human mesangial cell growth via induction of vascular endothelial growth factor secretion [0.03%]
血管加压素通过诱导血管内皮生长因子的分泌来促进人系膜细胞增殖
Atsuo Tahara,Junko Tsukada,Yuichi Tomura et al.
Atsuo Tahara et al.
Vasoactive hormones, growth factors, and cytokines are important in promoting mesangial cell growth, a characteristic feature of many glomerular diseases. Vascular endothelial growth factor (VEGF) is an endothelial mitogen and promoter of v...
The localization of brain sites of anxiogenic-like effects of urocortin-2 [0.03%]
乌 cortin-2 作用的脑靶点的定位研究
A Skórzewska,A Bidziński,M Lehner et al.
A Skórzewska et al.
The influence of intracerebroventricullary-administered urocortin-2, a selective corticotropin-releasing factor receptor 2 (CRF(2)) agonist, on rat anxiety-like behaviour, the expression of c-Fos and CRF, and plasma corticosterone levels wa...
Electrophysiological evidence of biphasic action of carnosine on long-term potentiation in urethane-anesthetized rats [0.03%]
卡尼丁对尿烷麻醉大鼠长期增强的双向作用的电生理学证据
Cem Suer,Nazan Dolu,A Seda Artis et al.
Cem Suer et al.
Carnosine is a dipeptide synthesized by the carnosine synthetase from β-alanine and l-histidine. The well-known effects of carnosine may be related with mechanisms producing long-term potentiation which is one of the electrophysiological s...
Purkinje cells express Angiotensin II AT(2) receptors at different developmental stages [0.03%]
浦肯野细胞在不同发育阶段表达血管紧张素IIAT(2)受体
María E Arce,Susana I Sánchez,Francisco López Aguilera et al.
María E Arce et al.
Angiotensin II (Ang II) binds and activates two major receptors subtypes, namely AT(1) and AT(2). In the fetus, AT(2) receptors predominate in all tissues and decline shortly after birth, being restricted to a few organs including brain. In...