Enteroendocrine cell-derived peptide YY signalling is stimulated by pinolenic acid or Intralipid and involves coactivation of fatty acid receptors FFA1, FFA4 and GPR119 [0.03%]
棕榈油酸或Intralipid通过FFA1、FFA4和GPR119受体刺激肠内分泌细胞释放PYY肽激素信号
Iain R Tough,Runisha Moodaley,Helen M Cox
Iain R Tough
Long chain fatty acids are sensed by enteroendocrine L cells that express free-fatty acid receptors, including FFA1, FFA4 and the acylethanolamine receptor GPR119. Here we investigated the acute effects of single or multiple agonism at thes...
Adrenomedullin-mediated depressor response with visceral afferent-specific membrane depolarization in isolated nodose ganglion neurons from adult female rat [0.03%]
肾上腺素-medullin介导的降压反应和隔离成年雌性大鼠窦神经节神经元的内脏特异性膜去极化
Yan Feng,Ying Li,Hua Liu
Yan Feng
Adrenomedullin (ADM) is an endogenous and vasoactive neuropeptide that possesses potent central/peripheral regulations on blood pressure (BP) and sex-related vasodilation under physiological conditions. However, the role of ADM on barorefle...
Chao Wang,Jinxia Zhai,Xuemei Zhou et al.
Chao Wang et al.
Epilepsy is a common neurological condition characterized by abnormal neuronal activity, often leading to cellular damage and death. There is evidence to suggest that lipid imbalances resulting in cellular death play a key role in the devel...
Phosphorylated NPY1R regulates phenotypic transition of vascular smooth muscle cells, inflammatory response and macrophage infiltration to promote intracranial aneurysm progression [0.03%]
磷酸化NPY1R通过调节血管平滑肌表型转化、炎症反应和巨噬细胞浸润促进颅内动脉瘤进展
Jian He,Yonghong Duan,Yuanding Jiang et al.
Jian He et al.
Background: Rupture of intracranial aneurysm (IA) could give rise to spontaneous subarachnoid hemorrhage, leading to a high disability rate and even death. NPY1R expression was upregulated in aneurysm tissues of IA patien...
Physiologically relevant lactate accumulation from exercise or peripheral injection does not alter central or peripheral appetite signaling in mice [0.03%]
运动或外周注射引起的相关生理乳酸积累不会改变小鼠中枢和外周的摄食信号
Seth F McCarthy,Michael S Finch,Rebecca E K MacPherson et al.
Seth F McCarthy et al.
Lactate has been implicated in exercise-induced appetite suppression though little work has explored the mechanisms underpinning its role. Recent work suggests lactate accumulation via exercise and intracerebroventricular injection can alte...
GnRH protective effects against long-term potentiation impairment induced by AANAT-siRNA [0.03%]
GnRH对AANAT-siRNA诱导的长时程增强损伤的保护作用
Leila Karimi-Zandi,Tahereh Ghorbandaiepour,Maryam Zahmatkesh et al.
Leila Karimi-Zandi et al.
There is an interplay between the gonadotropin-releasing hormone (GnRH) and melatoninergic systems. The key enzyme of melatonin synthesis (arylalkylamine N-acetyltransferase, AANAT), and GnRH receptors are expressed in the hippocampus. Whil...
The protective effects of orexin B in neuropathic pain by suppressing inflammatory response [0.03%]
下丘脑泌素B通过抑制炎症反应保护神经病理性疼痛的作用
Zuqing Zhu,Gang Chen,Jiangtao He et al.
Zuqing Zhu et al.
Chronic pain induced by pathological insults to the sensorimotor system is a typical form of neuropathic pain (NP), and the underlying mechanism is complex. Currently, there are no successful therapeutic interventions for NP. Orexin B is a ...
Melittin protects against neural cell damage in rats following ischemic stroke [0.03%]
蜂毒肽通过减少缺血再灌注大鼠神经元损伤保护脑功能
Xiang Yao,Junlong Kang,Yufei Li et al.
Xiang Yao et al.
Objective: In this study, we explored the neuroprotective effect of melittin (MEL) after brain ischemia using a rat model. Methods: The...
Ninjinyoeito ameliorates anorexia and changes in peptide YY and ghrelin levels of cisplatin-treated mice [0.03%]
宁晋洋益多太通过改善顺铂诱导的小鼠厌食症从而改变肽YY和 ghrelin 的水平
Akinobu Hatae,Takuya Watanabe,Chise Taniguchi et al.
Akinobu Hatae et al.
We explored the effect of Ninjinyoeito (NYT) on cisplatin-induced anorexia, which reduces cancer patient survival. Both gastrointestinal motility and plasma concentrations of gastrointestinal peptides were assessed. Nine-week-old ICR female...
Upregulation of Xbp1 in NPY/AgRP neurons reverses diet-induced obesity and ameliorates leptin and insulin resistance [0.03%]
NPY/AgRP神经元中Xbp1的上调逆转了饮食引起的肥胖并改善了瘦素和胰岛素抵抗现象
Jason Ajwani,Eunsang Hwang,Bryan Portillo et al.
Jason Ajwani et al.
The molecular mechanisms underlying neuronal leptin and insulin resistance in obesity and diabetes are not fully understood. In this study, we show that induction of the unfolded protein response transcription factor, spliced X-box binding ...