Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence [0.03%]
三种合成肽的物理性质及体外保护活性评估：来源于GDNF前体和成熟序列
Kristen A Kelps,Jadwiga Turchan-Cholewo,Erin R Hascup et al.
Kristen A Kelps et al.
Recently, a small 11-amino acid amidated peptide, dopamine neuron stimulating peptide-11 (DNSP-11), was shown to exert neurotrophic-like actions on primary dopaminergic neurons and in parkinsonian rat models. This suggests smaller neurotrop...
Peptides: important tools for the treatment of central nervous system disorders [0.03%]
肽：中枢神经系统疾病治疗的重要工具
Luciana Malavolta,Francisco Romero Cabral
Luciana Malavolta
This review shows some classical applications of peptides and suggests there is great promise for the treatment of various central nervous system diseases. Actually, peptides are considered the new generation of biologically active tools be...
The role of nociceptin and dynorphin in chronic pain: implications of neuro-glial interaction [0.03%]
痛觉过敏素和dynorphin在慢性疼痛中的作用：神经-胶质相互作用的意义
Joanna Mika,Ilona Obara,Barbara Przewlocka
Joanna Mika
Nociceptin-opioid peptide (NOP) receptor, also known as opioid receptor like-1 (ORL1), was identified following the cloning of the kappa-opioid peptide (KOP) receptor, and the characterization of these receptors revealed high homology. The ...
Plasma brain-derived neurotrophic factor concentrations in children and adolescents [0.03%]
儿童和青少年脑源性神经营养因子浓度
L Iughetti,E Casarosa,B Predieri et al.
L Iughetti et al.
Background: Brain-derived neurotrophic factor (BDNF) is a mediator of neuronal plasticity influencing learning, memory and cognitive behavior. The aim of this study is to assess plasma BDNF variations according to puberta...
A putative morphological substrate of the catecholamine-influenced neuropeptide Y (NPY) release in the human hypothalamus [0.03%]
人纹状体中肾上腺素能影响的神经肽Y(NPY)释放的假定形态学底物
Laam Ko,Giorgio Rotoli,George Grignol et al.
Laam Ko et al.
Neuropeptide Y (NPY) is a 36 amino acid peptide, which among others, plays a pivotal role in stress response. Although previous studies confirmed that NPY release is increased by stress in several species, the exact mechanism of the stress-...
The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE) [0.03%]
外源性鸦片肽和DPPIV血清活性在呼吸暂停表现为突然发病事件的婴儿体内的变化
Jolanta Wasilewska,Edyta Sienkiewicz-Szłapka,Ewa Kuźbida et al.
Jolanta Wasilewska et al.
Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine β-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera...
Neuromedin U(2) receptor signaling mediates alteration of sleep-wake architecture in rats [0.03%]
神经调节肽U受体信号介导大鼠睡眠结构的变化
A Ahnaou,W H I M Drinkenburg
A Ahnaou
Growing evidence indicates that neuromedin U (NmU) neuropeptide system plays an integral role in mediating the stress response through the corticotrophin-releasing factor (CRF) pathways. Stress is often associated with alteration in sleep-w...
In vitro and ex vivo autoradiography of the NK-1 antagonist [³H]-LY686017 in Guinea pig brain [0.03%]
SPF小猪脑内和离体的[NK-1受体放射配基[³H]-LY686017的显影分布研究
Susan L Gackenheimer,Donald R Gehlert
Susan L Gackenheimer
NK-1 receptor antagonists have shown potential for the clinical treatment of chemotherapy-induced nausea and vomiting, depression and alcoholism. In a recent study, we disclosed the potential for the NK-1 antagonist, LY686017, to treat alco...
4-Methlycatechol prevents NGF/p75(NTR)-mediated apoptosis via NGF/TrkA system in pancreatic β cells [0.03%]
对二甲苯儿茶酚通过NGF/TrkA系统预防NGF/p75(NTR)介导的胰岛β细胞凋亡
Selda Gezginci-Oktayoglu,Sehnaz Bolkent
Selda Gezginci-Oktayoglu
In this study, it was aimed to investigate whether 4-methylcatechol (4-MC) could serve as an autocrine antiapoptotic agent by increasing nerve growth factor (NGF) in β cells of hyperglycemic rats. Rats were divided into four groups: the fi...
Oxytocin does not modify GH, ACTH, cortisol and prolactin responses to Ghrelin in normal men [0.03%]
催产素不会改变 ghrelin 对正常男性GH、ACTH、皮质醇和泌乳素的反应
Vittorio Coiro,Riccardo Volpi,Adriano Stella et al.
Vittorio Coiro et al.
Background: In order to test the possible effect of Oxytocin (OT) on Ghrelin-stimulated GH, PRL, ACTH and cortisol, ten healthy normal men were studied. T...