Glutathione in the blood and cerebrospinal fluid: a study in healthy male volunteers [0.03%]
血浆和脑脊液中的谷胱甘肽：健康男性志愿者研究
M Samuelsson,L Vainikka,K Ollinger
M Samuelsson
Glutathione (GSH) is an important regulator of intracellular redox homeostasis. In the brain, glutathione is considered a major antioxidant, which is also found at high concentrations in the extracellular environment. Altered GSH balance in...
Identification of positions in the human neuropeptide Y/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes [0.03%]
人神经肽Y/肽YY受体Y2的定位鉴定贡献了药理学差异之间的受体亚型
Helena Fällmar,Helena Åkerberg,Hugo Gutiérrez-de-Terán et al.
Helena Fällmar et al.
The members of the neuropeptide Y (NPY) family are key players in food-intake regulation. In humans this family consists of NPY, peptide YY (PYY) and pancreatic polypeptide (PP) which interact with distinct preference for the four receptors...
Activation of neuropeptide Y(2) receptors exerts an excitatory action on cardio-respiratory variables in anaesthetized rats [0.03%]
神经肽Y（2）受体激活对麻醉大鼠心肺变量的兴奋作用
Katarzyna Kaczyńska,Małgorzata Szereda-Przestaszewska
Katarzyna Kaczyńska
The respiratory effects of stimulation of NPYY(2) receptors were studied in spontaneously breathing rats that were either (i) neurally intact and subsequently bilaterally vagotomized in the neck, or (ii) neurally intact and subjected to sup...
Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons [0.03%]
促肾上腺皮质激素释放因子结合蛋白进入神经内分泌细胞和皮层神经元的调节分泌途径
Elías H Blanco,Juan Pablo Zúñiga,María Estela Andrés et al.
Elías H Blanco et al.
Corticotropin releasing factor binding protein (CRF-BP) is a 37kDa glycoprotein that binds CRF with high affinity. CRF-BP controls CRF levels within plasma during human pregnancy. It has also been shown that CRF-BP is expressed in various b...
Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney [0.03%]
肺神经肽对泌尿系统影响及其在肾脏保护作用的实验研究进展
Dora Reglodi,Peter Kiss,Gabriella Horvath et al.
Dora Reglodi et al.
Pituitary adenylate cyclase activating polypeptide (PACAP) is a widespread neuropeptide with diverse effects in the nervous system and peripheral organs. One of the most well-studied effects of PACAP is its cytoprotective action, against di...
Cyclosporine-A as a neuroprotective agent against stroke: its translation from laboratory research to clinical application [0.03%]
环孢素A作为防治卒中的神经保护剂：从实验研究到临床应用的转化
Mohamed M Osman,Dzenan Lulic,Loren Glover et al.
Mohamed M Osman et al.
Stoke remains a leading cause of death and disability with limited treatment options. Extensive research has been aimed at studying cell death events that accompany stroke and how to use these same cell death pathways as potential therapeut...
Differential roles of calcitonin family peptides in the dendrite formation and spinogenesis of the cerebral cortex in vitro [0.03%]
钙基因肽家族在体外大脑皮层树突形成和棘刺生成中发挥不同作用
Yuichi Harigai,Masaki Natsume,Fei Li et al.
Yuichi Harigai et al.
We examined roles of calcitonin family peptides in the initial stages of dendrite formation and the maturation of dendritic spines in the rat cerebral cortex in vitro. Embryonic day 18 cortical neurons were dissociated and cultured for 2-3d...
Multiple opioid receptors mediate the hypotensive response induced by central 5-HT(3) receptor stimulation [0.03%]
多个阿片受体介导由中枢5-HT(3)受体激活引起的低血压反应
J B Fregoneze,E F Oliveira,V F Ribeiro et al.
J B Fregoneze et al.
The aim of the present work was to investigate the role of brain μ, κ and δ opioid receptors in the central serotonergic mechanisms regulating blood pressure in rats. The data obtained show that: (1) pharmacological activation of central...
Neurokinin B activates the formation and bone resorption activity of rat osteoclasts [0.03%]
神经激肽B激活大鼠破骨细胞的形成和骨吸收活性
Takako Ichiki,Kayoko N Kuroishi,Kaori K Gunjigake et al.
Takako Ichiki et al.
Neurokinin B (NKB) is a neuropeptide in the tachykinin family that acts as a neurotransmitter and neuromodulator, primarily in the central nervous system. The distribution and role of NKB and its receptor, the neurokinin-3 receptor (NK-3R),...
Inhibitory CB1 and activating/desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin [0.03%]
大鼠皮肤中抑制CB1和激活/脱敏TRPV1的 cannabinoid 对CGRP释放的作用
Matthias A Engel,Iwona Izydorczyk,Sonja M Mueller-Tribbensee et al.
Matthias A Engel et al.
Cannabinoid-induced antinociception relies on activation of inhibitory cannabinoid receptors (CB1) in the peripheral and central nervous system. However, most cannabinoids at higher concentration also activate excitatory ionotropic transien...