Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways [0.03%]
中央神经肽Y输注和黑素皮质素受体4拮抗通过不同途径抑制促甲状腺功能
Elaine Preston,Gregory J Cooney,Donna Wilks et al.
Elaine Preston et al.
Weight loss inhibits thyrotropic function and reduces metabolic rate, thereby contributing to weight regain. Under negative energy balance there is an increase in the hypothalamic expression of both neuropeptide Y (NPY) and agouti related p...
Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry [0.03%]
液相色谱离子阱质谱法测定骨关节炎痛鼠模型中特异性神经肽的时效性变化规律
Catherine E Ferland,Floriane Pailleux,Pascal Vachon et al.
Catherine E Ferland et al.
Animal models are useful to evaluate pharmacological therapies to alleviate joint pain. The present study characterized central neuropeptides modulation in the monoiodoacetate (MIA) rat model. Animals receiving a single 3mg MIA injection we...
CART peptide stimulation of G protein-mediated signaling in differentiated PC12 cells: identification of PACAP 6-38 as a CART receptor antagonist [0.03%]
环状肽 CART 对分化的 PC12 细胞中 G 蛋白介导的信号传导的作用：PACAP 6-38 是一种 CART 受体拮抗剂
Yiming Lin,Randy A Hall,Michael J Kuhar
Yiming Lin
CART peptides are peptide neurotransmitters and hormones that are involved in many different physiological responses. While much is known about the peptides regarding their structure, processing and gene regulation, less is known about thei...
The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation [0.03%]
新生期母子分离影响幼年雌性大鼠摄食剥夺后孤束核内的弧状区NPY、POMC和CART表达水平
S B Yoo,V Ryu,E Y Park et al.
S B Yoo et al.
This study was conducted to examine the effect of neonatal maternal separation on the hypothalamic feeding peptides expression in young female offspring. Sprague-Dawley pups were separated from dam for 3h daily during PND 1-14 (MS), or left...
Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain [0.03%]
神经营养因子、氟西汀和阿米替林对大鼠脑基因表达的影响
John E McGeary,Volkan Gurel,Valerie S Knopik et al.
John E McGeary et al.
Evidence suggests that nerve growth factor (NGF) may have antidepressant properties but the pharmacological mechanisms remain unknown. Previously, we found that NGF improved performance in the forced swim test in Flinders Sensitive Line rat...
Regulation of the galanin system in the brainstem and hypothalamus by electroconvulsive stimulation in mice [0.03%]
电休克刺激对小鼠脑干和下丘脑中胰肽系统调节的影响
S H Christiansen
S H Christiansen
Induction of seizures by electroconvulsive stimulation (ECS) is amongst the most efficacious treatments for major depression. However, the working mechanism by which ECS exerts its antidepressant effects remains elusive. The galanin system ...
Immunomodulatory role of substance P in the wall lizard Hemidactylus flaviviridis: an in vitro study [0.03%]
壁花蜥(Hemidactylus flaviviridis)中P物质的免疫调节作用：体外研究
Sunil Kumar,Umesh Rai
Sunil Kumar
Present in vitro investigation for the first time in ectotherms demonstrated the immunomodulatory role of substance P in the wall lizard Hemidactylus flaviviridis. Substance P inhibited the percentage phagocytosis and phagocytic index of li...
Angiotensin III stimulates ERK1/2 mitogen-activated protein kinases and astrocyte growth in cultured rat astrocytes [0.03%]
血管紧张素Ⅲ刺激原代培养的大鼠星形胶质细胞的ERK1/2丝裂原活化蛋白激酶及增殖作用
Michelle A Clark,Hsieu Tran,Chinh Nguyen
Michelle A Clark
Angiotensin (Ang) III is a biologically active metabolite of Ang II with similar effects and receptor binding properties as Ang II. Most Ang III studies delineate physiological effects of the peptide but, the intracellular pathways leading ...
In adults with Prader-Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels [0.03%]
普拉德-威利综合征成人患者的饥饿素水平升高与过度摄食的关系比胰多肽和人胰肽水平更高有关
Louise Purtell,Lisa Sze,Georgina Loughnan et al.
Louise Purtell et al.
Objective: Prader-Willi syndrome (PWS) is a leading genetic cause of obesity, characterized by hyperphagia, endocrine and developmental disorders. It is suggested that the intense hyperphagia could stem, in part, from imp...
Vascular endothelial growth factor (VEGF) and its role in the central nervous system: a new element in the neurotrophic hypothesis of antidepressant drug action [0.03%]
血管内皮生长因子(VEGF)及其在中枢神经系统中的作用：一个新的神经营养假说的元素——关于抗抑郁药物的作用机制
Marta Maria Nowacka,Ewa Obuchowicz
Marta Maria Nowacka
Vascular endothelial growth factor (VEGF) is a well-known cellular mitogen, and a vascular growth factor and permeability regulator. It participates in physiological and pathological processes of angiogenesis and in the development of lymph...