Antioxidant PRDX3 gene therapy protects brain cells and prevents neurodegeneration in an animal model of Parkinson's disease [0.03%]
抗氧化基因PRDX3疗法可保护动物帕金森病模型中的脑细胞并防止神经退化
Sheila Adela Villa-Cedillo,Esrom Jared Acosta-Espinoza,Adolfo Soto-Domínguez et al.
Sheila Adela Villa-Cedillo et al.
Neurodegenerative diseases, including Parkinson's Disease (PD), are a significant global health challenge with no effective therapies to counteract neurodegeneration. Genetic and environmental factors lead to mitochondrial dysfunction and i...
The impact of endogenous N/OFQ on DPN: Insights into lower limb blood flow regulation in rats [0.03%]
内源性N/OFQ对糖尿病神经病变的影响：大鼠下肢血流调节的新启示
Yuan-Jing Qin,Po Zhang,Peng Zhang et al.
Yuan-Jing Qin et al.
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, often accompanied by impaired vascular endothelial function in the lower limbs. This dysfunction is characterized by a reduced vasodilatory response, leading to decr...
FMRFamide G protein-coupled receptors (GPCR) in the cuttlefish Sepiella japonica: Identification, characterization and expression profile [0.03%]
日本拟乌贼FMRFamide G蛋白偶联受体（GPCRs）的鉴定、特征分析及表达谱测定
Jian-Jun Xie,Ying Li,Jun-Hong Wu et al.
Jian-Jun Xie et al.
FMRFamide is a ubiquitous neuromodulator in the animal kingdom. Once FMRFamide or similar neuropeptides bind to their G protein-coupled receptors (GPCR), a series of signal transduction events are triggered, thereby mediating various physio...
NK1 receptor blockade disrupts microtumor growth and aggregation in a three-dimensional murine breast cancer model [0.03%]
NK1受体阻断破坏了三维乳腺癌小鼠模型中的微肿瘤生长和聚集现象
Silvia Gutierrez,M Danilo Boada
Silvia Gutierrez
Several data indicate that Substance P (SP) neurokinin type 1 receptor (NK1R) is at the center of the interaction between cancer cells and peripheral sensory neurons. Selecting the appropriate cancer cell line and its susceptibility to bein...
Protective effect of Apelin-13 on D-glutamic acid-induced excitotoxicity in SH-SY5Y cell line: An in-vitro study [0.03%]
阿普林-13对D-谷氨酸诱导的SH-SY5Y细胞系兴奋毒性的影响研究
Kadriye Yağmur Oruç,Gökhan Ağtürk,Aykut Oruç et al.
Kadriye Yağmur Oruç et al.
Excitotoxicity, resulting from excessive accumulation of glutamate in the extracellular space, leads to neuronal cell death. This study investigates the protective effects of Apelin-13 on D-Glutamic acid-induced excitotoxicity in SH-SY5Y hu...
Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem [0.03%]
人脑干中表达spexin和nesfatin-1的神经元的神经解剖学映射
Artur Pałasz,Klaudia Ozimirska,Aleksandra Suszka-Świtek et al.
Artur Pałasz et al.
Neuropeptides are involved in numerous brain activities being able to control a wide spectrum of physiological functions. In recent years, a number of novel pleiotropic regulatory peptides have been discovered in animal brain structures. Th...
Neuropeptides or their receptors in pathogenesis of lung diseases and therapeutic potentials [0.03%]
神经肽及其受体在肺部疾病发病机制中的作用及治疗潜力
Changgen Li,Na Zang,Enmei Liu
Changgen Li
There are complex interactions between the immune system and the nervous system in the lung. The nervous system perceives environmental stimuli and transmits these signals to immune cells via neurotransmitters, which is essential for effect...
Neuropeptide FF prevented histamine- or chloroquine-induced acute itch behavior through non-NPFF receptors mechanism in male mice [0.03%]
神经肽FF通过非NPFF受体机制预防组胺或氯喹所致的小鼠急性瘙痒行为
Honghai Tang,Ting Zhang,Jiamin Feng et al.
Honghai Tang et al.
The neuropeptide FF (NPFF) system regulates various physiological and pharmacological functions, particularly pain modulation. However, the modulatory effect of NPFF system on itch remains unclear. To investigate the modulatory effect and f...
Neuritogenesis and protective effects activated by Angiotensin 1-7 in astrocytes-neuron interaction [0.03%]
视神经元发生及血管紧张素1-7在胶质细胞与神经元互作中的保护作用机制研究
Gabriel Alberto de Carvalho Barbosa,Marina Prado Rubinho,Milton Kennedy Aquino-Júnior et al.
Gabriel Alberto de Carvalho Barbosa et al.
The renin angiotensin system (RAS) has been studied for its effects on various neurological disorders. The identification of functional receptors for Ang-(1-7) and Ang II peptides in astrocytes highlights the physiological modulation and th...
Paramita Basu,Bradley K Taylor
Paramita Basu
Pain and itch are regulated by a diverse array of neuropeptides and their receptors in superficial laminae of the spinal cord dorsal horn (DH). Neuropeptide Y (NPY) is normally expressed on DH neurons but not sensory neurons. By contrast, t...