Molecular mechanisms of GDNF/GFRA1/RET and PI3K/AKT/ERK signaling interplay in neuroprotection: Therapeutic strategies for treating neurological disorders [0.03%]
GDNF/GFRA1/RET和PI3K/AKT/ERK信号相互作用在神经保护中的分子机制：治疗神经系统疾病的治疗策略
Md Nasiruddin Khan,Divya Choudhary,Sidharth Mehan et al.
Md Nasiruddin Khan et al.
Neurological disorders, marked by progressive neuronal degeneration, impair essential cognitive functions like memory and motor coordination… This manuscript explores the significant roles of glial cell line-derived neurotrophic factor (GD...
Ginsenoside Rg1 improves autophagy dysfunction to ameliorate Alzheimer's disease via targeting FGR proto-oncogene [0.03%]
人参皂苷Rg1通过靶向FGR原癌基因改善自噬功能障碍以缓解阿尔茨海默病
Qiankun Quan,Xinxin Ma,JianJun Feng et al.
Qiankun Quan et al.
Alzheimer's disease (AD) is a neurodegeneration driven by beta-amyloid (Aβ) deposits in the brain involving autophagy dysfunction. Ginsenoside Rg1, a pharmacologically active compound found in ginseng, has possible therapeutic effects for ...
Bioactive peptides as multipotent molecules bespoke and designed for Alzheimer's disease [0.03%]
作为多功能分子特制和设计用于阿尔茨海默病的生物活性肽
Ana Mesias,Sandra Borges,Manuela Pintado et al.
Ana Mesias et al.
In an increasingly aging world where neurodegenerative diseases (NDs) are exponentially rising, research into more effective and innovative treatments seems paramount. Bioactive peptides (BPs) emerge as promising compounds with revolutionar...
BDNF-mediated depressor response by direct baroreceptor activation benefits for prevention and control of hypertension in high-latitude cold region [0.03%]
高纬度寒冷地区通过直接激活压力感受器而介导的由BDNF引起的压力下降有利于高血压的预防和控制
Yan Feng,Lei Yin,Ying Li
Yan Feng
Brian-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) signaling impacts on neuronal and cardiovascular physiology; however, its role in neurocontrol of circulation via baroreflex afferent pathway is largely unknown. Gene and pro...
Mechanistic role of proteins and peptides in Management of Neurodegenerative Disorders [0.03%]
蛋白质和肽在神经退行性障碍管理中的作用机制
Saumya Awasthi,Prafulla Chandra Tiwari,Srishti Awasthi et al.
Saumya Awasthi et al.
Proteins and peptides have emerged as significant contributors in the management of neurodegenerative disorders due to their diverse biological functions. These biomolecules influence various cellular processes, including cellular repair, i...
Modulation of temporoammonic-CA1 synapses by neuropeptide Y is through Y1 receptors in mice [0.03%]
神经肽Y通过小鼠Y1受体调节颞侧乳头体-CA1突触联系
Mariana A Cortes,Aundrea F Bartley,Qin Li et al.
Mariana A Cortes et al.
Reduced levels of neuropeptide Y (NPY), an abundant neuromodulator in the brain, are linked to multiple neuropsychiatric disorders, including post-traumatic stress disorder (PTSD). The CA1 region of hippocampus is important for anxiety regu...
Phoenixin-14 inhibits the formation of cerebral aneurysms in rats by downregulating the p38/NF-κB signaling pathway [0.03%]
凤凰肽14通过下调p38/NF-κB信号通路抑制大鼠脑动脉瘤形成
Qizheng Li,Lin Zeng,Songyang Peng et al.
Qizheng Li et al.
Cerebral aneurysms (CA) are a serious condition characterized by the bulging of a blood vessel in the brain, which can lead to rupture and life-threatening bleeding. The pathophysiology of CA involves complex processes, particularly inflamm...
The effects of corticotropin-releasing factor (CRF) and urocortins on the serotonin (hydroxytryptamine, 5HT) released from the raphe nuclei (RN) [0.03%]
促肾上腺皮质激素释放因子(CRF)和尿崩素对脑干缝核释放的血清素(羟色胺,5-HT)的影响
Aliz Kovács,Patrícia Tancsics,Miklós Palotai et al.
Aliz Kovács et al.
Corticotropin-releasing factor (CRF) and urocortins (UCN1, UCN2 and UCN3) belong to the same CRF family of neuropeptides. They regulate the neuroendocrine, autonomic and behavioral responses to stress via two CRF receptors (CRF1 and CRF2). ...
Qiao-Ping Wang,An-Qi Li,Bei Wang et al.
Qiao-Ping Wang et al.
Non-nutritive sweeteners (NNSs) are used to reduce caloric intake by replacing sugar with compounds that are sweet but contain little or no calories. In this study, we investigate how non-nutritive sweetener sucralose to promote acute food ...
Transcranial pulsed current stimulation alleviates neuronal pyroptosis and neurological dysfunction following traumatic brain injury via the orexin-A/NLRP3 pathway [0.03%]
经颅脉冲电流刺激通过下丘脑肽 Orexin-A/NLRP3 通路缓解创伤性脑损伤后的神经元焦亡和神经功能障碍
Peng Yao,Qianhui Zhou,Bingkai Ren et al.
Peng Yao et al.
Traumatic brain injury (TBI) is a life-threatening condition with high incidence and mortality rates. The current pharmacological interventions for TBI exhibit limited efficacy, underscoring the necessity to explore novel and effective ther...