Inhibition of neurokinin B promotes functional recovery in traumatic brain injury by increasing M2 microglia [0.03%]
神经激肽B抑制通过增加M2小胶质细胞促进创伤性脑损伤的功能恢复
Fangjie Luo,Xiaoyun Li,Zhanpeng Zhu
Fangjie Luo
Microglial polarization into pro-inflammatory M1 and anti-inflammatory M2 phenotypes is critical for regulating neuroinflammation and tissue repair following traumatic brain injury (TBI). The M1/M2 balance determines neurological outcomes, ...
Catestatin attenuates cerebral ischemia/reperfusion injury and suppresses endoplasmic reticulum stress [0.03%]
катестатин减轻脑缺血再灌注损伤和抑制内质网应激
Xiaodong Zhang,Jiaxin Fan,Shuyin Ma et al.
Xiaodong Zhang et al.
Ischemic stroke is one of the leading causes of death worldwide. Catestatin (CST), as a pleiotropic hormone, displays an anti-apoptotic effect, in addition to its known roles in cardiovascular regulation. However, the role of CST in ischemi...
Chromogranin B: A versatile neuroendocrine protein regulating physiological and metabolic functions [0.03%]
染色粒蛋白B：一种调节生理和代谢功能的神经内分泌蛋白质
Chandramouli Mukherjee,Palki Chauksey,Aamna Jain et al.
Chandramouli Mukherjee et al.
Chromogranin B (CHGB) is a key member of the granin family of acidic proteins, predominantly localized in the secretory granules of professional secretory cells, such as neurons and neuroendocrine cells. It plays a crucial role in the regul...
Interplay of neuropeptide Y and autophagy in Alzheimer's disease: Therapeutic perspectives and mechanistic insights [0.03%]
神经肽Y和自噬在阿尔茨海默病中的相互作用：治疗视角和机制洞察
Dhiraj Lanjewar,Raj Katariya,Vinita Kale et al.
Dhiraj Lanjewar et al.
Alzheimer's disease (AD) is a progressive, chronic, neurodegenerative disorder involving cognitive impairment, neuronal loss, autophagy dysregulation, and toxic protein aggregates build-up, including amyloid-β plaques and hyperphosphorylat...
Irisin alleviates anxiety and deficits in fear extinction in PTSD within SPS mouse model [0.03%]
Irisin通过SPS建模的小鼠PTSD缓解焦虑和灭痕缺陷作用机制研究
Xupei Xie,Yandi Ding,Qizhi Yan et al.
Xupei Xie et al.
Post-Traumatic Stress Disorder (PTSD), a prevalent psychological disorder, emerges subsequent to a grave traumatic incident or a succession of such events. Irisin is expressed in brain regions such as the hippocampus and prefrontal cortex a...
Neuropeptide Y as a multifaceted modulator of neuroplasticity, Neuroinflammation, and HPA axis dysregulation: Perceptions into treatment-resistant depression [0.03%]
神经肽Y作为神经可塑性、神经炎症和HPA轴失调的多面调节因子：对难治性抑郁症治疗的新认识
Priyanka Singanwad,Amol Tatode,Mohammad Qutub et al.
Priyanka Singanwad et al.
Treatment-resistant depression (TRD) is a severe neurobiological and clinical category in which common antidepressants do not induce an adequate response. Neuropeptide Y (NPY), a neuropeptide highly conserved through evolution, is known to ...
Tauopathies: Emerging discoveries on tau protein, with a special focus on Alzheimer's disease [0.03%]
tau蛋白病：Tau蛋白新兴研究发现及其在阿尔茨海默症中的作用
Aishwarya Hattiholi,Harsha Hegde,Suhas Kumar Shetty
Aishwarya Hattiholi
Tauopathies encompass a group of neurodegenerative disorders (NDDs) driven by the abnormal accumulation of mutated tau protein, leading to hyperphosphorylation, neuronal damage, and neuroinflammation. The protein plays essential roles in br...
Dynorphin B induces mitochondrial fragmentation in NSCLC through the PKD/DRP-1 signaling pathway [0.03%]
Dynorphin B通过PKD/DRP-1信号通路诱导NSCLC细胞线粒体分裂
Yunxiao Li,Bin Zhou,Yuenan Yang et al.
Yunxiao Li et al.
Mitochondrial fragmentation and impairment are essential targets for therapeutic approach for non-small cell lung cancer (NSCLC), given their significant contributions to the persistence and progression of malignant cells. Dynorphin B (Dyn ...
Rapamycin reveals neuropeptide Y as a regulator of senescence and inflammatory pathways in arthritis [0.03%]
雷帕霉素揭示神经肽Y作为调节关节炎衰老和炎症途径的因子
Susana Aideé González-Chávez,Eduardo Chaparro-Barrera,Mario Loya-Rivera et al.
Susana Aideé González-Chávez et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by immune dysregulation and joint destruction. Cellular senescence has been implicated in the progression of RA through the senescence-...
Neuroprotective effect of Ac-SDKP peptide in SH-SY5Y cells and rat model of Parkinson's disease against 6-OHDA-induced oxidative stress and ER stress [0.03%]
神经保护肽Ac-SDKP通过对抗氧化应激和内质网应激对帕金森病模型细胞及大鼠的保护作用研究
Maryam Kamarehei,Hamid Zahednasab
Maryam Kamarehei
Oxidative stress and endoplasmic reticulum (ER) stress are key contributors to the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD), for which no definitive cure currently exists. This study investigated the ne...