Salivary oxytocin responses in mothers and full-term newborns in early skin-to-skin contact for the first 2 hours after birth: Effects of synthetic oxytocin administration and epidural analgesia in labor [0.03%]
产后1小时内母亲和足月新生儿早期肌肤接触的催产素反应：分娩时使用人工合成催产素及硬膜外镇痛的影响
Aya Tomita,Kaori Yonezawa,Yuriko Usui et al.
Aya Tomita et al.
Background: Epidural analgesia with synthetic oxytocin reduces maternal oxytocin levels in the early postpartum period. However, whether maternal and neonatal endogenous oxytocin levels in the first 2 h after birth are af...
Ultrastructural characterization of neuropeptide Y synapses in the central inferior colliculus of the Fischer Brown Norway rat [0.03%]
FischerBrownNorway大鼠中央下丘神经肽Y突触的超微结构特征研究
Laila S Almassri,Joshua C Harris,Kristen M Crane et al.
Laila S Almassri et al.
Introduction: The central nucleus of the inferior colliculus (ICc) is the primary target for ascending auditory projections from the lower auditory brainstem nuclei and the main source of ascending projections to the audi...
Role of interplay between endocannabinoids and neuropeptides in pathogenesis and therapy of depressive and anxiety disorders [0.03%]
内源大麻素与神经肽在抑郁和焦虑障碍发病机制及治疗中的作用
Miłosz Gołyszny,Jonasz Dragon,Ewa Obuchowicz
Miłosz Gołyszny
A growing body of evidence suggests the existence of a neurochemical and functional interplay between endocannabinoids and neuropeptides, which are both relevant for the pathomechanism and effects of pharmacotherapy in depressive and anxiet...
Inhibitory modulation of gastrointestinal motility in mice by Tyr-c[D-Lys-Gly-p-F-Phe-Asp]-D-Pro-NH2, a novel cyclic hexapeptide with multifunctional opioid agonism [0.03%]
一种新型的环己肽通过多效性阿片受体激动作用抑制小鼠胃肠运动功能调节研究:Tyr-c[D-Lys-Gly-p-F-Phe-Asp]-D-Pro-NH2
Weifan Ding,Qinqin Zhang,Mengna Zhang et al.
Weifan Ding et al.
Opioid analgesics are critical for managing moderate-to-severe pain，yet are limited by adverse gastrointestinal (GI) effects, notably constipation. This necessitates developing novel opioid agonists with robust analgesia and reduced GI side ...
Kisspeptin-54 ameliorates chondrocyte senescence in osteoarthritis via SIRT3-mediated telomere protection and p53 acetylation inhibition [0.03%]
亲吻肽54通过SIRT3介导的端粒保护和p53乙酰化抑制改善骨关节炎软骨细胞衰老
Zhuobin Yang,Jimo Li,Wenfeng Jin et al.
Zhuobin Yang et al.
Background: Osteoarthritis (OA), characterized by chondrocyte senescence and oxidative stress, affects over 300 million people globally. Kisspeptin-54, a neuropeptide with pleiotropic protective effects, was investigated ...
Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseases [0.03%]
活性肽和蛋白质/寡肽对神经病理途径的调节：靶向神经退行性疾病中的氧化应激
Sushil Giri,Phool Chandra
Sushil Giri
Neurodegenerative disorders (NDDs) pose a growing global health burden, primarily due to their progressive nature and the limited efficacy of existing treatments. Bioactive peptides and proteins/polypeptides, particularly those derived from...
Nesfatin1 attenuates autism-like behavior via antioxidant, anti-inflammatory activities in a prenatal valproic acid-induced rat model of autism [0.03%]
奈斯法廷-1通过抗氧化及抗炎作用缓解孕期丙戊酸诱导的大鼠自闭症模型的自闭症样行为
Mitra Farbin,Razieh Hajisoltani,Tourandokht Baluchnejadmojarad et al.
Mitra Farbin et al.
Nesfatin1, a multifunctional peptide involved in energy homeostasis and neural regulation, has emerged as a promising candidate for modulating neurodevelopmental disorders. The anti-inflammatory, antioxidant, and neuroprotective properties ...
The role of salivary neurotensin and oxytocin in emotional responses to stress inoculation [0.03%]
应激免疫的情感反应中唾液神经紧张素和催产素的作用
Matthew Branney,Madison Propp,Dalton Jensen et al.
Matthew Branney et al.
Neuropeptides comprise a class of signaling molecules that exert direct effects on target tissues and modulatory influences across multiple physiological systems; however, their roles in mediating stress responses remains incompletely chara...
Therapeutic potential of small peptides in Alzheimer's disease: Advances in memory restoration and targeted delivery systems [0.03%]
小肽在阿尔茨海默病治疗中的潜力：记忆恢复和靶向递送系统方面的进展
Poonam Verma,Rubina Khatun,Kiran Anjum Jew et al.
Poonam Verma et al.
Despite extensive research into Alzheimer's disease (AD), few therapeutic strategies have successfully addressed its core pathology at the synaptic level. Small peptides represent a promising class of therapeutic agents capable of modulatin...
Substance P mitigates lipopolysaccharide induced cognitive impairment in rats in a dose dependent manner [0.03%]
缓激肽以剂量依赖性方式缓解脂多糖所致大鼠认知障碍
Prasada Chowdari Gurram,Suman Manandhar,Sairaj Satarker et al.
Prasada Chowdari Gurram et al.
Neuroinflammation contributes to cognitive decline in Alzheimer's disease (AD), and the neurokinin pathway has been implicated in the pathophysiology of AD. Although Substance P (SP), an endogenous ligand to the neurokinin 1 receptor (NK1R)...