Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice [0.03%]
运动调节APOE表达在雌性APOE3和APOE4靶向小鼠的大脑皮层中的表达
Verona E Mulgrave,Abdulrahman A Alsayegh,Aida Jaldi et al.
Verona E Mulgrave et al.
Apolipoprotein E (ApoE) is the main cholesterol carrier of the brain and the ε4 gene variant (APOE4) is the most prevalent genetic risk factor for Alzheimer's disease (AD), increasing risk up to 15-fold. Several studies indicate that APOE4...
Analgesic tolerance and cross-tolerance to the bifunctional opioid/neuropeptide FF receptors agonist EN-9 and μ-opioid receptor ligands at the supraspinal level in mice [0.03%]
小鼠脑室水平对双功能阿片/神经肽FF受体激动剂EN-9及μ-阿片受体配体产生镇痛耐受性和交叉耐受性研究
Zhenglan Han,Guofei Jin,Jiancai Tang et al.
Zhenglan Han et al.
The chimeric peptide EN-9 was reported as a κ-opioid/neuropeptide FF receptors bifunctional agonist that modulated chronic pain with no tolerance. Many lines of evidence have shown that the effect of the κ-opioid receptor is mediated by n...
Regional differences of tachykinin effects on smooth muscle and pacemaker potentials of the stomach, duodenum, ileum and colon of an emetic model, the house musk shrews [0.03%]
吐酸模型-家麝鼩胃，十二指肠，回肠和结肠平滑肌及起搏电位的速激肽效应的区域差异性研究
Julia Y H Liu,Yingyi Deng,Jessica C M Hui et al.
Julia Y H Liu et al.
Background and aims: The contractile effects of tachykinins on the gastrointestinal tract are well-known, but how they modulate slow-waves, particularly in species capable of emesis, remains largely unknown. We aimed to e...
Neurotensin modulation of lipopolysaccharide induced inflammation of gut-liver axis: Evaluation using neurotensin receptor agonist and antagonist [0.03%]
神经张力素受体激动剂和拮抗剂评价神经张力素对脂多糖诱导的胃肠轴炎症的调节作用
Gyan Babu,Banalata Mohanty
Gyan Babu
Lipopolysaccharide (LPS), a toxic component of the cell wall of Gram-negative bacteria, is a potent immune stressor. LPS-induced inflammation of the gut-liver axis is well demonstrated. Neurotensin (NTS), a tri-decapeptide present in the ga...
Effects of intracerebroventricular and intravenous administration of Kisspeptin-54 and Gonadotropin-releasing hormone agonist in rats with ovarian hyperstimulation [0.03%]
静脉及脑室注射Kisspeptin-54和促性腺激素释放激素类似物对卵巢刺激大鼠的影响
Cansu Bilister Egilmez,Ahmet Koyu,Burcu Azak Pazarlar et al.
Cansu Bilister Egilmez et al.
Purpose: We aim to determine the effect of local and systemic administration of kisspeptin-54 on ovarian hyperstimulation. Methods: Imm...
Expression of phoenixin-14 and nesfatin-1 in the hypothalamo-pituitary-gonadal axis in the phases of the estrous cycle [0.03%]
凤九肽和nesfatin-1在动情周期各阶段下丘脑-垂体-性腺轴的表达
Tuba Parlak Ak,Mine Yaman,Ali Bayrakdar et al.
Tuba Parlak Ak et al.
Phoenixin-14 (PNX-14) and nucleobindin 2 (NUCB2)/nesfatin-1 are regulatory neuropeptides expressed in the hypothalamus. These neuropeptides can be effective in hormonal regulation of the hypothalamo-pituitary-gonadal (HPG) axis and reproduc...
4-hydroxyisoleucine mediated IGF-1/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats [0.03%]
4-羟基异亮氨酸介导的IGF-1 / GLP-1信号激活可预防丙酸诱导的大鼠自闭症样行为表型和神经化学缺陷
Sonalika Bhalla,Sidharth Mehan
Sonalika Bhalla
Autism is a neuropsychiatric disorder characterized by a neurotransmitter imbalance that impairs neurodevelopment processes. Autism development is marked by communication difficulties, poor socio-emotional health, and cognitive impairment. ...
Melittin ameliorates motor function and prevents autophagy-induced cell death and astrogliosis in rat models of cerebellar ataxia induced by 3-acetylpyridine [0.03%]
蜂毒肽改善小脑萎缩型共济失调模型大鼠的运动功能并防止自噬介导的神经元死亡及星形胶质细胞活化的作用研究(3-乙酰基吡啶诱导)
Zahra Aghighi,Zeynab Ghorbani,Meysam Hassani Moghaddam et al.
Zahra Aghighi et al.
Background: Cerebellar ataxia (CA) is a form of ataxia that adversely affects the cerebellum. This study aims to investigate the therapeutic effects of melittin (MEL) on a 3-acetylpyridine-induced (3-AP) cerebellar ataxia...
HLDF-6 peptides exhibit neuroprotective effects in the experimental model of preclinical Parkinson's disease [0.03%]
HLDF-6多肽在帕金森病实验模型中的神经保护作用研究
Yurii A Zolotarev,Stanislav I Shram,Aleksandr K Dadayan et al.
Yurii A Zolotarev et al.
The mechanisms of the neuroprotective action of the hexapeptides HLDF-6 encoded by the amino acid sequence 41-46 of Human Leukemia Differentiation Factor and its homoserine derivative HLDF-6H were studied in an experimental 1-methyl-4-pheny...
Amylin regulates testosterone levels via steroidogenesis-related enzymes in the central nervous system of male mice [0.03%]
酰唀肽通过中枢神经系统中的类固醇生成相关酶调节小鼠的睾丸激素水平
Yujie Chen,Qiang Li,Xiaojing Li et al.
Yujie Chen et al.
Amylin is a peripheral satiation signal polypeptide co-secreted with insulin by pancreatic β-cells in response to nutrient ingestion. Amylin participates in the eating-inhibitory effect and regulates energy metabolism by acting on the cent...