Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain [0.03%]
阿片生长因子受体：成年小鼠大脑神经元中的解剖分布及受体共定位
Zainab Y Kareem,Patricia J McLaughlin,Rashmi Kumari
Zainab Y Kareem
The opioid growth factor (OGF) is an endogenous peptide that binds to the nuclear-associated receptor (OGFr), and plays a significant role in the proliferation of developing, renewing, and healing tissues. The receptor is widely expressed i...
Sex-dimorphic hindbrain lactate regulation of ventromedial hypothalamic nucleus glucoregulatory neuron 5'-AMP-activated protein kinase activity and transmitter marker protein expression [0.03%]
半脑乳酸调节ventromedial hypothalamic核糖核酸葡萄糖调节神经元5'-AMP活化蛋白激酶活性和发变剂标记蛋白质表达的两性差异性
Prabhat R Napit,Md Haider Ali,A S M Hasan Mahmood et al.
Prabhat R Napit et al.
Background: The oxidizable glycolytic end-product L-lactate is a gauge of nerve cell metabolic fuel stability that metabolic-sensory hindbrain A2 noradrenergic neurons impart to the brain glucose-regulatory network. Curre...
Interactions between the regulatory peptide 26RFa (QRFP) and insulin in the regulation of glucose homeostasis in two complementary models: The high fat 26RFa-deficient mice and the streptozotocin insulin-deficient mice [0.03%]
调节肽26RFa(QRFP)与胰岛素在两种互补模型葡萄糖稳态调节中的相互作用：高脂肪26RFa缺陷型小鼠和链脲佐菌素糖尿病小鼠
Marie-Anne Le Solliec,Arnaud Arabo,Saloua Takhlidjt et al.
Marie-Anne Le Solliec et al.
The regulatory peptide 26RFa (QRFP) is involved in the control of glucose homeostasis at the periphery by acting as an incretin, and in the brain by mediating the central antihyperglycemic effect of insulin, indicating the occurrence of a c...
The stress-induced antinociceptive responses to the persistent inflammatory pain involve the orexin receptors in the nucleus accumbens [0.03%]
应激引起的持续性炎症痛觉过敏反应与阿黑皮素原受体在伏隔核中的作用有关
Seyed Mohammadmisagh Moteshakereh,Mohammad Nikoohemmat,Danial Farmani et al.
Seyed Mohammadmisagh Moteshakereh et al.
Stress suppresses the sense of pain, a physiological phenomenon known as stress-induced analgesia (SIA). Brain orexin peptides regulate many physiological functions, including wakefulness and nociception. The contribution of the orexinergic...
Altered neurotransmission in stress-induced depressive disorders: The underlying role of the amygdala in depression [0.03%]
应激性抑郁障碍中神经递质传递的改变：杏仁体在抑郁症中的作用
Muhammad Asim,Huajie Wang,Abdul Waris
Muhammad Asim
Depression is the second leading cause of disability in the world population, for which currently available pharmacological therapies either have poor efficacy or have some adverse effects. Accumulating evidence from clinical and preclinica...
Search for lipidized PrRP analogs with strong anorexigenic effect: In vitro and in vivo studies [0.03%]
具有强烈厌食效果的脂肽化的PrRP类似物的筛选：体内外研究
Veronika Strnadová,Alena Karnošová,Miroslava Blechová et al.
Veronika Strnadová et al.
Prolactin-releasing peptide (PrRP) is an anorexigenic neuropeptide that attenuates food intake and increases energy expenditure. We designed three series of new lipidized PrRP31 analogs of different lengths of fatty acids attached at amino ...
Curcumin attenuates morphine dependence by modulating μ-opioid receptors and glial cell-activated neuroinflammation in rat [0.03%]
姜黄素通过调节大鼠的μ阿片受体及小胶质细胞激活的神经炎症来减轻吗啡依赖
Mohammad Abbas Sheikholeslami,Siavash Parvardeh,Shiva Ghafghazi et al.
Mohammad Abbas Sheikholeslami et al.
In recent years, the association between neuroinflammation and opioid dependence has attracted considerable attention. Curcumin, a component of the Curcuma longa, has been shown to act as a suppressor of glial cells and inflammatory cytokin...
Investigating the potential of GalR2 as a drug target for neuropathic pain [0.03%]
探讨GalR2作为神经性疼痛药物靶点的潜力
Kirsty Rich,Samrina Rehman,Jeff Jerman et al.
Kirsty Rich et al.
Neuropathic pain is a chronic and debilitating condition characterised by episodes of hyperalgesia and allodynia. It occurs following nerve damage from disease, inflammation or injury and currently impacts up to 17% of the UK population. Ex...
Organization of the galaninergic neuronal system in the brain of the gecko Hemidactylus frenatus [0.03%]
壁虎(Hemidactylus frenatus)脑中加兰林能神经系统的组织结构
Ananya Ganeyan,C B Ganesh
Ananya Ganeyan
Galanin (GAL) is a 29 amino acid peptide present in the central nervous system (CNS) as well as peripheral tissues in vertebrates. However, the brain distribution pattern of GAL is understudied in reptiles. The aim of this study was to dete...
The management and metabolic characterization: hyperthyroidism and hypothyroidism [0.03%]
管理及代谢特征：甲状腺功能亢进和减退
Yangyang Wang,YanPing Sun,Bingyou Yang et al.
Yangyang Wang et al.
Hyperthyroidism and hypothyroidism are common diseases resulting from thyroid dysfunction, and are simple to diagnose and treat. The traditional treatment for hypothyroidism is thyroid hormone replacement therapy. The traditional treatments...