FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer's disease [0.03%]
FGF-18通过海马神经营养作用改善阿尔茨海默病模型大鼠学习记忆障碍及神经病理改变
Arzuhan Cetindag Ciltas,Sebahattin Karabulut,Bilal Sahin et al.
Arzuhan Cetindag Ciltas et al.
Alzheimer's disease (AD) is a multifactorial pathology marked by amyloid beta (Aβ) accumulation, tau hyperphosphorylation, and progressive cognitive decline. Previous studies show that fibroblast growth factor 18 (FGF18) exerts a neuroprot...
Effects of voluntary, and forced exercises on neurotrophic factors and cognitive function in animal models of Parkinson's disease [0.03%]
自愿和强制运动对帕金森病动物模型神经生长因子及认知功能的影响
Forouzan Rafie,Mohammad Amin Rajizadeh,Mehdi Shahbazi et al.
Forouzan Rafie et al.
Background: Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly. Cognitive dysfunction represents a common and challenging non-motor symptom for people with Parkinson's disease. Th...
Neurobiochemical characteristics of arginine-rich peptides explain their potential therapeutic efficacy in neurodegenerative diseases [0.03%]
精氨酸丰富肽的神经生物化学特性解释了其在神经退行性疾病中的潜在治疗作用
Sedigheh Eskandari,Ameneh Rezayof,S Mohsen Asghari et al.
Sedigheh Eskandari et al.
Neurodegenerative diseases, including Alzheimer̕ s disease (AD), Parkinson̕ s disease (PD), Huntington̕ s disease (HD), and Amyotrophic Lateral Sclerosis (ALS) require special attention to find new potential treatment methods. This revie...
Hong-Mei Luo,Jia-Rong Ye,Fan-Qin Pu et al.
Hong-Mei Luo et al.
Visceral pain (VP) is caused by internal organ disease. VP is involved in nerve conduction and related signaling molecules, but its specific pathogenesis has not yet been fully elucidated. Currently, there are no effective methods for treat...
Restraint stress potentiates sensitivity to the antinociceptive effect of morphine through orexin receptors in the ventral tegmental area [0.03%]
伏隔核催产素受体介导限制性压力增强阿片类药物的镇痛作用
Sajad Mazaheri,Morteza Zendehdel,Abbas Haghparast
Sajad Mazaheri
Orexin signaling in the ventral tegmental area (VTA) plays a critical role in stress and addictive behaviors. On the other hand, exposure to stress potentiates behavioral sensitization to drugs of abuse such as morphine. This study aimed to...
Apelin receptor antagonist (ML221) treatment has a stimulatory effect on the testicular proliferation, antioxidants system and steroidogenesis in adult mice [0.03%]
阿普利林受体拮抗剂(ML221)治疗对成年小鼠睾丸增殖、抗氧化系统和类固醇生成的刺激效应
Milirani Das,Guruswami Gurusubramanian,Vikas Kumar Roy
Milirani Das
The expression of apelin and its receptor (APJ) has been shown in the hypothalamus-pituitary-testicular axis. It has also been suggested apelin and APJ are neuropeptide factors. The presence of apelin and APJ in the seminiferous tubules and...
Oxytocin as neuro-hormone and neuro-regulator exert neuroprotective properties: A mechanistic graphical review [0.03%]
催产素作为神经激素和神经调节剂发挥神经保护作用：机制图形综述
Roya Kamrani-Sharif,A Wallace Hayes,Mina Gholami et al.
Roya Kamrani-Sharif et al.
Background: Neurodegeneration is progressive cell loss in specific neuronal populations, often resulting in clinical consequences with significant medical, societal, and economic implications. Because of its antioxidant, ...
Protective effect of TNIP2 on the inflammatory response of microglia after spinal cord injury in rats [0.03%]
TNIP2对脊髓损伤后小胶质细胞炎症反应的抑制作用
Jiawei Fu,Chunshuai Wu,Guanhua Xu et al.
Jiawei Fu et al.
Background: Spinal cord injury (SCI) is a devastating disease that can lead to tissue loss and neurological dysfunction. TNIP2 is a negative regulator of NF-κB signaling due to its capacity to bind A20 and suppress infla...
Anandamide improves food intake and orexinergic neuronal activity in the chronic sleep deprivation induction model in rats by modulating the expression of the CB1 receptor in the lateral hypothalamus [0.03%]
阿南达胺通过调节外侧下丘脑CB1受体表达改善慢性睡眠剥夺模型大鼠进食及下丘脑催素能神经元活性
Rafie Belali,Seyyed Ali Mard,Seyed Esmaeil Khoshnam et al.
Rafie Belali et al.
Sleep deprivation alters orexinergic neuronal activity in the lateral hypothalamus (LH), which is the main regulator of sleep-wake, arousal, appetite, and energy regulation processes. Cannabinoid receptor (CBR) expression in this area is in...
Hippocampal pituitary adenylate cyclase-activating polypeptide mediates rapid antidepressant-like effects of Yueju pill [0.03%]
越鞠丸的快速抗抑郁作用与海马区环磷酸腺苷生成肽有关研究
Li Ren,Hailou Zhang,Weiwei Tao et al.
Li Ren et al.
Yueju pill, a classic Chinese Medicine formulated, was recently found to produce rapid antidepressant-like effects in a PKA-CREB signaling-dependent manner. In our study, we found that the Yueju pill induced a remarkable increase in PACAP. ...