CDNF overexpression prevents motor-cognitive dysfunction by intrastriatal CPP-based delivery system in a Parkinson's disease animal model [0.03%]
基于脑内给药的CPP-CDNF系统可防止帕金森病动物模型运动及认知功能障碍恶化
Sheila A Villa-Cedillo,Daniel Matta-Yee-Chig,Adolfo Soto-Domínguez et al.
Sheila A Villa-Cedillo et al.
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compact (SNpc), and no effective treatment has yet been established to prevent PD. Neurotrophic factors, such as cerebral dopamine ne...
Magda Malewska-Kasprzak,Katarzyna Jowik,Marta Tyszkiewicz-Nwafor
Magda Malewska-Kasprzak
Oxytocin (OXT) is a hypothalamic peptide that plays a number of roles in the body, being involved in labor and lactation, as well as cognitive-emotional processes and social behavior. In recent years, knowledge of the physiology of OXT has ...
Neonatal oxytocin treatment alters levels of precursor and mature BDNF forms and modifies the expression of neuronal markers in the male rat hippocampus [0.03%]
新生牛垂体后叶素治疗改变男性大鼠海马源性神经生长因子水平及神经元标志物表达模式
Stanislava Bukatova,Alexandra Reichova,Zuzana Bacova et al.
Stanislava Bukatova et al.
Neuropeptide oxytocin appears to be involved in the formation of hippocampal circuitry, underlying social memory and behaviour. Recent studies point to the role of oxytocin in regulating the levels of nerve growth factors that could influen...
Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug prediction using virtual screening [0.03%]
利用组学分析和虚拟筛选进行药物预测，剖析HSP90AB1等热休克蛋白对抗胶质母细胞瘤和ependymoma的生物学功能意义
Sudhanshu Sharma,Pravir Kumar
Sudhanshu Sharma
Heat shock proteins (HSPs) are the evolutionary family of proteins that are highly conserved and present widely in various organisms and play an array of important roles and cellular functions. Currently, very few or no studies are based on...
The regulatory effects of the apelin/APJ system on depression: A prospective therapeutic target [0.03%]
阿普林/APJ系统对抑郁症的调控作用及其作为治疗靶点的潜力
Yanjun Tian,Ruihao Wang,Lin Liu et al.
Yanjun Tian et al.
Depression is a debilitating neuropsychological disorder characterized by high incidence, high recurrence, high suicide, and high disability rates, which poses serious threats to human health and imposes heavy psychological and economic bur...
Mate calling alters expression of neuropeptide, cocaine- and amphetamine- regulated transcript (CART) in the brain of male frog Microhyla nilphamariensis [0.03%]
雄性尼林尖塘蛙求偶鸣叫改变脑内神经肽卡金胺相关转录物(Cart)的表达
Shobha Bhargava,Ketaki Shetye,Swapnil Shewale et al.
Shobha Bhargava et al.
Croaking is a unique component of reproductive behaviour in amphibians which plays a key role in intraspecies communication and mate evaluation. While gonadal hormones are known to induce croaking, central regulation of sound production is ...
Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission [0.03%]
生长期间咀嚼减少通过影响三叉神经节并调节Wnt信号途径和ARHGAP33分子传递而抑制认知功能
Eri Misawa-Omori,Hidemasa Okihara,Takuya Ogawa et al.
Eri Misawa-Omori et al.
Binding of brain-derived neurotrophic factor (BDNF) to its receptor tyrosine kinase B (TrkB) is essential for the development of the hippocampus, which regulates memory and learning. Decreased masticatory stimulation during growth reportedl...
An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review [0.03%]
阿尔茨海默病近期进展的包容性研究：全面综述
Sukanya Singh,Mitali Mahajan,Dhawal Kumar et al.
Sukanya Singh et al.
Alzheimer's disease (AD) has remained elusive in revealing its pathophysiology and mechanism of development. In this review paper, we attempt to highlight several theories that abound about the exact pathway of AD development. The number of...
Bee venom ameliorates oxidative stress and histopathological changes of hippocampus, liver and testis during status epileptics [0.03%]
蜂毒通过改善海马、肝脏和睾丸的氧化应激及组织病理学变化来缓解癫痫状态
Esraa K Aly,Hanan S Mahmoud,Dalal Hussien M Alkhalifah et al.
Esraa K Aly et al.
The unrelenting progression of neurodegenerative diseases has a negative impact on affected individuals, their families, and society. Recurrent epileptic seizures are the hallmark of epilepsy, and treating it effectively remains difficult. ...
Protective effects of Zishen Huoxue recipe against neuronal injury in the neurovascular unit of rats with vascular dementia by interfering with inflammatory cascade-induced pyroptosis [0.03%]
补肾活血方通过干扰炎症级联诱导的pyroptosis保护血管性痴呆模型大鼠神经血管单元中神经元损伤的作用及机制研究
Ting Yao,Le Xie,Yao Xie et al.
Ting Yao et al.
Objective: Chinese herbal formulas show considerable therapeutic benefits in dementia. This study specifically explored the protective action of Zishen Huoxue recipe on the neurovascular unit (NVU) of rats with vascular d...