The role of NPY signaling pathway in diagnosis, prognosis and treatment of stroke [0.03%]
NPY信号通路在卒中诊断、预后和治疗中的作用
Taotao Jiang,Ting Zheng,Rundong Li et al.
Taotao Jiang et al.
Neuropeptide Y (NPY), an extensively distributed neurotransmitter within the central nervous system (CNS), was initially detected and isolated from the brain of a pig in 1982. By binding to its G protein-coupled receptors, NPY regulates imm...
A comparative study on the effects of human serum albumin and α-melanocyte-stimulating hormone fusion proteins on the anti-neuroinflammatory in the central nervous system of adult mice [0.03%]
人血清白蛋白与黑素细胞刺激素融合蛋白对成年小鼠中枢神经系统抗神经炎症影响的对比研究
Yiyao Liu,Yang Li,Xueyan Wei et al.
Yiyao Liu et al.
The immunomodulatory effects of α-melanocyte stimulating hormone (α-MSH) in the central nervous system (CNS) have been investigated for forty years. The clinical applications of α-MSH are limited due to its short half-life. Our previous ...
Comparative Study
Neuropeptides. 2024 Apr:104:102410. DOI:10.1016/j.npep.2024.102410 2024
Cyclooxygenase-2 inhibition affects the ratio of GluN2A/GluN2B receptor subunits through interaction with mGluR5 in the mouse brain [0.03%]
环氧化酶-2通过与mGluR5相互作用影响小鼠大脑中GluN2A / GluN2B受体亚基的比例
Katarzyna Stachowicz,Patrycja Pańczyszyn-Trzewik,Paulina Misztak et al.
Katarzyna Stachowicz et al.
N-methyl-D-aspartic acid receptors (NMDARs) are the most studied receptors in mammalian brains. Their role in depression, cognition, schizophrenia, learning and memorization, Alzheimer's disease, and more is well documented. In the search f...
Immunohistochemical determination of the excitatory and inhibitory axonal endings contacting NUCB2/nesfatin-1 neurons [0.03%]
免疫组织化学法确定联系NUCB2/nesfatin-1神经元的兴奋性和抑制性轴突末梢
Aynura Aghayeva,Duygu Gok Yurtseven,Nursel Hasanoglu Akbulut et al.
Aynura Aghayeva et al.
Nesfatin-1 is an anorexigenic peptide suppressing food intake and is synthesized and secreted by neurons located in the hypothalamus. Our study was aimed to demonstrate the effect of excitatory and inhibitory neurotransmitters on NUCB2/nesf...
Effects of somatostatin, a somatostatin agonist, and an antagonist, on a putative migraine trigger pathway [0.03%]
生长抑素及其类似物和受体拮抗剂对一种假想的偏头痛发病途径的影响作用
Geoffrey A Lambert,Alessandro S Zagami
Geoffrey A Lambert
Objective: To determine whether somatostatin (SST) could be a cortico-brainstem neurotransmitter involved in producing the headache of migraine. Backgroun...
New fraternine analogues: Evaluation of the antiparkinsonian effect in the model of Parkinson's disease [0.03%]
新的雌激素类似物：在帕金森病模型中的抗帕金森病作用评价
Andréia Biolchi Mayer,Henrique de Oliveira Amaral,Danilo Gustavo R de Oliveira et al.
Andréia Biolchi Mayer et al.
Venom-derived peptides are important sources for the development of new therapeutic molecules, especially due to their broad pharmacological activity. Previously, our research group identified a novel natural peptide, named fraternine, with...
Effect of valproic acid combined with transplantation of olfactory ensheathing cells modified by neurotrophic 3 gene on nerve protection and repair after traumatic brain injury [0.03%]
联合使用谷氨酸酸和神经保护营养因子3基因修饰嗅鞘细胞移植对创伤性脑损伤后神经保护及修复的影响
Haiming Li,Zhijie Yin,Shuangzhu Yue et al.
Haiming Li et al.
Background: Traumatic brain injury (TBI) often leads to cognitive and neurological dysfunction. Valproic acid (VPA) has a neuroprotective effect in acute central nervous system diseases; the neurotrophin 3 gene (NT-3) can...
Cross talk about the role of Neuropeptide Y in CNS disorders and diseases [0.03%]
神经肽Y在中枢神经系统紊乱和疾病中的作用的对话讨论
Rajeshwari Bale,Gaurav Doshi
Rajeshwari Bale
A peptide composed of a 36 amino acid called Neuropeptide Y (NPY) is employed in a variety of physiological processes to manage and treat conditions affecting the endocrine, circulatory, respiratory, digestive, and neurological systems. NPY...
Neuroprotective effect of the PACAP-ADNP axis on SOD1G93A mutant motor neuron death induced by trophic factors deprivation [0.03%]
PACAP-ADNP轴对营养因子缺乏诱导的SOD1G93A突变型运动神经元死亡的神经保护作用
Benedetta Magrì,Agata Grazia D&#x;Amico,Grazia Maugeri et al.
Benedetta Magrì et al.
Amyotrophic lateral Sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of motor neurons in the central nervous system. Mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) account for approx...
Improvement of actin dynamics and cognitive impairment in diabetes through troxerutin-mediated downregulation of TRPM7/CaN/cofilin [0.03%]
地奥司明通过下调TRPM7/CaN/cofilin改善糖尿病认知障碍及肌动蛋白动态异常
Hongyan Li,Jie Li,Pin Wang et al.
Hongyan Li et al.
Diabetic cognitive impairment is a central nervous complication of diabetes mellitus. Its specific pathogenesis is unknown, and no effective treatment strategy is currently available. An imbalance in actin dynamics is an important mechanism...