Neurocircuitry underlying the actions of glucagon-like peptide 1 and peptide YY3-36 in the suppression of food, drug-seeking, and anxiogenesis [0.03%]
GLP-1和PYY3-36在抑制进食、药物渴求及抗焦虑的神经环路机制研究
Yasmina Dumiaty,Brett M Underwood,Jenny Phy-Lim et al.
Yasmina Dumiaty et al.
Obesity is a critical health condition worldwide that increases the risks of comorbid chronic diseases, but it can be managed with weight loss. However, conventional interventions relying on diet and exercise are inadequate for achieving an...
Important role of NPY-Y4R signalling in the dual control of feeding and physical activity [0.03%]
NPY-Y4R信号在饮食和体力活动的双重控制中扮演重要角色
Lei Zhang,Herbert Herzog
Lei Zhang
The control of feeding and physical activity is tightly linked and coordinated. However the underlying mechanisms are unclear. One of the major regulatory systems of feeding behaviour involves neuropeptide Y (NPY) signalling, with the signa...
Galectin-9 and Tim-3 are upregulated in response to microglial activation induced by the peptide Amyloid-β (25-35) [0.03%]
肽化合物Amyloid-β (25-35)激活小胶质细胞诱导糖链结合蛋白galectin-9和T细胞免疫球蛋白粘附分子Tim-3的上调表达
Eleazar Ramírez Hernández,Luis Fernando Hernández Zimbrón,Emmanuel Segura Pérez et al.
Eleazar Ramírez Hernández et al.
Galectins are a group of β-galactoside-binding lectins associated with regulating immunological response. In the brains of AD patients and 5xFAD (familial AD) mice, galectin-3 (Gal-3) was highly upregulated and found to be expressed in mic...
Baroreflex afferent function is a part of insights of Leptin-mediated blood pressure reduction and Leptin-resistance hypertension [0.03%]
巴压反射传入功能是瘦素介导的血压降低和瘦素抵抗性高血压的部分见解
Shi-Gang Ren,Dong-Mei Li,Hua Liu
Shi-Gang Ren
The aim of this study is to verify the impact of Leptin in blood pressure (BP) regulation and Leptin-resistance in metabolic/neurogenic hypertension through baroreflex afferents and dysregulation. Artery BP/heart rate (HR) were measured whi...
Illuminating the neuropeptide Y4 receptor and its ligand pancreatic polypeptide from a structural, functional, and therapeutic perspective [0.03%]
从结构、功能和治疗的角度阐明神经肽Y4受体及其配体胰多肽
Corinna Schüß,Victoria Behr,Annette G Beck-Sickinger
Corinna Schüß
The neuropeptide Y4 receptor (Y4R), a rhodopsin-like G protein-coupled receptor (GPCR) and the hormone pancreatic polypeptide (PP) are members of the neuropeptide Y family consisting of four receptors (Y1R, Y2R, Y4R, Y5R) and three highly h...
Peripheral administration of lipidized NPAF and NPFF analogs does not influence central food intake regulation but induces anxiety-like behavior [0.03%]
脂质化NPAF和NPFF类似物的外周给药不会影响中枢对食物摄入的调节，但会引起类似焦虑的行为
Veronika Strnadová,Alena Morgan,Magdalena Škrlová et al.
Veronika Strnadová et al.
RF-amide peptides influence multiple physiological processes, including the regulation of appetite, stress responses, behavior, and reproductive and endocrine functions. In this study, we examined the roles of neuropeptide FF receptors (NPF...
Sneha Kispotta,Debajyoti Das,Shakti Ketan Prusty
Sneha Kispotta
Parkinson's disease, often known as PD, is a more common age-related neurological disorder that affects a huge number of older adults worldwide. Parkinson's disease is predominantly a movement-related pathosis and is distinguished by the de...
Perioperative changes of serum orphanin in diabetic patients and its relationship with sympathetic nervous system [0.03%]
糖尿病患者围手术期血清孤独素的变化及其与交感神经系统的联系
Lin-Zhong Zhang,Meng-Li Xie,Jing Li et al.
Lin-Zhong Zhang et al.
The occurrence of cardiovascular events in diabetic patients during the perioperative period is related to the activation of sympathetic nerves. Basic research shows that serum nociceptin/orphanin FQ (N/OFQ) levels in diabetic neuropathy ra...
Localization of truncated TrkB and co-expression with full-length TrkB in the cerebral cortex of adult mice [0.03%]
成人小鼠大脑皮层中截断的TrkB定位及与全长TrkB的共同表达
Koji Ohira
Koji Ohira
Brain-derived neurotrophic factor (BDNF), one of the neurotrophins, and its specific receptor TrkB, are abundantly distributed in the central nervous system (CNS) and have a variety of biological effects, such as neural survival, neurite el...
Measurement of neuropeptide Y with molecularly imprinted polypyrrole on carbon fiber microelectrodes [0.03%]
碳纤维微电极上分子印迹聚吡咯对神经肽YY的检测
Luis López,Kelly Lozano,John Cruz et al.
Luis López et al.
The measurement of neuropeptides using small electrodes for high spatial resolution would provide us with localized information on the release of neuromolecules. The release of Neuropeptide Y (NPY) is related to different neurological disea...