Bee venom as a promising therapeutic strategy in central nervous system diseases [0.03%]
蜜蜂毒液作为中枢神经系统疾病有前景的治疗策略
Zeinab Vahidinia,Shirin Barati,Abolfazl Azami Tameh et al.
Zeinab Vahidinia et al.
Central nervous system (CNS) disorders are one of the leading health problems today, accounting for a large proportion of global morbidity and mortality. Most these disorders are characterized by high levels of oxidative stress and intense ...
The activity of cholinergic neurons in the basal forebrain interferes with anesthesia-arousal process of propofol [0.03%]
基底前脑胆碱能神经元的活动干扰异丙酚麻醉-觉醒过程
Cai-Hua Feng,Xiao-Nan Du,Zhi Wang et al.
Cai-Hua Feng et al.
Previous research has demonstrated that basal forebrain (BF) regulates arousal during propofol anesthesia. However, as the BF comprises cholinergic neurons alongside two other types of neurons, the specific role of cholinergic neurons has n...
MP-13, a novel chimeric peptide of morphiceptin and pepcan-9, produces potent antinociception with limited side effects [0.03%]
新型嵌合肽MP-13产生强大的镇痛作用且副作用有限
Chenxi Mei,Jing Zhang,Zhanyu Niu et al.
Chenxi Mei et al.
Pharmacological investigations have substantiated the potential of bifunctional opioid/cannabinoid agonists in delivering potent analgesia while minimizing adverse reactions. Peptide modulators of cannabinoid receptors, known as pepcans, ha...
Chronic unpredictable stress (CUS) reduced phoenixin expression, induced abnormal sperm and testis morphology in male rats [0.03%]
慢性不可预测压力(CUS)通过降低不死鸟肽表达诱导雄性大鼠精子和睾丸形态异常
Zahra Isnaini Mohamed,Mageswary Sivalingam,Ammu K Radhakrishnan et al.
Zahra Isnaini Mohamed et al.
Chronic stress caused by prolonged emotional pressure can lead to various physiological issues, including reproductive dysfunction. Although reproductive problems can also induce chronic stress, the impact of chronic stress-induced reproduc...
Effects of an herbal adaptogen feed-additive on feeding-related hypothalamic neuropeptides in chronic cyclic heat-stressed chickens [0.03%]
一种药用草本适应原饲料添加剂对慢性周期性热应激鸡摄食相关下丘脑神经肽的影响
Elizabeth S Greene,Maryam Afkhami Ardakani,Sami Dridi
Elizabeth S Greene
Heat stress (HS) is a global serious issue in the poultry industry with numerous adverse effects, including increased stress, depressed feed intake (FI), poor growth performance and higher mortality. Herbal adaptogens, plant extracts consid...
A Na+ channel receptor of FMRFamide in the cephalopod Sepiella japonica: Identification, characterisation, and expression profiling during different stages of gonadal development [0.03%]
日本枪乌贼FMRFamide的钠通道受体：鉴定、特征分析及其在不同生殖腺发育阶段的表达谱分析
Hui-Min Cao,Jun-Hong Wu,Shuang Li et al.
Hui-Min Cao et al.
FMRFamide, a member of the neuropeptide family, is involved in numerous physiological processes. FMRFamide-activated sodium channels (FaNaCs) are a family of non-voltage-gated, amiloride-sensitive, Na+-selective channels triggered by the ne...
The phenotypic changes of Schwann cells promote the functional repair of nerve injury [0.03%]
施万细胞的表型转化促进神经损伤的功能修复
Shufen Liao,Yan Chen,Yin Luo et al.
Shufen Liao et al.
Functional recovery after nerve injury is a significant challenge due to the complex nature of nerve injury repair and the non-regeneration of neurons. Schwann cells (SCs), play a crucial role in the nerve injury repair process because of t...
V-ATPase B2 promotes microglial phagocytosis of myelin debris by inactivating the MAPK signaling pathway [0.03%]
V型质子泵B2通过抑制MAPK信号通路促进少突胶质细胞髓鞘清除作用
Yao Li,Yuhan Dai,Lan Chu
Yao Li
Microglial phagocytosis of myelin debris is a crucial process for promoting myelin regeneration in conditions such as multiple sclerosis (MS). Vacuolar-ATPase B2 (V-ATPase B2) has been implicated in various cellular processes, but its role ...
Hira Rafi,Hamna Rafiq,Muhammad Farhan
Hira Rafi
Agmatine, a naturally occurring polyamine derived from arginine via arginine decarboxylase, has been shown to play multifaceted roles in the mammalian body, impacting a wide range of physiological and pathological processes. This comprehens...
Fat mass and obesity-associated protein regulates RNA methylation associated with spatial cognitive dysfunction after chronic cerebral hypoperfusion [0.03%]
慢性脑低灌注后肥胖相关蛋白调控与空间认知功能障碍相关的RNA甲基化
Yanqing Wang,Zimei Wu,Yuyang He et al.
Yanqing Wang et al.
RNA methylation can epigenetically regulate learning and memory. However, it is unclear whether RNA methylation plays a critical role in the pathophysiology of Vascular dementia (VD). Here, we report that expression of the fat mass and obes...