The restraint stress-induced antinociceptive effects decreased by antagonism of both orexin receptors within the CA1 region of the hippocampus [0.03%]
拮抗海马CA1区两种下丘脑分泌素受体可减弱禁足所致的镇痛效应
Elaheh Danesh,Shahin Hassanpour,Bita Vazir et al.
Elaheh Danesh et al.
Studies have indicated that stress-related symptoms can lead to hormonal and neural changes, affecting the pain threshold and nociceptive behaviors. The precise role of orexin receptors (OX1r and OX2r) in stress-induced analgesia (SIA) rema...
Trefoil factor 1 (TFF1) reduces cerebral edema and gastric mucosal injury by regulating the EGFR/Src/FAK pathway in an intracerebral hemorrhage rat model [0.03%]
脑出血大鼠模型中 trefoil 因子 1(TFF1)通过调节 EGFR/Src/FAK 信号通路降低脑水肿和胃黏膜损伤
Chao Huang,Likun Wang,Guofeng Wu
Chao Huang
The destruction of the blood-brain barrier and damage to the gastrointestinal mucosa after intracerebral hemorrhage (ICH) are important reasons for its high disability and mortality rates. However, the exact etiology is not yet clear. In ad...
Expression and localization of the neuropeptide Y-Y4 receptor in the chick spleen: mRNA upregulation by high ambient temperature [0.03%]
高环境温度上调鸡脾神经肽Y-Y4受体的表达和定位：mRNA水平研究
Haruka Nishimura,Mohamed Z Elhussiny,Yoshimitsu Ouchi et al.
Haruka Nishimura et al.
High ambient temperatures (HT) can increase diencephalic neuropeptide Y (NPY) expression, and central injection of NPY attenuates heat stress responses while inducing an antioxidative state in the chick spleen. However, there is a lack of k...
Bromelain decreases oxidative stress and Neuroinflammation and improves motor function in adult male rats with cerebellar Ataxia induced by 3-acetylpyridine [0.03%]
菠萝蛋白酶通过降低氧化应激和神经炎症改善3-乙酰吡啶诱导的小鼠小脑共济失调症状
Reza Bahar,Maryam Jahani Chegeni,Azin Tahvildari et al.
Reza Bahar et al.
Bromelain is a plant-based molecule with antioxidant, antithrombotic, anticancer, and anti-inflammatory properties. Bromelain has been shown to reduce the release of inflammatory cytokines. This study aimed to determine whether bromelain ca...
Biochemical characterization of Prokineticin 2 binding to Prokineticin receptor 1 in zebrafish [0.03%]
斑马鱼Prokineticin 2与Prokineticin受体1结合的生化特性分析
Roberta Lattanzi,Maria Rosaria Fullone,Alessio De Biase et al.
Roberta Lattanzi et al.
Prokineticin 2 (PK2) binds to prokineticin receptor 1 and prokineticin receptor 2 (PKR1 and PKR2, respectively), two G protein-coupled receptors (GPCRs) that can mediate multiple signalling pathways by promoting the elevation of intracellul...
Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease [0.03%]
活性肽类化合物在阿尔茨海默病和帕金森病中的保护作用及机制研究进展
Xuying Ding,Yutong Chen,Xiaojun Zhang et al.
Xuying Ding et al.
Neurodegenerative diseases are the main causes of death and morbidity among elderly people worldwide. From the pathological point of view, oxidative stress, neuroinflammation, mitochondrial damage and apoptosis are the causes of neuronal di...
Bezafibrate protects blood-brain barrier (BBB) integrity against traumatic brain injury mediated by AMPK [0.03%]
贝扎菲布通过AMPK介导保护创伤性脑损伤后的血脑屏障结构和功能
Xiubao Yang,Qingyong Chang,Yan Wang et al.
Xiubao Yang et al.
Bezafibrate (BEZ) has displayed a wide range of neuroprotective effects in different types of neurological diseases. However, its pharmacological function in traumatic brain injury (TBI) is still unknown. In the current study, a TBI model w...
Chemogenetic activation ofarcuate nucleus NPY and NPY/AgRP neurons increases feeding behaviour in mice [0.03%]
化学遗传激活小鼠下丘脑弧切迹核NPY和NPY/AgRP神经元可增加摄食行为
Neda Rafiei,Caitlin S Mitchell,Caitlin R Tedesco et al.
Neda Rafiei et al.
Neuropeptide Y (NPY) plays a crucial role in controlling energy homeostasis and feeding behaviour. The role of NPY neurons located in the arcuate nucleus of the hypothalamus (Arc) in responding to homeostatic signals has been the focus of m...
Acute sleep deprivation (ASD) and cardioprotection: Impact of ASD on oxytocin-mediated sympathetic nervous activation preceding myocardial infarction [0.03%]
急性睡眠剥夺（ASD）与心脏保护作用：ASD对心肌梗死前催产素介导的交感神经激活的影响
Marjan Aghajani,Mozhgan Aghajani,Ehsan Kazemi Moghaddam et al.
Marjan Aghajani et al.
Introduction: This study explored how acute sleep deprivation (ASD) before myocardial ischemia influences oxytocin release from paraventricular (PVN) neurons and its correlation with sympathetic nervous system (SNS) activ...
Liangxue Tongyu prescription attenuates neuroinflammation by increasing cholecystokinin octapeptide in acute intracerebral hemorrhage rats [0.03%]
凉血通瘀方通过增加胆囊收缩素八肽减轻急性脑出血大鼠神经炎症作用机制研究
Jianxiang Li,Yingying Sun,Wenzhe Qiu et al.
Jianxiang Li et al.
Inflammatory reactions after acute intracerebral hemorrhage (AICH) contribute significantly to a poor prognosis. Liangxue Tongyu Prescription (LTP) has been proven to be clinically effective in treating AICH. Numerous studies have shown tha...